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Open AccessArticle

Influence of Chemical Modifications of Polyhydroxyalkanoate-Derived Fatty Acids on Their Antimicrobial Properties

1
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland
2
Medical University of Warsaw, Department of Pharmaceutical Microbiology, 3 Oczki Str. 02-007 Warsaw, Poland
3
Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland
*
Author to whom correspondence should be addressed.
Catalysts 2019, 9(6), 510; https://doi.org/10.3390/catal9060510
Received: 15 May 2019 / Revised: 29 May 2019 / Accepted: 30 May 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Environmental Biocatalysis: From Remediation to Waste Valorization)
Sugar esters are bioactive compounds derived from renewable resources. They consist of a sugar moiety with attached non-polar part – usually a fatty acid. These compounds find uses in cosmetic, food and pharmaceutical industries as surfactants due to their physicochemical and antimicrobial activities. In this study we have produced fatty acids for sugar ester synthesis from bacterially derived polyesters, namely polyhydroxyalkanoates (PHAs). We have developed methodology to decorate PHA monomers with a fluorinated moiety. With aid of biocatalysis a series of glucose esters was created with unmodified and modified PHA monomers. All synthesised compounds showed moderate antimicrobial activity. View Full-Text
Keywords: polyhydroxyalkanoate; (R)-3-hydroxyacids; biocatalysis; sugar esters; antimicrobial polyhydroxyalkanoate; (R)-3-hydroxyacids; biocatalysis; sugar esters; antimicrobial
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MDPI and ACS Style

Snoch, W.; Stępień, K.; Prajsnar, J.; Staroń, J.; Szaleniec, M.; Guzik, M. Influence of Chemical Modifications of Polyhydroxyalkanoate-Derived Fatty Acids on Their Antimicrobial Properties. Catalysts 2019, 9, 510. https://doi.org/10.3390/catal9060510

AMA Style

Snoch W, Stępień K, Prajsnar J, Staroń J, Szaleniec M, Guzik M. Influence of Chemical Modifications of Polyhydroxyalkanoate-Derived Fatty Acids on Their Antimicrobial Properties. Catalysts. 2019; 9(6):510. https://doi.org/10.3390/catal9060510

Chicago/Turabian Style

Snoch, Wojciech; Stępień, Karolina; Prajsnar, Justyna; Staroń, Jakub; Szaleniec, Maciej; Guzik, Maciej. 2019. "Influence of Chemical Modifications of Polyhydroxyalkanoate-Derived Fatty Acids on Their Antimicrobial Properties" Catalysts 9, no. 6: 510. https://doi.org/10.3390/catal9060510

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