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Polymers 2018, 10(4), 415; https://doi.org/10.3390/polym10040415

Fabrication and In Vitro Characterization of Electrochemically Compacted Collagen/Sulfated Xylorhamnoglycuronan Matrix for Wound Healing Applications

1
ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, Innovation Campus, University of Wollongong, Wollongong, NSW 2522, Australia
2
Department of Dermatology, St Vincent’s Hospital Melbourne, Melbourne, VIC 3065, Australia
3
Department of Medicine (Dermatology), University of Melbourne, Melbourne, VIC 3010, Australia
4
Venus Shell Systems Pty Ltd., 220 Bolong Road, Bomaderry, NSW 2541, Australia
5
School of Medicine, SMAH, University of Wollongong, Wollongong, NSW 2500, Australia
*
Authors to whom correspondence should be addressed.
Received: 20 March 2018 / Revised: 4 April 2018 / Accepted: 5 April 2018 / Published: 9 April 2018
(This article belongs to the Special Issue Protein Biopolymer)
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Abstract

Skin autografts are in great demand due to injuries and disease, but there are challenges using live tissue sources, and synthetic tissue is still in its infancy. In this study, an electrocompaction method was applied to fabricate the densely packed and highly ordered collagen/sulfated xylorhamnoglycuronan (SXRGlu) scaffold which closely mimicked the major structure and components in natural skin tissue. The fabricated electrocompacted collagen/SXRGlu matrices (ECLCU) were characterized in terms of micromorphology, mechanical property, water uptake ability and degradability. The viability, proliferation and morphology of human dermal fibroblasts (HDFs) cells on the fabricated matrices were also evaluated. The results indicated that the electrocompaction process could promote HDFs proliferation and SXRGlu could improve the water uptake ability and matrices’ stability against collagenase degradation, and support fibroblast spreading on the ECLCU matrices. Therefore, all these results suggest that the electrocompacted collagen/SXRGlu scaffold is a potential candidate as a dermal substitute with enhanced biostability and biocompatibility. View Full-Text
Keywords: sulfated xylorhamnoglycuronan; electrocompaction; biomimicry; tissue regeneration; skin scaffold; fibroblasts sulfated xylorhamnoglycuronan; electrocompaction; biomimicry; tissue regeneration; skin scaffold; fibroblasts
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kang, L.; Liu, X.; Yue, Z.; Chen, Z.; Baker, C.; Winberg, P.C.; Wallace, G.G. Fabrication and In Vitro Characterization of Electrochemically Compacted Collagen/Sulfated Xylorhamnoglycuronan Matrix for Wound Healing Applications. Polymers 2018, 10, 415.

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