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Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020)

by Sijia Chen 1,†, Chongguo Jiang 1,†, Nan Zheng 1, Zhen Yang 1,2,3,* and Lili Shi 1,*
1
State Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China
2
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
3
Shenzhen Bay Laboratory, Shenzhen 518055, China
*
Authors to whom correspondence should be addressed.
Sijia Chen and Chongguo Jiang have contributed equally to this work.
Catalysts 2020, 10(10), 1199; https://doi.org/10.3390/catal10101199
Received: 23 September 2020 / Revised: 10 October 2020 / Accepted: 14 October 2020 / Published: 16 October 2020
Metal-mediated cyclizations are important transformations in a natural product total synthesis. The Pauson-Khand reaction, particularly powerful for establishing cyclopentenone-containing structures, is distinguished as one of the most attractive annulation processes routinely employed in synthesis campaigns. This review covers Co, Rh, and Pd catalyzed Pauson-Khand reaction and summarizes its strategic applications in total syntheses of structurally complex natural products in the last five years. Additionally, the hetero-Pauson-Khand reaction in the synthesis of heterocycles will also be discussed. Focusing on the panorama of organic synthesis, this review highlights the strategically developed Pauson-Khand reaction in fulfilling total synthetic tasks and its synthetic attractiveness is aimed to be illustrated. View Full-Text
Keywords: metal-mediated reactions; Pauson-Khand reaction; cyclopentenones; natural products total syntheses metal-mediated reactions; Pauson-Khand reaction; cyclopentenones; natural products total syntheses
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MDPI and ACS Style

Chen, S.; Jiang, C.; Zheng, N.; Yang, Z.; Shi, L. Evolution of Pauson-Khand Reaction: Strategic Applications in Total Syntheses of Architecturally Complex Natural Products (2016–2020). Catalysts 2020, 10, 1199.

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