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Polymers 2018, 10(1), 31;

Polymer-Based Nanomaterials and Applications for Vaccines and Drugs

1,* and 2,3,*
Key Laboratory of Chemical Engineering Process and Technology for High-efficiency Conversion, College of Chemistry and Material Sciences, Heilongjiang University, Harbin 150080, China
Key Laboratory of Microbiology, School of Life Science, Heilongjiang University, Harbin 150080, China
School of Biological Science and Technology, University of Jinan, Jinan 250022, China
These authors contributed equally to this study.
Authors to whom correspondence should be addressed.
Received: 9 October 2017 / Revised: 19 December 2017 / Accepted: 21 December 2017 / Published: 2 January 2018
(This article belongs to the Special Issue Hydrophilic Polymers)
Full-Text   |   PDF [1946 KB, uploaded 2 January 2018]   |  


Nanotechnology plays a significant role in drug development. As carriers, polymeric nanoparticles can deliver vaccine antigens, proteins, and drugs to the desired site of action. Polymeric nanoparticles with lower cytotoxicity can protect the delivered antigens or drugs from degradation under unfavorable conditions via a mucosal administration route; further, the uptake of nanoparticles by antigen-presenting cells can increase and induce potent immune responses. Additionally, nanomaterials are widely used in vaccine delivery systems because nanomaterials can make the vaccine antigen long-acting. This review focuses on some biodegradable polymer materials such as natural polymeric nanomaterials, chemically synthesized polymer materials, and biosynthesized polymeric materials, and points out the advantages and the direction of research on degradable polymeric materials. The application and future perspectives of polymeric materials as delivery carriers and vaccine adjuvants in the field of drugs and vaccines are presented. With the increase of knowledge and fundamental understandings of polymer-based nanomaterials, means of integrating some other attractive properties, such as slow release, target delivery, and alternative administration methods and delivery pathways are feasible. Polymer-based nanomaterials have great potential for the development of novel vaccines and drug systems for certain needs, including single-dose and needle-free deliveries of vaccine antigens and drugs in the future. View Full-Text
Keywords: vaccines; drugs; polymer-based nanomaterials; nanoparticles; delivery carriers; vaccine adjuvants vaccines; drugs; polymer-based nanomaterials; nanoparticles; delivery carriers; vaccine adjuvants

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Han, J.; Zhao, D.; Li, D.; Wang, X.; Jin, Z.; Zhao, K. Polymer-Based Nanomaterials and Applications for Vaccines and Drugs. Polymers 2018, 10, 31.

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