Next Article in Journal
A Novel Pd-P Nano-Alloy Supported on Functionalized Silica for Catalytic Aerobic Oxidation of Benzyl Alcohol
Next Article in Special Issue
A Nickel Coated Copper Substrate as a Hydrogen Evolution Catalyst
Previous Article in Journal
Catalytic and Biological Activity of Silver and Gold Complexes Stabilized by NHC with Hydroxy Derivatives on Nitrogen Atoms
Previous Article in Special Issue
Recent Progress on Transition Metal Based Layered Double Hydroxides Tailored for Oxygen Electrode Reactions
 
 
Article

Co Loading Adjustment for the Effective Obtention of a Sedative Drug Precursor through Efficient Continuous-Flow Chemoselective Hydrogenation of 2-Methyl-2-Pentenal

1
Institute of Physical Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, PL-01224 Warsaw, Poland
2
Materials Research Laboratory, Silesian University of Technology, ul. Konarskiego 18A, PL-44100 Gliwice, Poland
3
Faculty of Chemistry, Warsaw University of Technology, ul. Noakowskiego 3, PL-00664 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
Academic Editors: Alessandro Di Michele and Carlo Pirola
Catalysts 2022, 12(1), 19; https://doi.org/10.3390/catal12010019
Received: 30 November 2021 / Revised: 20 December 2021 / Accepted: 22 December 2021 / Published: 25 December 2021
(This article belongs to the Special Issue Transition Metal Catalysis)
This work presents the effect of Co loading on the performance of CNR115 carbon-supported catalysts in the continuous-flow chemoselective hydrogenation of 2-methyl-2-pentenal for the obtention of 2-methylpentanal, an intermediate in the synthesis of the sedative drug meprobamate. The Co loading catalysts (2, 6, 10, and 14 wt.%) were characterized by Brunauer–Emmett–Teller (BET) surface area analysis, transmission electron microscopy (TEM), H2 temperature-programmed reduction (H2-TPR), temperature-programmed desorption of hydrogen (H2-TPD) analysis, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy for selected samples, and have been studied as hydrogenation catalysts at different pressure and temperature ranges. The results reveal that a certain amount of Co is necessary to achieve significant conversion values. However, excessive loading affects the morphological parameters, such as the surface area available for hydrogen adsorption and the particle size, preventing an increase in conversion, despite the increased presence of Co. Moreover, the larger particle size, caused by increasing the loading, alters the chemoselectivity, favouring the formation of 2-methyl-2-pentenol and, thus, decreasing the selectivity towards the desired product. The 6 wt.% Co-loaded material demonstrates the best catalytic performance, which is related to the formation of NPs with optimum size. Almost 100% selectivity towards 2-methylpentanal was obtained for the catalysts with lower Co loading (2 and 6 wt.%). View Full-Text
Keywords: co catalysts; flow chemistry; chemoselective hydrogenation; 2-methyl-2-pentenal; meprobamate co catalysts; flow chemistry; chemoselective hydrogenation; 2-methyl-2-pentenal; meprobamate
Show Figures

Graphical abstract

MDPI and ACS Style

Fernández-Ropero, A.J.; Zawadzki, B.; Matus, K.; Patkowski, W.; Krawczyk, M.; Lisovytskiy, D.; Raróg-Pilecka, W.; Śrębowata, A. Co Loading Adjustment for the Effective Obtention of a Sedative Drug Precursor through Efficient Continuous-Flow Chemoselective Hydrogenation of 2-Methyl-2-Pentenal. Catalysts 2022, 12, 19. https://doi.org/10.3390/catal12010019

AMA Style

Fernández-Ropero AJ, Zawadzki B, Matus K, Patkowski W, Krawczyk M, Lisovytskiy D, Raróg-Pilecka W, Śrębowata A. Co Loading Adjustment for the Effective Obtention of a Sedative Drug Precursor through Efficient Continuous-Flow Chemoselective Hydrogenation of 2-Methyl-2-Pentenal. Catalysts. 2022; 12(1):19. https://doi.org/10.3390/catal12010019

Chicago/Turabian Style

Fernández-Ropero, Antonio Jesús, Bartosz Zawadzki, Krzysztof Matus, Wojciech Patkowski, Mirosław Krawczyk, Dmytro Lisovytskiy, Wioletta Raróg-Pilecka, and Anna Śrębowata. 2022. "Co Loading Adjustment for the Effective Obtention of a Sedative Drug Precursor through Efficient Continuous-Flow Chemoselective Hydrogenation of 2-Methyl-2-Pentenal" Catalysts 12, no. 1: 19. https://doi.org/10.3390/catal12010019

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop