Cocrystal Formation through Solid-State Reaction between Ibuprofen and Nicotinamide Revealed Using THz and IR Spectroscopy with Multivariate Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Methods
2.2.1. Storage of Tablets
2.2.2. Fourier-Transform Infrared Spectroscopy (FT-IR) Measurements
2.2.3. Terahertz Spectroscopy Measurements
2.2.4. Multivariate Analysis
3. Results and Discussion
3.1. FT-IR and THz Spectra
3.2. FT-IR Spectra and MCR-ALS Analysis
3.3. THz Spectra and MCR-ALS Analysis
3.4. Contributions of Thermal Energy
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Sample Number | 0% RH | 30% RH | 75% RH |
---|---|---|---|
1 | 0 | 0 | 0 |
2 | 24 | 6 | 6 |
3 | 48 | 12 | 12 |
4 | 96 | 24 | 18 |
5 | 168 | 36 | 30 |
6 | 216 | 48 | 42 |
7 | 264 | 60 | 54 |
8 | 336 | 84 | 66 |
9 | 384 | 156 | 90 |
10 | 432 | 204 | 114 |
11 | 504 | 252 | 186 |
12 | 552 | 324 | 234 |
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Ishihara, S.; Hattori, Y.; Otsuka, M.; Sasaki, T. Cocrystal Formation through Solid-State Reaction between Ibuprofen and Nicotinamide Revealed Using THz and IR Spectroscopy with Multivariate Analysis. Crystals 2020, 10, 760. https://doi.org/10.3390/cryst10090760
Ishihara S, Hattori Y, Otsuka M, Sasaki T. Cocrystal Formation through Solid-State Reaction between Ibuprofen and Nicotinamide Revealed Using THz and IR Spectroscopy with Multivariate Analysis. Crystals. 2020; 10(9):760. https://doi.org/10.3390/cryst10090760
Chicago/Turabian StyleIshihara, Sae, Yusuke Hattori, Makoto Otsuka, and Tetsuo Sasaki. 2020. "Cocrystal Formation through Solid-State Reaction between Ibuprofen and Nicotinamide Revealed Using THz and IR Spectroscopy with Multivariate Analysis" Crystals 10, no. 9: 760. https://doi.org/10.3390/cryst10090760