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Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation

Symeres, Kadijk 3, 9747 AT Groningen, The Netherlands
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Academic Editors: Xiouras Christos, René Steendam and Joop H. ter Horst
Crystals 2021, 11(10), 1225; https://doi.org/10.3390/cryst11101225
Received: 13 September 2021 / Revised: 1 October 2021 / Accepted: 5 October 2021 / Published: 12 October 2021
(This article belongs to the Special Issue Advances in Chiral Crystallization, Resolution and Deracemization)
The resolution of 2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide (phencyphos) was achieved by dissolution of anhydrous racemic phencyphos, a racemic compound, accompanied by simultaneous secondary nucleation of the dissolved racemate on to enantiopure seeds of phencyphos hydrate, a conglomerate. The seeds were placed in separate compartments and the pure enantiomers could be conveniently collected from these compartments after the dissolution of the anhydrous racemate. View Full-Text
Keywords: resolution; phencyphos; pseudo-polymorph; conglomerate; racemic compound resolution; phencyphos; pseudo-polymorph; conglomerate; racemic compound
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MDPI and ACS Style

Leeman, M.; Kellogg, R.M. Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation. Crystals 2021, 11, 1225. https://doi.org/10.3390/cryst11101225

AMA Style

Leeman M, Kellogg RM. Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation. Crystals. 2021; 11(10):1225. https://doi.org/10.3390/cryst11101225

Chicago/Turabian Style

Leeman, Michel, and Richard M. Kellogg. 2021. "Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation" Crystals 11, no. 10: 1225. https://doi.org/10.3390/cryst11101225

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