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Open AccessCommunication

In-Vitro Hemocompatibility of Polyaniline Functionalized by Bioactive Molecules

1
Centre of Polymer Systems, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic
2
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague 6, Czech Republic
3
Department of Hematology, Tomas Bata Regional Hospital in Zlín, 762 75 Zlín, Czech Republic
4
Faculty of Humanities, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic
5
Faculty of Technology, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic
6
Jožef Stefan Institute, Jamova 39, Ljubljana 1000, Slovenia
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(11), 1861; https://doi.org/10.3390/polym11111861
Received: 6 September 2019 / Revised: 22 October 2019 / Accepted: 1 November 2019 / Published: 11 November 2019
(This article belongs to the Special Issue Polymer Biointerfaces)
Hemocompatibility is an essential prerequisite for the application of materials in the field of biomedicine and biosensing. In addition, mixed ionic and electronic conductivity of conducting polymers is an advantageous property for these applications. Heparin-like materials containing sulfate, sulfamic, and carboxylic groups may have an anticoagulation effect. Therefore, sodium dodecylbenzenesulfonate, 2-aminoethane-1-sulfonic acid and N-(2-acetamido)-2-aminoethanesulfonic acid were used for modification of the representative of conducting polymers, polyaniline, and the resulting products were studied in the context of interactions with human blood. The anticoagulation activity was then correlated to surface energy and conductivity of the materials. Results show that anticoagulation activity is highly affected by the presence of suitable functional groups originating from the used heparin-like substances, and by the properties of polyaniline polymer itself. View Full-Text
Keywords: polymer conductivity; conducting polymer; polyaniline; hemocompatibility polymer conductivity; conducting polymer; polyaniline; hemocompatibility
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MDPI and ACS Style

Skopalová, K.; Capáková, Z.; Bober, P.; Pelková, J.; Stejskal, J.; Kašpárková, V.; Lehocký, M.; Junkar, I.; Mozetič, M.; Humpolíček, P. In-Vitro Hemocompatibility of Polyaniline Functionalized by Bioactive Molecules. Polymers 2019, 11, 1861. https://doi.org/10.3390/polym11111861

AMA Style

Skopalová K, Capáková Z, Bober P, Pelková J, Stejskal J, Kašpárková V, Lehocký M, Junkar I, Mozetič M, Humpolíček P. In-Vitro Hemocompatibility of Polyaniline Functionalized by Bioactive Molecules. Polymers. 2019; 11(11):1861. https://doi.org/10.3390/polym11111861

Chicago/Turabian Style

Skopalová, Kateřina; Capáková, Zdenka; Bober, Patrycja; Pelková, Jana; Stejskal, Jaroslav; Kašpárková, Věra; Lehocký, Marián; Junkar, Ita; Mozetič, Miran; Humpolíček, Petr. 2019. "In-Vitro Hemocompatibility of Polyaniline Functionalized by Bioactive Molecules" Polymers 11, no. 11: 1861. https://doi.org/10.3390/polym11111861

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