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Open AccessArticle

Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer

1
Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
2
Advanced Membrane Materials Center, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
3
R&D Center for Membrane Technology, Chung Yuan Christian University, Taoyuan 32023, Taiwan
4
Department of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(10), 1592; https://doi.org/10.3390/polym11101592
Received: 4 September 2019 / Revised: 23 September 2019 / Accepted: 24 September 2019 / Published: 29 September 2019
(This article belongs to the Special Issue Functionally Responsive Polymeric Materials II)
To reduce the side effects of immune drugs and the sustainable release of immune drugs on local parts, we have designed an injectable thermal-sensitive hydrogel containing an imiquimod-loaded liposome system. In the extracellular environment of tumor tissues (pH 6.4), 50% of the drug was released from the carrier, which could be a result of the morphological changes of the liposomal microstructure in the acidic environment. According to the results in animals, the drug-containing liposomes combined with hydrogel can be effectively applied in breast cancer therapy to delay the growth of tumors as well as to dramatically reduce the death rate of mice. View Full-Text
Keywords: liposomes; immunotherapy; temperature-sensitive hydrogel; injectable liposomes; immunotherapy; temperature-sensitive hydrogel; injectable
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MDPI and ACS Style

Tsai, H.-C.; Chou, H.-Y.; Chuang, S.-H.; Lai, J.-Y.; Chen, Y.-S.; Wen, Y.-H.; Yu, L.-Y.; Lo, C.-L. Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer. Polymers 2019, 11, 1592.

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