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Polymers 2018, 10(6), 607; https://doi.org/10.3390/polym10060607

Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives

1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania
2
Department of Pharmaceutical Biotechnologies and Drug Industry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania
3
Department of Plastic Surgery, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania
4
Department of Physical Chemistry of Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore GhicaVoda Alley, Iasi 700487, Romania
5
Institut de Chimie Organique et Analytique (ICOA), Univ Orleans, UMR CNRS 7311, F-45067 Orléans, France
6
Department of Morphofunctional Sciences, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, Romania
*
Author to whom correspondence should be addressed.
Received: 30 April 2018 / Revised: 27 May 2018 / Accepted: 29 May 2018 / Published: 2 June 2018
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Abstract

New membranes based on chitosan and chitosan-hyaluronic acid containing new arginine derivatives with thiazolidine-4-one scaffold have been prepared using the ionic cross-linking method. The presence of the arginine derivatives with thiazolidine-4-one scaffold into the polymer matrix was proved by Fourier-transform infrared spectroscopy (FT-IR). The scanning electron microscopy (SEM) revealed a micro-porous structure that is an important characteristic for the treatment of burns, favoring the exudate absorption, the rate of colonization, the cell structure, and the angiogenesis process. The developed polymeric membranes also showed good swelling degree, improved hydrophilicity, and biocompatibility in terms of surface free energy components, which supports their application for tissue regeneration. Moreover, the chitosan-arginine derivatives (CS-6h, CS-6i) and chitosan-hyaluronic acid-arginine derivative (CS-HA-6h) membranes showed good healing effects on the burn wound model induced to rats. For these membranes a complete reepithelialization was observed after 15 days of the experiment, which supports a faster healing process. View Full-Text
Keywords: chitosan; hyaluronic acid; arginine derivatives; wound dressing chitosan; hyaluronic acid; arginine derivatives; wound dressing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Iacob, A.-T.; Drăgan, M.; Ghețu, N.; Pieptu, D.; Vasile, C.; Buron, F.; Routier, S.; Giusca, S.E.; Caruntu, I.-D.; Profire, L. Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives. Polymers 2018, 10, 607.

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