Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer
Abstract
:1. Introduction
2. The Role of the Hedgehog Pathway in Prostate Cancer
3. Clinical Experience with Hedgehog Inhibitors in Prostate Cancer
National Clinical Trial Number | Target Population | Trial Name | Primary Endpoint | Status |
---|---|---|---|---|
NCT02111187 | Localized disease/neoadjuvant | A Pre-surgical Study of Sonidegib in Men with High-risk Localized Prostate Cancer | Change from baseline in tissue GLI1 expression levels | Currently accruing |
NCT01163084 | Localized disease/neoadjuvant | Leuprolide Acetate or Goserelin Acetate With or Without Vismodegib Followed by Surgery in Treating Patients with Locally Advanced Prostate Cancer | Proportion of patients with less than 5% tumor involvement on prostatectomy | Active, not recruiting |
NCT01787331 | Rising PSA | A Phase II Study of Itraconazole in Biochemical Relapse | Proportion of patients who achieve greater than 50% decline in PSA | Currently accruing |
NCT02115828 | Castration-resistant prostate cancer | A Pharmacodynamic Study of Vismodegib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC) With Accessible Metastatic Lesions for Tumor Biopsy | Proportion of patients with at least a 50% reduction in tumor GLI1 expression level from baseline | Currently Accruing |
NCT02182622 | Castration-resistant prostate cancer | Sonidegib combined with Docetaxel for Met Castrate Resistant Prostate Cancer w/Disease Progression after Docetaxel | Maximum Tolerated Dose (MTD) | Not yet accruing |
4. Future Directions
Acknowledgments
Conflicts of Interest
References
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Suzman, D.L.; Antonarakis, E.S. Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer. Cancers 2015, 7, 1983-1993. https://doi.org/10.3390/cancers7040871
Suzman DL, Antonarakis ES. Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer. Cancers. 2015; 7(4):1983-1993. https://doi.org/10.3390/cancers7040871
Chicago/Turabian StyleSuzman, Daniel L., and Emmanuel S. Antonarakis. 2015. "Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer" Cancers 7, no. 4: 1983-1993. https://doi.org/10.3390/cancers7040871