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Green Strategies for Molecularly Imprinted Polymer Development

LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal
Author to whom correspondence should be addressed.
Polymers 2018, 10(3), 306;
Received: 26 January 2018 / Revised: 1 March 2018 / Accepted: 6 March 2018 / Published: 12 March 2018
(This article belongs to the Special Issue Molecularly Imprinted Polymers)
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Molecular imprinting is a powerful technology to create artificial receptors within polymeric matrices. Although it was reported for the first time by Polyakov, eighty-four years ago, it remains, nowadays, a very challenging research area. Molecularly imprinted polymers (MIPs) have been successfully used in several applications where selective binding is a requirement, such as immunoassays, affinity separation, sensors, and catalysis. Conventional methods used on MIP production still use large amounts of organic solvents which, allied with stricter legislation on the use and release of chemicals to the environment and the presence of impurities on final materials, will boost, in our opinion, the use of new cleaner synthetic strategies, in particular, with the application of the principles of green chemistry and engineering. Supercritical carbon dioxide, microwave, ionic liquids, and ultrasound technology are some of the green strategies which have already been applied in MIP production. These strategies can improve MIP properties, such as controlled morphology, homogeneity of the binding sites, and the absence of organic solvents. This review intends to give examples reported in literature on green approaches to MIP development, from nano- to micron-scale applications. View Full-Text
Keywords: molecular imprinting; supercritical carbon dioxide; ionic liquids; deep eutectic solvents (DESs); ultrasound-assisted; microwave synthesis molecular imprinting; supercritical carbon dioxide; ionic liquids; deep eutectic solvents (DESs); ultrasound-assisted; microwave synthesis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Viveiros, R.; Rebocho, S.; Casimiro, T. Green Strategies for Molecularly Imprinted Polymer Development. Polymers 2018, 10, 306.

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