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Polymers 2018, 10(5), 540;

Intrinsic Fluorescence of PAMAM Dendrimers—Quenching Studies

Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska St., 90-236 Lodz, Poland
Author to whom correspondence should be addressed.
Received: 5 April 2018 / Revised: 10 May 2018 / Accepted: 15 May 2018 / Published: 17 May 2018
(This article belongs to the Special Issue Polymer Characterization)
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Intrinsic, non-traditional fluorescence of polyamidoamine (PAMAM) dendrimers that do not possess classical fluorophores has been attracting considerable interest for the last decade. Many hypotheses regarding the source of the fluorescence have appeared, but some of them are still disputable. In order to shed new light on the nature of the phenomenon, we applied quenchers that are normally used to study intrinsic fluorescence of proteins (i.e., KI, CsCl, and acrylamide). KI and acrylamide efficiently quenched steady state fluorescence of PAMAM G2, PAMAM G3, and PAMAM G4 dendrimers. Stern-Volmer plots exhibited a downward curvature that has been elucidated by heterogenous emission. We assume that there are two distinct fluorescent moieties in the dendrimer structure that are characterized by different accessibility to the quenchers. View Full-Text
Keywords: PAMAM; intrinsic emission; autofluorescence; quenching PAMAM; intrinsic emission; autofluorescence; quenching

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Konopka, M.; Janaszewska, A.; Klajnert-Maculewicz, B. Intrinsic Fluorescence of PAMAM Dendrimers—Quenching Studies. Polymers 2018, 10, 540.

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