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Polymers 2018, 10(2), 171; https://doi.org/10.3390/polym10020171

Hyperbranched Glycopolymers of 2-(α-d-Mannopyranose) Ethyl Methacrylate and N,N’-Methylenebisacrylamide: Synthesis, Characterization and Multivalent Recognitions with Concanavalin A

1
College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
2
College of Chemical Engineering and Materials, Handan University, Handan 056005, China
*
Authors to whom correspondence should be addressed.
Received: 29 January 2018 / Revised: 8 February 2018 / Accepted: 9 February 2018 / Published: 10 February 2018
(This article belongs to the Special Issue Hydrophilic Polymers)
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Abstract

A series of novel hyperbranched poly[2-(α-d-mannopyranosyloxy) ethyl methacrylate-co-N,N’-methylenebisacrylamide] (HPManEMA-co-MBA) are synthesized via a reversible addition fragmentation polymerization (RAFT). The dosage ratios of linear and branch units are tuned to obtain different degree of branching (DB) in hyperbranched glycopolymers. The DB values are calculated according to the content of nitrogen, which are facilely determined by elemental analysis. The lectin-binding properties of HPManEMA-co-MBA to concanavalin A (ConA) are examined using a turbidimetric assay. The influence of defined DB value and molecular weight of HPManEMA-co-MBA on the clustering rate is studied. Notably, HPManEMA-co-MBAs display a low cytotoxicity in the MTT assay, thus are potential candidates for biomedical applications. View Full-Text
Keywords: hyperbranched; glycopolymers; RAFT; concanavalin A; cluster glycoside effect hyperbranched; glycopolymers; RAFT; concanavalin A; cluster glycoside effect
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhang, Y.; Wang, B.; Zhang, Y.; Zheng, Y.; Wen, X.; Bai, L.; Wu, Y. Hyperbranched Glycopolymers of 2-(α-d-Mannopyranose) Ethyl Methacrylate and N,N’-Methylenebisacrylamide: Synthesis, Characterization and Multivalent Recognitions with Concanavalin A. Polymers 2018, 10, 171.

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