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Polymers 2018, 10(4), 410; https://doi.org/10.3390/polym10040410

Development of Mucoadhesive Chitosan Derivatives for Use as Submucosal Injections

1
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, 1-1 Gakuenkibanadai-nishi, Miyazaki 889-2192, Japan
2
Division of Biomedical Engineering, Research Institute, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
*
Author to whom correspondence should be addressed.
Received: 2 February 2018 / Revised: 3 April 2018 / Accepted: 4 April 2018 / Published: 6 April 2018
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Abstract

Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been used for surgical treatment of early gastric cancer. These endoscopic techniques require proper submucosal injections beneath the tumor to provide a sufficiently high submucosal fluid cushion (SFC) to facilitate clean dissection and resection of the tumor. Until now, the submucosal injection materials developed for endoscopic techniques such as EMR and ESD of tumors have been composed of macromolecules, proteins, or polysaccharides. We have been investigating the use of chitosan, a product that is obtained by the alkaline deacetylation of chitin, the second-most abundant natural polysaccharide. Specifically, we have been studying a photocrosslinked chitosan hydrogel (PCH) and solubilized chitosan derivatives for use as novel submucosal injections for endoscopic techniques. Notably, chitosan derivatives with lactose moieties linked to the amino groups of its glucosamine units can specifically interact with acidic mucopolysaccharides and mucins in submucosa without the need for the incorporation of harmful photoreactive groups nor potentially mutagenic ultraviolet irradiation. View Full-Text
Keywords: chitosan derivatives; mucoadhesive; mucopolysaccharide; endoscopic submucosal dissection; endoscopic mucosal resection; submucosal injection chitosan derivatives; mucoadhesive; mucopolysaccharide; endoscopic submucosal dissection; endoscopic mucosal resection; submucosal injection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hattori, H.; Ishihara, M. Development of Mucoadhesive Chitosan Derivatives for Use as Submucosal Injections. Polymers 2018, 10, 410.

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