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Open AccessArticle

Effects of Long-Term Supplementation with Aluminum or Selenium on the Activities of Antioxidant Enzymes in Mouse Brain and Liver

1
Neuroscience Institute, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania
2
Department of Biochemistry, Medical Academy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania
*
Author to whom correspondence should be addressed.
Catalysts 2020, 10(5), 585; https://doi.org/10.3390/catal10050585
Received: 8 April 2020 / Revised: 20 May 2020 / Accepted: 20 May 2020 / Published: 23 May 2020
(This article belongs to the Special Issue Biocatalytic Process Optimization)
The aim of this study was to investigate the effects of aluminum (Al) or selenium (Se) on the “primary” antioxidant defense system enzymes (superoxide dismutase, catalase, and glutathione reductase) in cells of mouse brain and liver after long-term (8-week) exposure to drinking water supplemented with AlCl3 (50 mg or 100 mg Al/L in drinking water) or Na2SeO3 (0.2 mg or 0.4 mg Se/L in drinking water). Results have shown that a high dose of Se increased the activities of superoxide dismutase and catalase in mouse brain and liver. Exposure to a low dose of Se resulted in an increase in catalase activity in mouse brain, but did not show any statistically significant changes in superoxide dismutase activity in both organs. Meanwhile, the administration of both doses of Al caused no changes in activities of these enzymes in mouse brain and liver. The greatest sensitivity to the effect of Al or Se was exhibited by glutathione reductase. Exposure to both doses of Al or Se resulted in statistically significant increase in glutathione reductase activity in both brain and liver. It was concluded that 8-week exposure to Se caused a statistically significant increase in superoxide dismutase, catalase and glutathione reductase activities in mouse brain and/or liver, however, these changes were dependent on the used dose. The exposure to both Al doses caused a statistically significant increase only in glutathione reductase activity of both organs. View Full-Text
Keywords: superoxide dismutase (SOD); catalase (CAT); glutathione reductase (GR); aluminum (Al); selenium (Se); mouse; brain; liver superoxide dismutase (SOD); catalase (CAT); glutathione reductase (GR); aluminum (Al); selenium (Se); mouse; brain; liver
MDPI and ACS Style

Sadauskiene, I.; Liekis, A.; Staneviciene, I.; Naginiene, R.; Ivanov, L. Effects of Long-Term Supplementation with Aluminum or Selenium on the Activities of Antioxidant Enzymes in Mouse Brain and Liver. Catalysts 2020, 10, 585.

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