Next Article in Journal
Various Structural Types of Cyanide-Bridged FeIII–MnIII Bimetallic Coordination Polymers (CPs) and Polynuclear Clusters Based-on A New mer-Tricyanoiron(III)Building Block: Synthesis, Crystal Structures, and Magnetic Properties
Next Article in Special Issue
3D Printing of Polymeric Multi-Layer Micro-Perforated Panels for Tunable Wideband Sound Absorption
Previous Article in Journal
Selective Localization of Carbon Black in Bio-Based Poly (Lactic Acid)/Recycled High-Density Polyethylene Co-Continuous Blends to Design Electrical Conductive Composites with a Low Percolation Threshold
Previous Article in Special Issue
In Situ WAXD and SAXS during Tensile Deformation Of Moulded and Sintered Polyamide 12
Open AccessArticle

3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels

School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China
Black Flame Biomedical Lt.D, Shanghai 201318, China
School of Mechatronics and Automation, Shanghai University, Shanghai 200444, China
Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada
Authors to whom correspondence should be addressed.
Polymers 2019, 11(10), 1584;
Received: 7 August 2019 / Revised: 13 September 2019 / Accepted: 25 September 2019 / Published: 27 September 2019
(This article belongs to the Special Issue Additive Manufacturing of Polymeric Materials)
Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility. HA can be Ultraviolet (UV)-crosslinked by modification with methacrylic anhydride (HA-MA) and crosslinked by modification with 3,3′-dithiobis(propionylhydrazide) (DTP) (HA-SH) via click reaction. In the study presented in this paper, a 3D-bioprinted, double-crosslinked, hyaluronic-acid-based hydrogel for wound dressing was proposed. The hydrogel was produced by mixing HA-MA and HA-SH at different weight ratios. The rheological test showed that the storage modulus (G’) of the HA-SH/HA-MA hydrogel increased with the increase in the HA-MA content. The hydrogel had a high swelling ratio and a high controlled degradation rate. The in vitro degradation test showed that the hydrogel at the HA-SH/HA-MA ratio of 9:1 (S9M1) degraded by 89.91% ± 2.26% at 11 days. The rheological performance, drug release profile and the cytocompatibility of HA-SH/HA-MA hydrogels with loaded Nafcillin, which is an antibacterial drug, were evaluated. The wound dressing function of this hydrogel was evaluated by Live/Dead staining and CCK-8 assays. The foregoing results imply that the proposed HA-SH/HA-MA hydrogel has promise in wound repair applications. View Full-Text
Keywords: 3D bioprinting; hyaluronic acid; double-crosslinked; biodegradable; wound dressing 3D bioprinting; hyaluronic acid; double-crosslinked; biodegradable; wound dressing
Show Figures

Graphical abstract

MDPI and ACS Style

Si, H.; Xing, T.; Ding, Y.; Zhang, H.; Yin, R.; Zhang, W. 3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels. Polymers 2019, 11, 1584.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop