Next Article in Journal
Nature-Inspired Green Procedure for Improving Performance of Protein-Based Nanocomposites via Introduction of Nanofibrillated Cellulose-Stablized Graphene/Carbon Nanotubes Hybrid
Next Article in Special Issue
Humidity-Induced Phase Transitions of Surfactants Embedded in Latex Coatings Can Drastically Alter Their Water Barrier and Mechanical Properties
Previous Article in Journal
Thickening Supercritical CO2 with π-Stacked Co-Polymers: Molecular Insights into the Role of Intermolecular Interaction
Previous Article in Special Issue
Facile and Rapid Formation of Giant Vesicles from Glass Beads

Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles

Department of Applied Physics, Facultad de Ciencias, Campus Fuentenueva, School of Sciences, and MNAT Unit of Excellence, University of Granada, 18071 Granada, Spain
Author to whom correspondence should be addressed.
Polymers 2018, 10(3), 269;
Received: 5 February 2018 / Revised: 27 February 2018 / Accepted: 3 March 2018 / Published: 6 March 2018
(This article belongs to the Special Issue Selected Papers from "ECIS 2017")
In this work a combined, multifunctional platform, which was devised for the simultaneous application of magnetic hyperthermia and the delivery of the antitumor drug gemcitabine, is described and tested in vitro. The system consists of magnetite particles embedded in a polymer envelope, designed to make them biocompatible, thanks to the presence of poly (ethylene glycol) in the polymer shell. The commercial particles, after thorough cleaning, are provided with carboxyl terminal groups, so that at physiological pH they present negative surface charge. This was proved by electrophoresis, and makes it possible to electrostatically adsorb gemcitabine hydrochloride, which is the active drug of the resulting nanostructure. Both electrophoresis and infrared spectroscopy are used to confirm the adsorption of the drug. The gemcitabine-loaded particles are tested regarding their ability to release it while heating the surroundings by magnetic hyperthermia, in principle their chances as antitumor agents. The release, with first-order kinetics, is found to be faster when carried out in a thermostated bath at 43 °C than at 37 °C, as expected. But, the main result of this investigation is that while the particles retain their hyperthermia response, with reasonably high heating power, they release the drug faster and with zeroth-order kinetics when they are maintained at 43 °C under the action of the alternating magnetic field used for hyperthermia. View Full-Text
Keywords: biocompatible polymer; drug delivery; gemcitabine; magnetic hyperthermia; magnetic nanoparticles biocompatible polymer; drug delivery; gemcitabine; magnetic hyperthermia; magnetic nanoparticles
Show Figures

Graphical abstract

MDPI and ACS Style

Iglesias, G.R.; Reyes-Ortega, F.; Checa Fernandez, B.L.; Delgado, Á.V. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles. Polymers 2018, 10, 269.

AMA Style

Iglesias GR, Reyes-Ortega F, Checa Fernandez BL, Delgado ÁV. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles. Polymers. 2018; 10(3):269.

Chicago/Turabian Style

Iglesias, G. R., Felisa Reyes-Ortega, B. L. Checa Fernandez, and Ángel V. Delgado. 2018. "Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles" Polymers 10, no. 3: 269.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop