Next Article in Journal
Thermal Activation of CuBTC MOF for CO Oxidation: The Effect of Activation Atmosphere
Previous Article in Journal
Environmental Benign Synthesis of Lithium Silicates and Mg-Al Layered Double Hydroxide from Vermiculite Mineral for CO2 Capture
Previous Article in Special Issue
Dehydrogenation of Isobutane with Carbon Dioxide over SBA-15-Supported Vanadium Oxide Catalysts
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:

Recyclable Polymer-Supported Terpyridine–Palladium Complex for the Tandem Aminocarbonylation of Aryl Iodides to Primary Amides in Water Using NaN3 as Ammonia Equivalent

Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan
Author to whom correspondence should be addressed.
Catalysts 2017, 7(4), 107;
Original submission received: 17 March 2017 / Revised: 3 April 2017 / Accepted: 5 April 2017 / Published: 7 April 2017
(This article belongs to the Special Issue Organometallic Catalysis for Organic Synthesis)


Primary aromatic amides are valuable compounds, which are generally prepared via Beckmann rearrangement of oximes and the hydration of nitriles in organic solvents. We investigated the environmentally friendly catalytic aminocarbonylation in water. Thus, a novel heterogeneous transition-metal catalyst, a polymer-supported terpyridine–palladium(II) complex, was prepared and found to promote azidocarbonylation of aryl iodides with NaN3 and to reduce the generated benzoyl azides in water under CO gas to yield primary aryl amides with high to excellent yield in a one-pot reaction. The catalyst was recovered and reused several times with no loss of catalytic activity.

Graphical Abstract

1. Introduction

Primary amides are valuable compounds that are present in several natural products, are important structural motifs in pharmacologically active molecules [1], and are useful in engineering materials such as conductive polymers [2,3]. Although general procedures have been established for their preparation [4,5,6,7,8], e.g., the Beckmann rearrangement of oximes and the hydration of nitriles, there is continuing demand for the development of catalytic, new, improved, effective, and environmentally friendly methodologies for the synthesis of primary amides. Recently, we developed the aminocarbonylation of aryl iodides to form primary amides in water using MeONH2 and a polymer-supported terpyridine–palladium(II) complex as an environmentally friendly synthesis; however, the reported reaction did not yield a high conversion efficiency [9].
Conversely, palladium-catalyzed carbonylation reactions of aromatic halides in the presence of several nucleophiles have undergone rapid development since the pioneering work of Heck and co-workers in 1974 [10]. With regard to the Heck carbonylation reaction, aminocarbonylation reactions have also been developed as an alternative to the preparation of secondary or tertiary amides, as described in [11]. In 2010, Beller and co-workers developed the palladium-catalyzed synthesis of primary amides using carbon monoxide and ammonia [12,13]. This reaction used gaseous ammonia and Pd(OAc)2/dppf or Pd(OAc)2/nBuP(1-Adamantyl)2 as the catalytic system. The toxicity of gaseous ammonia is the same as that of carbon monoxide at a threshold limit values of 50 ppm. Therefore, hexamethyldisilazane [14], formamide [15], titanium-nitrogen complexes, ammonium carbamate [16], and methoxyamine [17] have been researched as effective ammonia equivalents for the palladium-catalyzed aminocarbonylation reaction in an organic solvent.
From the viewpoint of green chemistry, three principal drawbacks of the reported protocol exist despite consideration of the environmental impact and cost of the reported reaction: (1) the expensive palladium catalyst needs to be disposed of after being used a few times; (2) the products might become contaminated; (3) the organic solvent is both expensive and toxic.
On the contrary, we recently developed an amphiphilic polystyrene–poly(ethylene glycol) (PS–PEG) resin-supported terpyridine–palladium complex as a phosphine-free catalyst and found it to be effective for metal-catalyzed reactions in water under heterogeneous and aerobic conditions with high recyclability [18,19,20,21]. As an extension of that study, we investigated the catalytic use of the PS–PEG–terpyridine–palladium(II) complex for the azidocarbonylation of aryl halides using sodium azide as an ammonium equivalent and subsequently performed reduction with polymethylhydrosiloxane (PMHS) to produce primary amides in water. Although sodium azide is highly toxic, it is ease to handle because it is not gaseous, and it has advantage that it can be handled stably in water. There is only one reported example of a Pd/Xantphos catalyzed azidocarbonylation reaction in tetrahydrofuran (THF)-producing benzoyl azide products, and this was not performed with the aim of synthesizing primary amines [22].
In this report, complexes of the type [(R3P)2Pd(Ph)N3] have been reported not to undergo CO insertion into a Pd–Ph bond under identical reaction conditions due to conversion to [(R3P)2Pd(Ph)NCO] + N2 [23]; these problems could be overcome using Xantphos, which has wide bite angles [24]. We herein report the results of this investigation and demonstrate that the complex effectively catalyzes the aminocarbonylation of various aryl iodides with carbon monoxide in water using a terpyridine ligand having a wide bite angle, N1–Pd–N3 (Scheme 1). This catalyst system presents three benefits: (1) it produces neither organic-solvent waste nor metal-contaminated waste; (2) it is unaffected by oxygen and moisture; (3) it enables the aminocarbonylation reaction to meet green chemical requirements.

