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Crystals 2015, 5(4), 491-500;

Synthesis, Crystal Structure and DFT Studies of 8-chloro-3-((3-chlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine

Department of Environmental Engineering, China Jiliang University, Hangzhou 310018, China
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
Author to whom correspondence should be addressed.
Academic Editor: Helmut Cölfen
Received: 19 August 2015 / Revised: 22 October 2015 / Accepted: 23 October 2015 / Published: 2 November 2015
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8-chloro-3-((3-chlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine was synthesized and recrystallized from EtOH. The compound was characterized by 1H NMR, 13C NMR, FTIR, MS, elemental analysis and X-ray diffraction. The compound was crystallized in the monoclinic space group P2(1)/c with a = 8.1992(5), b = 21.7731(12), c = 7.8454(6) Å, α = 90, β = 108.421(7), γ = 90°, V = 1328.81 (15)Å3, Z = 4 and R = 0.0351. Theoretical calculation of the title compound was carried out with B3LYP/6-31G. The full geometry optimization was carried out by using the 6-31G basis set. The frontier orbital energy and atomic net charges were discussed. The experimental results of the compound have been compared with theoretical results and it was found that the experimental data shows good agreement with the calculated values. View Full-Text
Keywords: 1,2,4-triazolo[4,3-a]pyridine; hydrazine; synthesis; crystal structure; theoretical calculation 1,2,4-triazolo[4,3-a]pyridine; hydrazine; synthesis; crystal structure; theoretical calculation

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Mu, J.-X.; Yang, M.-Y.; Sun, Z.-H.; Tan, C.-X.; Weng, J.-Q.; Wu, H.-K.; Liu, X.-H. Synthesis, Crystal Structure and DFT Studies of 8-chloro-3-((3-chlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine. Crystals 2015, 5, 491-500.

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