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Bioactive Sr(II)/Chitosan/Poly(ε-caprolactone) Scaffolds for Craniofacial Tissue Regeneration. In Vitro and In Vivo Behavior

Faculty of Chemistry, Autonomous University of San Luis Potosi, San Luis Potosi 6, Salvador Nava Martínez, 78210 San Luis, S.L.P., Mexico
Institute of Polymer Science and Technology, ICTP-CSIC, C/Juan de la Cierva 3, 28006 Madrid, Spain
CIBER, Carlos III Health Institute, C/Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain
Faculty of Higher Studies, National Autonomous University of Mexico, Av. Chalma s/n Col. La Pastora, Cuautepec Barrio Bajo. Delegación Gustavo A. Madero, Ciudad de México 07160, Mexico
Faculty of Medicine, University of Salamanca, C/Alfonso X el Sabio, s/n, 37007 Salamanca, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Polymers 2018, 10(3), 279;
Received: 31 January 2018 / Revised: 23 February 2018 / Accepted: 2 March 2018 / Published: 7 March 2018
(This article belongs to the Collection Polysaccharides)
PDF [22538 KB, uploaded 7 March 2018]


In craniofacial tissue regeneration, the current gold standard treatment is autologous bone grafting, however, it presents some disadvantages. Although new alternatives have emerged there is still an urgent demand of biodegradable scaffolds to act as extracellular matrix in the regeneration process. A potentially useful element in bone regeneration is strontium. It is known to promote stimulation of osteoblasts while inhibiting osteoclasts resorption, leading to neoformed bone. The present paper reports the preparation and characterization of strontium (Sr) containing hybrid scaffolds formed by a matrix of ionically cross-linked chitosan and microparticles of poly(ε-caprolactone) (PCL). These scaffolds of relatively facile fabrication were seeded with osteoblast-like cells (MG-63) and human bone marrow mesenchymal stem cells (hBMSCs) for application in craniofacial tissue regeneration. Membrane scaffolds were prepared using chitosan:PCL ratios of 1:2 and 1:1 and 5 wt % Sr salts. Characterization was performed addressing physico-chemical properties, swelling behavior, in vitro biological performance and in vivo biocompatibility. Overall, the composition, microstructure and swelling degree (≈245%) of scaffolds combine with the adequate dimensional stability, lack of toxicity, osteogenic activity in MG-63 cells and hBMSCs, along with the in vivo biocompatibility in rats allow considering this system as a promising biomaterial for the treatment of craniofacial tissue regeneration. View Full-Text
Keywords: chitosan; PCL; strontium; scaffolds; craniofacial engineering chitosan; PCL; strontium; scaffolds; craniofacial engineering

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rodríguez-Méndez, I.; Fernández-Gutiérrez, M.; Rodríguez-Navarrete, A.; Rosales-Ibáñez, R.; Benito-Garzón, L.; Vázquez-Lasa, B.; San Román, J. Bioactive Sr(II)/Chitosan/Poly(ε-caprolactone) Scaffolds for Craniofacial Tissue Regeneration. In Vitro and In Vivo Behavior. Polymers 2018, 10, 279.

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