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Cancers 2017, 9(1), 10;

Stromal Androgen Receptor in Prostate Cancer Development and Progression

The Basil Hetzel Institute for Translational Health Research, The University of Adelaide, Adelaide 5011, Australia
Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
Department of Radiation Oncology, Canberra Teaching Hospital, Canberra 2605, Australia
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel S. Antonarakis
Received: 30 November 2016 / Revised: 13 January 2017 / Accepted: 16 January 2017 / Published: 22 January 2017
(This article belongs to the Special Issue AR Signaling in Human Malignancies: Prostate Cancer and Beyond)
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Prostate cancer development and progression is the result of complex interactions between epithelia cells and fibroblasts/myofibroblasts, in a series of dynamic process amenable to regulation by hormones. Whilst androgen action through the androgen receptor (AR) is a well-established component of prostate cancer biology, it has been becoming increasingly apparent that changes in AR signalling in the surrounding stroma can dramatically influence tumour cell behavior. This is reflected in the consistent finding of a strong association between stromal AR expression and patient outcomes. In this review, we explore the relationship between AR signalling in fibroblasts/myofibroblasts and prostate cancer cells in the primary site, and detail the known functions, actions, and mechanisms of fibroblast AR signaling. We conclude with an evidence-based summary of how androgen action in stroma dramatically influences disease progression. View Full-Text
Keywords: prostate cancer; stroma; fibroblasts; androgen; androgen receptor prostate cancer; stroma; fibroblasts; androgen; androgen receptor

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Leach, D.A.; Buchanan, G. Stromal Androgen Receptor in Prostate Cancer Development and Progression. Cancers 2017, 9, 10.

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