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Open AccessArticle

Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism

1
Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei 100, Taiwan
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School of Medicine, Fu-Jen Catholic University, New Taipei City 100, Taiwan
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Department of Cardiology, Cardinal Tien Hospital, Taipei 100, Taiwan
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Department of Gerontological Health Care, National Taipei University of Nursing and Health Sciences, Taipei 100, Taiwan
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Department of Emergency and Critical Care Medicine, Cheng Hsin Rehabilitation Medical Center, Taipei 100, Taiwan
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Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 100, Taiwan
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Division of Traumatology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 100, Taiwan
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Department of Physiology and Biophysics, Graduate Institute of Physiology, National Defense Medical Center, Taipei 100, Taiwan
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Department of Pediatrics, School of Medicine, National Defense Medical Center, Tri-Service General Hospital, National Defense Medical Center, Songshan Branch, Taipei 100, Taiwan
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Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 100, Taiwan
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Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 100, Taiwan
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(11), 1906; https://doi.org/10.3390/polym11111906
Received: 30 September 2019 / Revised: 12 November 2019 / Accepted: 14 November 2019 / Published: 19 November 2019
(This article belongs to the Special Issue Chitin and Chitosan: Properties and Applications)
There have been numerous recent advances in wound care management. Nevertheless, the assessment of hemostatic dressing is essential to enable surgeons and other physicians and healthcare professionals to make the correct decisions regarding the disposition of severe hemorrhage. Here, we investigated the relative efficacies of chitosan-based and conventional gauze dressings in a rat model of femoral artery hemorrhage and in patients with surgical wounds. Dressing effectiveness was evaluated based on hemostatic profiles, biocompatibility, antimicrobial activity, and blood factor responses in coagulation. Relative to standard gauze dressing, the chitosan fiber (CF) dressing treatment significantly shortened the time to hemostasis in injured rats. Moreover, the CF dressing significantly prolonged partial thromboplastin time, enhanced blood absorption, and reduced antithrombin production without altering the prothrombin ratio. Unlike regular gauze bandages, the CF dressing demonstrated remarkable antibacterial activity. The results of this study indicate the effectiveness of chitosan as a hemostatic dressing and elucidate its underlying mechanism. It is possible that chitosan surgical dressings could serve as first-line intervention in hospital emergency care for uncontrolled hemorrhage. View Full-Text
Keywords: antithrombin; chitosan dressing; coagulation factor; hemorrhage; hemostasis antithrombin; chitosan dressing; coagulation factor; hemorrhage; hemostasis
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MDPI and ACS Style

Wang, Y.-W.; Liu, C.-C.; Cherng, J.-H.; Lin, C.-S.; Chang, S.-J.; Hong, Z.-J.; Liu, C.-C.; Chiu, Y.-K.; Hsu, S.-D.; Chang, H. Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism. Polymers 2019, 11, 1906.

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