2. Results

2.1. Coupling Conditions

Upon screening the reaction conditions for the aminocarbonylation in water with the polymeric palladium 1, we found that the reaction efficiency was greatly enhanced by simple reaction conditions. Firstly, we examined the aminocarbonylation in water according to the reported procedures [22]. Thus, the aminocarbonylations of iodobenzene (2a) and NaN3 (3) were carried out in water with PMHS as reducing agent for the generated benzoyl azide in the presence of the polymeric catalyst 1 (5 mol % to Pd) at 50 °C for 8 h under 5 atm of CO gas. The reaction mixture was filtered, and the recovered resin beads were rinsed with a small portion of water and extracted with EtOAc to yield benzamide (4a) in only 13% yield (Entry 1, Table 1).
The scope of suitable bases for the aminocarbonylation in water using catalyst 1 was examined. The potassium carbonate, cesium carbonate, and Et3N produced 9.1%, 17%, and 3.0% yields, respectively (Entries 2–4, Table 1). Next, we tested prolonged reaction times using Cs2CO3, but the yield did not improve as expected (Entry 5, Table 1). In contrast, tripling the time gave a high yield when no base was used (Entry 6, Table 1). The amounts of NaN3 and PMHS were investigated for the aminocarbonylation in water. Thus, the reaction was carried out with 1.0–5.0 equivalents of NaN3 to produce benzamide (4a) in 24%, 48%, 50%, and 46% yields, respectively (Entries 7–10, Table 1). It was surprising to find that, even though PMHS was reduced, the yield remained almost unchanged for this aminocarbonylation, which produced 4a with 43%–53% yields, where the reaction is a one-pot combination of azidocarbonylation and a reduction of generated benzoyl azide with PMHS (Entries 11–16, Table 1). Finally, the highest yield (70%) was obtained when the reaction was performed under simple reaction conditions with 4 equivalents of NaN3 in the presence of 5 mol % of catalyst 1 in water at 45 °C for 24 h under 5 atm of CO gas.

2.2. Substrate Tolerance

With the optimal conditions in hand, we examined polymer-supported terpyridine–palladium-catalyzed aminocarbonylation of several iodoarenes, and the results are summarized in Table 2. The reaction of 2a with sodium azide (3) provided the intended benzamide (4a) in a 70% yield (Entry 1, Table 2), and the reactions with iodobenzene having methyl groups at the ortho-, meta-, and para-positions on the benzene ring also afforded 4-methylbenzamide (4b), 3-methylbenzamide (4c), and 2-methylbenzamide (4d) in 64%, 59%, and 26% yields, respectively (Entries 2–4, Table 2).
The different reaction outcome for 2-substituted iodoarenes 2df is hardly surprising because benzoyl azides bearing an ortho substituent are 50–200 times more reactive toward the Curtius rearrangement than their meta and para isomers [25]. Thus, the reaction of 1-iodonaphthalene (2e) occurred under similar reaction conditions to afford the 1-naphthamide (4e) in a 4.2% yield. iodobenzene derivatives 2gl bearing electron-donating and electron-withdrawing substituents at their para-positions produced 4-methoxybenzamide (4g), 4-trifluoromethylbenzamide (4h), 4-nitrobenzamide (4i), 4-fluorobenzamide (4j), 4-chlorobenzamide (4k), and 4-bromobenzamide (4l) in 41%, 90%, 84%, 82%, 81%, and 65% yields, respectively (Entries 7–12, Table 2). A substrate having an electron-withdrawing substituent tended to produce a high yield.

