Next Article in Journal
The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells
Next Article in Special Issue
Involvement of 14-3-3 Proteins in Regulating Tumor Progression of Hepatocellular Carcinoma
Previous Article in Journal
The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma

Voltage-Gated Ion Channels in Cancer Cell Proliferation

Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago 2160 S. 1s tAve, Maywood, IL 60153, USA
Department of Ophthalmology and Vision Research Center, School of Medicine, University of Missouri-Kansas City, 2411 Holmes St., Kansas City, MO 64108, USA
Author to whom correspondence should be addressed.
Academic Editor: Vita Golubovskaya
Cancers 2015, 7(2), 849-875;
Received: 30 March 2015 / Accepted: 12 May 2015 / Published: 22 May 2015
(This article belongs to the Special Issue Cancer Cell Proliferation)
Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions. The opening of ion channels alter the charge distribution across the surface membrane as they allow the diffusion of ions such as K+, Ca++, Cl, Na+. Traditionally, voltage-gated ion channels (VGIC) are known to play fundamental roles in controlling rapid bioelectrical signaling including action potential and/or contraction. However, several investigations have revealed that these classes of proteins can also contribute significantly to cell mitotic biochemical signaling, cell cycle progression, as well as cell volume regulation. All these functions are critically important for cancer cell proliferation. Interestingly, a variety of distinct VGICs are expressed in different cancer cell types, including metastasis but not in the tissues from which these tumors were generated. Given the increasing evidence suggesting that VGIC play a major role in cancer cell biology, in this review we discuss the role of distinct VGIC in cancer cell proliferation and possible therapeutic potential of VIGC pharmacological manipulation. View Full-Text
Keywords: cancer; cell proliferation; voltage gated ion channel; membrane potential cancer; cell proliferation; voltage gated ion channel; membrane potential
Show Figures

Graphical abstract

MDPI and ACS Style

Rao, V.R.; Perez-Neut, M.; Kaja, S.; Gentile, S. Voltage-Gated Ion Channels in Cancer Cell Proliferation. Cancers 2015, 7, 849-875.

AMA Style

Rao VR, Perez-Neut M, Kaja S, Gentile S. Voltage-Gated Ion Channels in Cancer Cell Proliferation. Cancers. 2015; 7(2):849-875.

Chicago/Turabian Style

Rao, Vidhya R., Mathew Perez-Neut, Simon Kaja, and Saverio Gentile. 2015. "Voltage-Gated Ion Channels in Cancer Cell Proliferation" Cancers 7, no. 2: 849-875.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop