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Polymers 2018, 10(3), 265;

The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections

Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia
Author to whom correspondence should be addressed.
Received: 19 January 2018 / Revised: 27 February 2018 / Accepted: 3 March 2018 / Published: 5 March 2018
(This article belongs to the Special Issue Advances in Chitin/Chitosan Characterization and Applications)
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The most frequent diseases of the urinary bladder are bacterial infections and bladder cancers. For both diseases, very high recurrence rates are characteristic: 50–80% for bladder cancer and more than 50% for bladder infections, causing loss of millions of dollars per year for medical treatment and sick leave. Despite years of searching for better treatment, the prevalence of bladder infections and bladder cancer remains unchanged and is even increasing in recent years. Very encouraging results in treatment of both diseases recently culminated from studies combining biopolymer chitosan with immunotherapy, and chitosan with antibiotics for treatment of bladder cancer and cystitis, respectably. In both pathways of research, the discoveries involving chitosan reached a successful long-lasting cure. The property of chitosan that boosted the effectivity of illness-specific drugs is its ability to enhance the accessibility of these drugs to the very sources of both pathologies that individual treatments without chitosan failed to achieve. Chitosan can thus be recognised as a very promising co-player in treatment of bladder cancer and bacterial cystitis. View Full-Text
Keywords: chitosan; biological activity; medical applications chitosan; biological activity; medical applications

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Erman, A.; Veranič, P. The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections. Polymers 2018, 10, 265.

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