2.3. Recycling Experiments

The recyclability of catalyst 1 was examined for the aminocarbonylation of 4-iodobenzotrifluoride (2h) with NaN3 (3) (Scheme 2). After the first reaction, which produced 4-(trifluoromethyl)benzamide (4h) in a 90% yield, the catalyst was recovered by simple filtration, washed with H2O, dried under vacuum, and reused five times under similar reaction conditions to afford 4h in 88%, 88%, 87%, 88%, and 88% yields. After the recycling experiments, inductively coupled plasma-atomic emission spectrometry (ICP–AES) analysis showed that the concentration of Pd leached into the aqueous solution was <3 ppm.

3. Discussion

Reaction Mechanism

To clarify the reaction mechanism, we examined the reduction of benzoyl azide (5) with polymeric catalyst 1 (100 mol % Pd) because we postulate that one possible reaction intermediate is the palladacycle (D in Scheme 3). The treatment of 5 with a stoichiometric amount of polymeric PdII catalyst 1 without CO gas did not produce 4a even when the PS–PEG–terpyridine–Pd0(dba) complex was used, but the reaction in the presence of CO gas with a PS–PEG–terpyridine–Pd0 complex or a PS–PEG–terpyridine–PdII complex produced 4a in 95% and 56% yields, respectively (Table 3).
These results suggest that a palladacycle intermediate D derived from terpy–Pd(CO) as a real active species with benzoyl azide is one of the possible reaction intermediates [26,27]; however, if the reaction did not require the use of CO gas, a palladacycle F is also a candidate for a possible reaction intermediate derived from a PS–PEG–terpyridine–Pd0 and benzoyl azide. Based on the present results and reported work [28], we propose a possible reaction pathway for the PS–PEG–terpyridine–Pd catalyzed the aminocarbonylation reaction in water in Scheme 3.
Initially, the oxidative addition of Ar–I to terpy–Pd0(CO) yielded the terpy–PdII(CO)(Ar)(I), which was quickly converted to A via facile CO insertion as shown in cycle 1 of Scheme 3. Transformation of A to B takes place via ligand exchange followed by reductive elimination, which produces complex C. The reaction of C with CO gas afforded terpy–Pd0(CO) and the azidocarbonylation product (ArCON3), which is used in the catalytic Staudinger reaction shown in cycle 2 of Scheme 3 [29]. Thus, the oxidative addition of ArCON3 to terpy–Pd0(CO) yields the palladacycle D followed by the reductive elimination of D to form E, which is transformed to the primary amide in water under CO gas.

4. Materials and Methods

4.1. General Methods

All manipulations were conducted under aerobic conditions. Water was deionized with a Millipore Milli-Q Gradient A10 system (Millipore, Bedford, MA, USA). NMR spectra were recorded on a Bruker AVANCE spectrometer (400 MHz for 1H and 100 MHz for 13C, Bruker, Karsruhe, Germany); 1H and 13C spectra were recorded in dimethyl sulfoxide-d6 (DMSO-d6) at 25 °C. Chemical shifts of 13C are given relative to CDCl3 and DMSO-d6 as internal standards (δ 39.7 ppm). Mass spectra were measured on a JEOL JMS-T100GCv MS detector (GC–MS, JEOL, Tokyo, Japan) and a JEOL JMS-T100LP MS detector (LC–MS, JEOL); the base peak is denoted as “bp.” GC and IR analyses were performed on a Shimadzu GC-2014 instrument (Shimadzu, Kyoto, Japan) and a Jasco FTIR-410 detector (JASCO, Tokyo, Japan), respectively. ICP–AES spectra were measured on a Shimadzu ICPE-9000 instrument (Shimadzu). The high-pressure reaction was performed in an EYELA HIP-7506 autoclave (EYELA, Tokyo, Japan).

