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Open AccessArticle

3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels

1
School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China
2
Black Flame Biomedical Lt.D, Shanghai 201318, China
3
School of Mechatronics and Automation, Shanghai University, Shanghai 200444, China
4
Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(10), 1584; https://doi.org/10.3390/polym11101584
Received: 7 August 2019 / Revised: 13 September 2019 / Accepted: 25 September 2019 / Published: 27 September 2019
(This article belongs to the Special Issue Additive Manufacturing of Polymeric Materials)
Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility. HA can be Ultraviolet (UV)-crosslinked by modification with methacrylic anhydride (HA-MA) and crosslinked by modification with 3,3′-dithiobis(propionylhydrazide) (DTP) (HA-SH) via click reaction. In the study presented in this paper, a 3D-bioprinted, double-crosslinked, hyaluronic-acid-based hydrogel for wound dressing was proposed. The hydrogel was produced by mixing HA-MA and HA-SH at different weight ratios. The rheological test showed that the storage modulus (G’) of the HA-SH/HA-MA hydrogel increased with the increase in the HA-MA content. The hydrogel had a high swelling ratio and a high controlled degradation rate. The in vitro degradation test showed that the hydrogel at the HA-SH/HA-MA ratio of 9:1 (S9M1) degraded by 89.91% ± 2.26% at 11 days. The rheological performance, drug release profile and the cytocompatibility of HA-SH/HA-MA hydrogels with loaded Nafcillin, which is an antibacterial drug, were evaluated. The wound dressing function of this hydrogel was evaluated by Live/Dead staining and CCK-8 assays. The foregoing results imply that the proposed HA-SH/HA-MA hydrogel has promise in wound repair applications. View Full-Text
Keywords: 3D bioprinting; hyaluronic acid; double-crosslinked; biodegradable; wound dressing 3D bioprinting; hyaluronic acid; double-crosslinked; biodegradable; wound dressing
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MDPI and ACS Style

Si, H.; Xing, T.; Ding, Y.; Zhang, H.; Yin, R.; Zhang, W. 3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels. Polymers 2019, 11, 1584.

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