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Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners

Department of Chemistry, College of Pharmacy, Army Medical University, Shapingba, Chongqing 400038, China
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road,Wuhan 430070, China
Authors to whom correspondence should be addressed.
Catalysts 2018, 8(1), 23;
Received: 27 December 2017 / Revised: 10 January 2018 / Accepted: 10 January 2018 / Published: 14 January 2018
(This article belongs to the Special Issue Catalyzed Mizoroki–Heck Reaction or C–H activation)


The Mizoroki-Heck reaction represents one of the most convenient methods for carbon-carbon double bond formation in the synthesis of small organic molecules, natural products, pharmaceuticals, agrochemicals, and functional materials. Fluorine-containing organic compounds have found wide applications in the research areas of materials and life sciences over the past several decades. The incorporation of fluorine-containing segments into the target molecules by the Mizoroki-Heck reactions is highly attractive, as these reactions efficiently construct carbon-carbon double bonds bearing fluorinated functional groups by simple procedures. This review summarizes the palladium-catalyzed Mizoroki-Heck reactions using various fluorine-containing reagents as the cross-coupling partners. The first part of the review describes the Pd-catalyzed Mizoroki-Heck reactions of aryl halides or pseudo-halides with the fluorinated alkenes, and the second part discusses the Pd-catalyzed Mizoroki-Heck reactions of the fluorinated halides or pseudo-halides with alkenes. Variants of the Pd-catalyzed Mizoroki-Heck reactions with fluorine-containing reagents are also briefly depicted. This work supplies an overview, as well as a guide, to both younger and more established researchers in order to attract more attention and contributions in the realm of Mizoroki-Heck reactions with fluorine-containing participants. View Full-Text
Keywords: Mizoroki-Heck reaction; Pd-catalyzed; fluorine; cross-coupling; alkenes; halides Mizoroki-Heck reaction; Pd-catalyzed; fluorine; cross-coupling; alkenes; halides

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yang, J.; Zhao, H.-W.; He, J.; Zhang, C.-P. Pd-Catalyzed Mizoroki-Heck Reactions Using Fluorine-Containing Agents as the Cross-Coupling Partners. Catalysts 2018, 8, 23.

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