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Open AccessArticle

Halogen and Hydrogen Bonding in Multicomponent Crystals of Tetrabromo-1H-Benzotriazole

Laboratory of Nanostructured Fluorinated Materials (NFMLab), Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta”, Politecnico di Milano, via L. Mancinelli 7, I-20131 Milano, Italy
Author to whom correspondence should be addressed.
Academic Editor: Peter Politzer
Crystals 2017, 7(11), 332;
Received: 18 September 2017 / Revised: 18 October 2017 / Accepted: 26 October 2017 / Published: 31 October 2017
(This article belongs to the Special Issue Analysis of Halogen and Other σ-Hole Bonds in Crystals)
4,5,6,7-Tetrabromo-1H-benzotriazole (TBBT) is still considered a reference inhibitor of casein kinase II (CK2), a valuable target for anticancer therapy, even though the poor solubility in water of this active pharmaceutical ingredient (API) has prevented its implementation in therapy. We decided to explore the interactions preferentially formed by TBBT in crystalline solids in order to obtain information helpful for the development of new TBBT cocrystals possibly endowed with improved bioavailability. In this paper, we describe the synthesis and the structural characterization of the TBBT methanol solvate and of the TBBT salt with N,N,N’,N’-tetramethylethylenediamine. It is shown that TBBT can give rise to several competing interactions. This API is clearly a good halogen bond (XB) donor, with bromine atoms adjacent to the triazole ring possibly better donors than the two others. TBBT is also a good hydrogen bond (HB) donor, with the triazole hydrogen forming an HB with the acceptor or being transferred to it. Interestingly, one of the triazole nitrogens was proven to be able to work as a hydrogen bond acceptor. View Full-Text
Keywords: halogen bonding; hydrogen bonding; supramolecular chemistry; self-assembly; pharmaceutical cocrystals; solvates halogen bonding; hydrogen bonding; supramolecular chemistry; self-assembly; pharmaceutical cocrystals; solvates
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MDPI and ACS Style

Baldrighi, M.; Metrangolo, P.; Pilati, T.; Resnati, G.; Terraneo, G. Halogen and Hydrogen Bonding in Multicomponent Crystals of Tetrabromo-1H-Benzotriazole. Crystals 2017, 7, 332.

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