Cutaneous Squamous Cell Carcinoma in Epidermolysis Bullosa: A Review of Pathogenesis, Diagnosis and Management
Simple Summary
Abstract
1. Introduction
2. Subtypes of Epidermolysis Bullosa
2.1. EB Simplex
2.2. Junctional EB
2.3. Dystrophic EB
2.4. Kindler Syndrome
2.5. Acquired EB
3. Cutaneous Squamous Cell Carcinoma
3.1. Pathophysiology of cSCC
3.2. Pathophysiology of cSCC in EB
3.3. Clinical Presentation of cSCC in EB
4. Diagnosis of EB-Associated cSCC
5. Management and Treatment
5.1. Surgical Excision
5.2. Immunotherapy
5.3. Anti-EGFR Therapy
5.4. Electrochemotherapy
5.5. Palliative Care
6. Surveillance and Prevention
7. Future Directions and Research Needs
8. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Chandrasekaran, A.; Moser, J.C. Cutaneous Squamous Cell Carcinoma in Epidermolysis Bullosa: A Review of Pathogenesis, Diagnosis and Management. Cancers 2025, 17, 3211. https://doi.org/10.3390/cancers17193211
Chandrasekaran A, Moser JC. Cutaneous Squamous Cell Carcinoma in Epidermolysis Bullosa: A Review of Pathogenesis, Diagnosis and Management. Cancers. 2025; 17(19):3211. https://doi.org/10.3390/cancers17193211
Chicago/Turabian StyleChandrasekaran, Abarajithan, and Justin C. Moser. 2025. "Cutaneous Squamous Cell Carcinoma in Epidermolysis Bullosa: A Review of Pathogenesis, Diagnosis and Management" Cancers 17, no. 19: 3211. https://doi.org/10.3390/cancers17193211
APA StyleChandrasekaran, A., & Moser, J. C. (2025). Cutaneous Squamous Cell Carcinoma in Epidermolysis Bullosa: A Review of Pathogenesis, Diagnosis and Management. Cancers, 17(19), 3211. https://doi.org/10.3390/cancers17193211