4.2. Materials

The PS–PEG-supported terpyridine–palladium complex (PS–PEG–terpyridine–Pd; 1) was prepared from a PS–PEG amino-resin (TentaGel S NH2, average diameter 90 µm, 1% divinylbenzene cross-linked, loading value of amino residue 0.31 mmol/g; purchased from Rapp Polymere, Tuebingen, Germany), a polymeric terpyridine ligand, and (C6H5CN)2PdCl2 in accordance with previously reported procedures [8]. The loading level of Pd in polymeric catalyst 1 was 0.26 mmol/g.

4.3. Aminocarbonylation

The general procedure for obtaining aminocarbonylation products 4al is as described here for 4a. Iodobenzene (2a; 81 mg, 0.40 mmol) was added to a polymeric catalyst mixture (1; 77 mg, 0.020 mmol) and NaN3 (3; 104 mg, 1.60 mmol) in H2O (3.0 mL). The reaction mixture was stirred at 45 °C for 24 h under CO gas (5.0 atm) and filtered. The recovered resin beads were rinsed with H2O and extracted thrice with EtOAc (6 mL). The EtOAc layer was separated, and the aqueous layer was extracted with EtOAc (3 mL). The combined EtOAc extracts were washed with brine (2 mL) and dried over MgSO4; n-dodecane (20 mg) was then added. The GC sample was transferred from the organic layer to a GC vial. The yield of benzamide (4a) determined by GC analysis was 70% with n-dodecane as an internal standard.
The compounds and Chemical Abstracts Service (CAS) registry numbers are as follows: benzamide (4a), 4-methylbenzamide (4b), 3-methylbenzamide (4c), 2-methylbenzamide (4d), 1-naphthamide (4e), 2-nitrobenzamide (4f), 4-methoxybenzamide (4g), 4-trifluoromethylbenzamide (4h), 4-nitrobenzamide (4i), 4-fluorobenzamide (4j), 4-chlorobenzamide (4k), and 4-bromobenzamide (4l); 55-21-0, 619-55-6, 618-47-3, 527-85-5, 2243-81-4, 610-15-1, 3424-93-9, 1891-90-3, 619-8-7, 824-75-9, 619-56-7, and 698-67-9, respectively.

5. Conclusions

We developed a novel polymer-supported terpyridine–palladium complex that efficiently catalyzes the tandem aminocarbonylation of aryl halides with NaN3 in water under CO gas to afford the corresponding primary amides with up to 90% yield via a catalytic azidocarbonylation reaction and catalytic reduction of azide to amine. To the best of our knowledge, this is the first example of a one-pot aminocarbonylation reaction with NaN3 and CO in the presence of the same catalyst via catalytic azidocarbonylation and the Staudinger reaction. The catalyst can be recovered and reused several times with no loss of catalytic activity.
In addition, we studied and described the mechanistic details, which included clarifying why the reaction requires CO gas in catalytic cycle 2 of Scheme 3. We are continuing to investigate the scope of aminocarbonylation with other nucleophiles and possible applications of the catalyst to other organic transformations.


This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number JP16K05871. We thank Akitada Sunagawa and Kanata Tanimoto, undergraduate students, for assistance with some of the lab works.

Author Contributions

Toshimasa Suzuka designed and performed the research and experiments and performed data analysis and manuscript writing and revision. Hiromu Sueyoshi performed the experiments and analyzed the data. Kazuhito Ogihara advised us for this research.

Conflicts of Interest

The authors declare no conflict of interest.


