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Polymers 2018, 10(3), 235;

Chitosan Based Self-Assembled Nanoparticles in Drug Delivery

Institute of Polymer Chemistry, Johannes Kepler University, Altenberger Strasse 69, 4040 Linz, Austria
Centro de Biomateriales, Universidad de La Habana, Ave. Universidad S/N entre G y Ronda, 10400 La Habana, Cuba
Facultad de Química, Universidad de La Habana, Zapata S/N entre G y Carlitos Aguirre, 10400 La Habana, Cuba
Author to whom correspondence should be addressed.
Received: 31 January 2018 / Revised: 20 February 2018 / Accepted: 23 February 2018 / Published: 26 February 2018
(This article belongs to the Special Issue Advances in Chitin/Chitosan Characterization and Applications)
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Chitosan is a cationic polysaccharide that is usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive, and non-toxic. These excellent biological properties make chitosan a good candidate for a platform in developing drug delivery systems having improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles are found to be appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many procedures for obtaining chitosan nanoparticles have been proposed. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembly is a current and appealing approach. The grafting agent can be a hydrophobic moiety forming micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches for preparing chitosan nanoparticles by self-assembly through both procedures, and illustrates the state of the art of their application in drug delivery. View Full-Text
Keywords: chitosan; self-assembled; polyelectrolyte complex; nanoparticle; drug delivery chitosan; self-assembled; polyelectrolyte complex; nanoparticle; drug delivery

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Quiñones, J.P.; Peniche, H.; Peniche, C. Chitosan Based Self-Assembled Nanoparticles in Drug Delivery. Polymers 2018, 10, 235.

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