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Open AccessReview

Radioresistance of Brain Tumors

Radiation Medicine Department, Hofstra Northwell School of Medicine, Northwell Health, Manhasset, NY 11030, USA
The Feinstein Institute for Molecular Medicine, Hofstra Northwell School of Medicine, Northwell Health, Manhasset, NY 11030, USA
Authors to whom correspondence should be addressed.
Academic Editor: Zhe-Sheng (Jason) Chen
Cancers 2016, 8(4), 42;
Received: 17 January 2016 / Revised: 10 March 2016 / Accepted: 24 March 2016 / Published: 30 March 2016
(This article belongs to the Special Issue Drug/Radiation Resistance in Cancer Therapy)
PDF [767 KB, uploaded 30 March 2016]


Radiation therapy (RT) is frequently used as part of the standard of care treatment of the majority of brain tumors. The efficacy of RT is limited by radioresistance and by normal tissue radiation tolerance. This is highlighted in pediatric brain tumors where the use of radiation is limited by the excessive toxicity to the developing brain. For these reasons, radiosensitization of tumor cells would be beneficial. In this review, we focus on radioresistance mechanisms intrinsic to tumor cells. We also evaluate existing approaches to induce radiosensitization and explore future avenues of investigation. View Full-Text
Keywords: radiation therapy; radioresistance; brain tumors radiation therapy; radioresistance; brain tumors

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Kelley, K.; Knisely, J.; Symons, M.; Ruggieri, R. Radioresistance of Brain Tumors. Cancers 2016, 8, 42.

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