  1. Roy, S.; Roy, S.S.; Gribble, G.W. Metal-catalyzed amidation. Tetrahedron 2012, 68, 9867–9923. [Google Scholar] [CrossRef]
  2. Matsuda, F. Acrylamide production simplified. Chemtech 1977, 7, 306. [Google Scholar]
  3. Opsahl, R. Amide, Fatty Acid, in Encyclopedia of Chemical Technology, 1st ed.; Kroshcitz, J.I., Ed.; Wiley: New York, NY, USA, 1991; Volume 2, pp. 346–356. [Google Scholar]
  4. Gao, L.; Ding, J.; Gao, M.; Wang, Z.; Wu, J.; Li, A. Novel and direct transformation of methyl ketones or carbinols to primary amides by employing aqueous ammonia. Org. Lett. 2009, 11, 3810–3813. [Google Scholar]
  5. Soai, K.; Ookawa, A.; Hayashi, H. Novel functional group selectivity in reductions with lithium borohydride in mixed solvents containing methanol. J. Chem. Soc. Chem. Commun. 1983, 12, 668–669. [Google Scholar] [CrossRef]
  6. Plummer, B.F.; Menendez, M.; Songster, M. Hydration of nitriles to amides promoted by mercury(II) acetate in acetic acid. J. Org. Chem. 1989, 54, 718–719. [Google Scholar] [CrossRef]
  7. Blatt, A.H. The Beckmann rearrangement. Chem. Rev. 1933, 12, 215–260. [Google Scholar]
  8. Davenport, K.G.; Hilton, C.B. Process for Producing N-Acyl-hydroxy Aromatic Amides. U.S. Patent 4,524,217, 18 June 1985. [Google Scholar]
  9. Suzuka, T.; Sueyoshi, H.; Ogiahra, K. Polymer-supported terpyridine–palladium complex for the aminocarbonylation in water of aryl iodides using methoxylamine hydrochloride as an ammonia equivalent. Trans. Mater. Res. Soc. Jpn. 2016, 41, 225–228. [Google Scholar] [CrossRef]
  10. Schoenberg, A.; Heck, R.F. Palladium-catalyzed formylation of aryl, heterocyclic, and vinylic halides. J. Am. Chem. Soc. 1974, 96, 7761–7764. [Google Scholar] [CrossRef]
  11. Brennfuhrer, A.; Neumann, H.; Beller, M. Palladium-catalyzed carbonylation reaction of aryl halides and related compounds. Angew. Chem. Int. Ed. 2009, 48, 4114–4133. [Google Scholar] [CrossRef] [PubMed]
  12. Wu, X.-F.; Neumann, H.; Beller, M. Development of a second generation palladium catalyst system for the aminocarbonylation of aryl halides with CO and ammonia. Chem. Asian J. 2010, 5, 2168–2172. [Google Scholar] [CrossRef] [PubMed]
  13. Wu, X.-F.; Neumann, H.; Beller, M. Selective palladium-catalyzed aminocarbonylation of aryl halides with CO and ammonia. Chem. Eur. J. 2010, 16, 9750–9753. [Google Scholar] [CrossRef] [PubMed]
  14. Morera, E.; Ortar, G. Palladium-catalyzed carbonylative route to primary amides. Tetrahedron Lett. 1998, 39, 2835–2838. [Google Scholar] [CrossRef]
  15. Schnyder, A.; Indolese, A.F. Synthesis of unsymmetrical aroyl acyl imides by aminocarbonylation of aryl bromides. J. Org. Chem. 2002, 67, 594–597. [Google Scholar] [CrossRef] [PubMed]
  16. Ueda, K.; Sato, Y.; Mori, M. Incorporation of N2 and CO into organic molecules: Amide formation by palladium-catalyzed and nitrogenation. J. Am. Chem. Soc. 2000, 122, 10722–10723. [Google Scholar] [CrossRef]
  17. Gadge, S.T.; Bhanage, B.M. A phosphine-free approach to primary amides by palladium-catalyzed aminocarbonylation of aryl and heteroaryl iodides using methoxyamine hydrochloride as an ammonia equivalent. Synlett 2014, 25, 85–88. [Google Scholar]
