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Polymers 2018, 10(11), 1195; https://doi.org/10.3390/polym10111195

A Polymer-Gel Eye-Phantom for 3D Fluorescent Imaging of Millimetre Radiation Beams

Delft University of Technology, Faculty of Applied Sciences, Department of Radiation Science and Technology, Section Radiation and Isotopes for Health, Mekelweg 15, 2629 JB Delft, The Netherlands
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Received: 30 September 2018 / Revised: 18 October 2018 / Accepted: 23 October 2018 / Published: 26 October 2018
(This article belongs to the Special Issue Fluorescent polymers for sensing and imaging)
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Abstract

We have filled a 24 mm diameter glass sphere with a transparent polymer-gel that is radio-fluorogenic, i.e., it becomes (permanently) fluorescent when irradiated, with an intensity proportional to the local dose deposited. The gel consists of >99.9% tertiary-butyl acrylate (TBA), pre-polymerized to ~15% conversion, and ~100 ppm maleimido-pyrene (MPy). Its dimensions and physical properties are close to those of the vitreous body of the human eye. We have irradiated the gel with a 3 mm diameter, 200 kVp X-ray beam with a dose rate of ~1 Gy/min. A three-dimensional (3D) (video) view of the beam within the gel has been constructed from tomographic images obtained by scanning the sample through a thin sheet of UV light. To minimize optical artefacts, the cell was immersed in a square tank containing a refractive-index-matching medium. The 20–80% penumbra of the beam was determined to be ~0.4 mm. This research was a preparatory investigation of the possibility of using this method to monitor the millimetre diameter proton pencil beams used in ocular radiotherapy. View Full-Text
Keywords: radiotherapy eye-phantom; radio-fluorogenic gel; X-ray beam imaging; 3D radiation imaging; polymer gel dosimetry radiotherapy eye-phantom; radio-fluorogenic gel; X-ray beam imaging; 3D radiation imaging; polymer gel dosimetry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Luthjens, L.H.; Yao, T.; Warman, J.M. A Polymer-Gel Eye-Phantom for 3D Fluorescent Imaging of Millimetre Radiation Beams. Polymers 2018, 10, 1195.

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