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Open AccessArticle

Silk Fibroin/Polyvinyl Pyrrolidone Interpenetrating Polymer Network Hydrogels

National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China
3Bs Research Group, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Barco, 4805-017 Guimaraes, Portugal
Author to whom correspondence should be addressed.
Polymers 2018, 10(2), 153;
Received: 25 December 2017 / Revised: 2 February 2018 / Accepted: 4 February 2018 / Published: 6 February 2018
(This article belongs to the Special Issue Protein Biopolymer)
Silk fibroin hydrogel is an ideal model as biomaterial matrix due to its excellent biocompatibility and used in the field of medical polymer materials. Nevertheless, native fibroin hydrogels show poor transparency and resilience. To settle these drawbacks, an interpenetrating network (IPN) of hydrogels are synthesized with changing ratios of silk fibroin/N-Vinyl-2-pyrrolidonemixtures that crosslink by H2O2 and horseradish peroxidase. Interpenetrating polymer network structure can shorten the gel time and the pure fibroin solution gel time for more than a week. This is mainly due to conformation from the random coil to the β-sheet structure changes of fibroin. Moreover, the light transmittance of IPN hydrogel can be as high as more than 97% and maintain a level of 90% within a week. The hydrogel, which mainly consists of random coil, the apertures inside can be up to 200 μm. Elastic modulus increases during the process of gelation. The gel has nearly 95% resilience under the compression of 70% eventually, which is much higher than native fibroin gel. The results suggest that the present IPN hydrogels have excellent mechanical properties and excellent transparency. View Full-Text
Keywords: silk fibroin; PVP; interpenetrating polymer network; hydrogel; protein biopolymer silk fibroin; PVP; interpenetrating polymer network; hydrogel; protein biopolymer
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MDPI and ACS Style

Kuang, D.; Wu, F.; Yin, Z.; Zhu, T.; Xing, T.; Kundu, S.C.; Lu, S. Silk Fibroin/Polyvinyl Pyrrolidone Interpenetrating Polymer Network Hydrogels. Polymers 2018, 10, 153.

AMA Style

Kuang D, Wu F, Yin Z, Zhu T, Xing T, Kundu SC, Lu S. Silk Fibroin/Polyvinyl Pyrrolidone Interpenetrating Polymer Network Hydrogels. Polymers. 2018; 10(2):153.

Chicago/Turabian Style

Kuang, Dajiang; Wu, Feng; Yin, Zhuping; Zhu, Tian; Xing, Tieling; Kundu, Subhas C.; Lu, Shenzhou. 2018. "Silk Fibroin/Polyvinyl Pyrrolidone Interpenetrating Polymer Network Hydrogels" Polymers 10, no. 2: 153.

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