  18. Suzuka, T.; Adachi, M.; Yang, Z.-S.; Ogihara, K.; Higa, M. Suzuki–Miyaura cross coupling reaction in water with polymer-supported terpyridine palladium complex and application for the synthesis of 2,6-disubstitued pyrimidines. Trans. Mater. Res. Soc. Jpn. 2013, 38, 119–122. [Google Scholar] [CrossRef]
  19. Suzuka, T.; Adachi, M.; Nakamoto, Y.; Ogihara, K. Use of polymer-supported terpyridine–palladium complex for Mizoroki–Heck reaction in water under aerobic conditions. Trans. Mater. Res. Soc. Jpn. 2015, 40, 77–80. [Google Scholar] [CrossRef]
  20. Suzuka, T.; Adachi, M.; Ogihara, K. Sonogashira coupling reaction in water with polymer-supported terpyridine–palladium complex under aerobic conditions. Trans. Mater. Res. Soc. Jpn. 2015, 40, 103–106. [Google Scholar] [CrossRef]
  21. Suzuka, T.; Sueyoshi, H.; Maehara, S.; Ogasawara, H. Reactivity of aryl halides for transfer reduction in (sea)water using polymer-supported terpyridine palladium complex. Molecules 2015, 20, 9906–9914. [Google Scholar] [CrossRef] [PubMed]
  22. Miloserdov, F.M.; Grushin, V.V. Palladium-catalyzed aromatic azidocarbonylation. Angew. Chem. Int. Ed. 2012, 51, 3668–3672. [Google Scholar] [CrossRef] [PubMed]
  23. Kim, Y.J.; Kwak, Y.S.; Lee, S.W. Synthesis and properties of arylpalladium(II) azido complexes PdAr(N3)(PR3)2. Nucleophilic reactions of the azido ligand with CO and with isocyanides to afford Pd(II) isocyanate, C-tetrazolate and carbodiimide complexes. J. Organomet. Chem. 2000, 603, 152–160. [Google Scholar] [CrossRef]
  24. Van Leeuwen, P.W.N.M.; Kamer, P.C.J.; Reek, J.N.H.; Dierkes, P. Lingand bite angle effects in metal-catalyzed C–C bond formation. Chem. Rev. 2000, 100, 2741–2769. [Google Scholar] [CrossRef] [PubMed]
  25. Yukawa, Y.; Tsuno, Y. The Crutius rearrangement. II. The decomposition of o-substituted benzazides in toluene. J. Am. Chem. Soc. 1958, 80, 6346–6350. [Google Scholar] [CrossRef]
  26. Chetcuti, P.A.; Walker, J.A.; Knobler, C.B.; Hawthorne, M.F. Synthesis of metallacycles by 1,3-dipolar cycloaddition reactions between low-valent metal carbonyls and aryl nitrile N-oxides. Organometallics 1988, 7, 641–680. [Google Scholar] [CrossRef]
  27. Cenini, S.; Gallo, E.; Gallo, A.; Caselli, A.; Ragaini, F.; Fantauzzi, S.; Piangiolino, C. Coordination chemistry of organic azides and amination reactions catalyzed by transition metal complexes. Coordination 2006, 250, 1234–1253. [Google Scholar] [CrossRef]
  28. Miloserdov, F.M.; McMullin, C.L.; Belmonte, M.M.; Benet-Buchholz, J.; Bakhmutov, V.I.; Macgregor, S.A.; Grushin, V. The challenge of palladium-catalyzed aromatic azidocarbonylation: From mechanistic and catalyst deactivation studies to a highly efficient process. Organometallics 2014, 33, 736–752. [Google Scholar] [CrossRef]
  29. Van Kalkeren, H.A.; Bruins, J.J.; Rutjes, F.P.J.T.; Van Delft, F.L. Organophosphorus-catalyzed Staudinger reduction. Adv. Synth. Catal. 2012, 354, 1417–1421. [Google Scholar] [CrossRef]
Sample Availability: Samples are not available from the authors.
