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Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

Department of Surgery, Division of Pediatric Surgery, University of Alabama, Birmingham, AL 35233, USA
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Author to whom correspondence should be addressed.
Academic Editor: Vita Golubovskaya
Received: 21 November 2015 / Revised: 16 December 2015 / Accepted: 21 December 2015 / Published: 31 December 2015
(This article belongs to the Special Issue Cancer Stem Cells and Tumor Microenvironment)
Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease. View Full-Text
Keywords: neuroblastoma; cancer stem cell; cancer-associated fibroblasts; hypoxia neuroblastoma; cancer stem cell; cancer-associated fibroblasts; hypoxia
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MDPI and ACS Style

Garner, E.F.; Beierle, E.A. Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma. Cancers 2016, 8, 5. https://doi.org/10.3390/cancers8010005

AMA Style

Garner EF, Beierle EA. Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma. Cancers. 2016; 8(1):5. https://doi.org/10.3390/cancers8010005

Chicago/Turabian Style

Garner, Evan F., and Elizabeth A. Beierle 2016. "Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma" Cancers 8, no. 1: 5. https://doi.org/10.3390/cancers8010005

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