Melanoma Cancer Stem Cells: Markers and Functions
AbstractThe discovery of cancer stem cells (CSCs) in human solid tumors has allowed a better understanding of the biology and neoplastic transformation of normal melanocytes, and the possible mechanisms by which melanoma cells acquire tumorigenicity. In this review I summarize the literature findings on the potential biomarkers of melanoma CSCs, their presence in the melanoma cell populations, the interaction with the immune system (with both T and NK cells) and the role of melanoma CSCs in the clinics. Given the extraordinary progress in the therapy of melanoma caused by immune checkpoint antibodies blockade, I discuss how these antibodies can work by the activation of melanoma infiltrating T cells specifically recognizing neo-antigens expressed even by melanoma CSCs. This is the mechanism that can induce a regression of the metastatic melanomas. View Full-Text
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Parmiani, G. Melanoma Cancer Stem Cells: Markers and Functions. Cancers 2016, 8, 34.
Parmiani G. Melanoma Cancer Stem Cells: Markers and Functions. Cancers. 2016; 8(3):34.Chicago/Turabian Style
Parmiani, Giorgio. 2016. "Melanoma Cancer Stem Cells: Markers and Functions." Cancers 8, no. 3: 34.
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