Scheme 1. Aminocarbonylation in water using polymeric catalyst 1. PS, polystyrene; PEG, poly(ethylene glycol).
Scheme 1. Aminocarbonylation in water using polymeric catalyst 1. PS, polystyrene; PEG, poly(ethylene glycol).
Catalysts 07 00107 sch001
Scheme 2. Recycling experiments.
Scheme 2. Recycling experiments.
Catalysts 07 00107 sch002
Scheme 3. Proposed reaction mechanism of aminocarbonylation in water.
Scheme 3. Proposed reaction mechanism of aminocarbonylation in water.
Catalysts 07 00107 sch003
Table 1. Aminocarbonylation of phenyl iodides with NaN3 using polymeric catalyst 1 in water a.
Table 1. Aminocarbonylation of phenyl iodides with NaN3 using polymeric catalyst 1 in water a.
Catalysts 07 00107 i001
EntryNaN3 (equiv.)Base (equiv.)PMHS (equiv.)Temp. (°C)Time (h)Yield of 4a (%)
a All reactions were performed with 2a (0.4 mmol), NaN3, polymethylhydrosiloxane (PMHS), and polymeric catalyst 1 (5 mol %) in H2O (3.0 mL) under a CO atmosphere. Yields were determined by gas chromatography based on n-dodecane as an internal standard.
Table 2. Aminocarbonylation of aryl iodides with NaN3 using polymeric catalyst 1 in water a.
Table 2. Aminocarbonylation of aryl iodides with NaN3 using polymeric catalyst 1 in water a.
Catalysts 07 00107 i002
Entry24Yield (%) a
1C6H5-I: 2aC6H5-CONH2: 4a70
2p-MeC6H4-I: 2bp-MeC6H4-CONH2: 4b64
3m-MeC6H4-I: 2cm-MeC6H4- CONH2: 4c59
4o-MeC6H4-I: 2do-MeC6H4- CONH2: 4d26
51-iodonaphthalene: 2e1-naphthamide: 4e4.2
6o-NO2C6H4-I: 2fo-NO2C6H4-CONH2: 4f62 b
7p-MeOC6H4-I: 2gp-MeOC6H4-CONH2: 4g41
8p-CF3C6H4-I: 2hp-CF3C6H4-CONH2: 4h90
9p-NO2C6H4-I: 2ip-NO2C6H4-CONH2: 4i84 b
10p-FC6H4-I: 2jp-FC6H4-CONH2: 4j82
11p-ClC6H4-I: 2kp-ClC6H4-CONH2: 4k81 b
12p-BrC6H4-I: 2lp-BrC6H4- CONH2: 4l65
a All reactions were performed with 2 (0.4 mmol), NaN3 (1.6 mmol), and polymeric catalyst 1 (5 mol %) in H2O (3.0 mL) under 5 atm of CO gas. Yields were determined by gas chromatography based on n-dodecane as an internal standard; b isolated yield.
Table 3. Stoichiometric reaction.
Table 3. Stoichiometric reaction.
Catalysts 07 00107 i003
CatalystCO (atm)Yield (%)
PS–PEG–terpyridine–Pd(dba) (1′)595
PS–PEG–terpyridine–Pd(dba) (1′)none0
PS–PEG–terpyridine–Pd+Cl(Cl) (1)556
PS–PEG–terpyridine–Pd+Cl(Cl) (1)none0

Share and Cite

MDPI and ACS Style

Suzuka, T.; Sueyoshi, H.; Ogihara, K. Recyclable Polymer-Supported Terpyridine–Palladium Complex for the Tandem Aminocarbonylation of Aryl Iodides to Primary Amides in Water Using NaN3 as Ammonia Equivalent. Catalysts 2017, 7, 107.

AMA Style

Suzuka T, Sueyoshi H, Ogihara K. Recyclable Polymer-Supported Terpyridine–Palladium Complex for the Tandem Aminocarbonylation of Aryl Iodides to Primary Amides in Water Using NaN3 as Ammonia Equivalent. Catalysts. 2017; 7(4):107.

Chicago/Turabian Style

Suzuka, Toshimasa, Hiromu Sueyoshi, and Kazuhito Ogihara. 2017. "Recyclable Polymer-Supported Terpyridine–Palladium Complex for the Tandem Aminocarbonylation of Aryl Iodides to Primary Amides in Water Using NaN3 as Ammonia Equivalent" Catalysts 7, no. 4: 107.

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop