Next Article in Journal
Performance, Reaction Pathway, and Pretreatment of Au Catalyst Precursor in H2/O2 Atmosphere for the Epoxidation of Propylene
Previous Article in Journal
Different Chiral Ligands Assisted Enantioselective C-H Functionalization with Transition-Metal Catalysts
Article

Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation

Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
*
Author to whom correspondence should be addressed.
Current address: Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, UK.
Academic Editors: Kuan Chang and Consuelo Alvarez-Galvan
Catalysts 2022, 12(5), 538; https://doi.org/10.3390/catal12050538
Received: 15 March 2022 / Revised: 29 April 2022 / Accepted: 6 May 2022 / Published: 14 May 2022
(This article belongs to the Special Issue CO2 Catalytic Conversion and Utilization)
The use of CO2 as a chemical building block is of considerable interest. To achieve carbon fixation at ambient conditions, (de)carboxylase enzymes offer an attractive route but frequently require elevated [CO2] levels to yield the acid product. However, it has recently been shown that the coupling of a UbiD-type decarboxylase with carboxylic acid reductase yields the corresponding aldehyde product at near ambient [CO2]. Here, we show this approach can be expanded to different UbiD and CAR enzymes to yield alternative products, in this case, the production of pyrrole-2-carbaldehyde from pyrrole, using Pseudomonas aeruginosa HudA/PA0254 in combination with Segniliparus rotundus CAR. This confirms the varied substrate range of the respective UbiD and CAR enzymes can be harnessed in distinct combinations to support production of a wide range of aldehydes via enzymatic CO2 fixation. View Full-Text
Keywords: CO2 fixation; biocatalysts; UbiD family (de)carboxylases; carboxylic acid reductases; biocatalytic cascades CO2 fixation; biocatalysts; UbiD family (de)carboxylases; carboxylic acid reductases; biocatalytic cascades
Show Figures

Figure 1

MDPI and ACS Style

Titchiner, G.R.; Marshall, S.A.; Miscikas, H.; Leys, D. Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation. Catalysts 2022, 12, 538. https://doi.org/10.3390/catal12050538

AMA Style

Titchiner GR, Marshall SA, Miscikas H, Leys D. Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation. Catalysts. 2022; 12(5):538. https://doi.org/10.3390/catal12050538

Chicago/Turabian Style

Titchiner, Gabriel R., Stephen A. Marshall, Herkus Miscikas, and David Leys. 2022. "Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation" Catalysts 12, no. 5: 538. https://doi.org/10.3390/catal12050538

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop