Evaluation of Treatment Modalities and Oncologic Outcomes in Hand Soft Tissue Sarcomas—A Systematic Review of the Literature
Abstract
Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Eligibility Criteria
2.3. Selection, Data Collection, and Extraction Process
2.4. Study Selection and Patient Characteristics
2.5. Assessment of Study Quality
2.6. Statistical Analysis
3. Results
3.1. Surgical Management
3.2. (Neo)-Adjuvant Therapy
3.3. Oncologic Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
C | Carpal |
F | Female |
FU | Follow-up |
M:F | Male-to-Female |
MC | Metacarpal |
P | Phalangeal |
W | Wrist |
ES | Epithelioid Sarcoma |
FS | Fibrosarcoma |
LMS | Leiomyosarcoma |
MFS | Myxofibrosarcoma |
SS | Synovial Sarcoma |
UPS | Undifferentiated Pleomorphic Sarcoma |
STROBE | Strengthening the Reporting of Observational Studies in Epidemiology |
LSS | Limb Salvage Surgery |
QT | Chemotherapy |
RT | Radiotherapy |
STS | Soft Tissue Sarcoma |
UE | Unplanned Excision |
References
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Author | Sample (n) | Mean Age (years) | M:F Ratio | Location | Mean Tumor Size (cm) | Deep (Sub-Fascial) | Localized | Metastatic | High-Grade | Mean FU (Years) |
---|---|---|---|---|---|---|---|---|---|---|
Chapman et al. [1] | 109 | 36 | 0.98 | - | 2.1 α | 88% | 96.3% | 3.7% | 64% | 6.1 |
Farzaliyev et al. [17] | 23 | 27 | 1.3 | W (48%), MC (35%), P (17%) | - | - | - | - | - | 7 |
Thumser et al. [5] | 16 | 40 | 1.67 | - | 5 | - | 100.0% | 0.0% | 94% | 6 |
Dadras et al. [12] | 51 | 41 | 1.21 | MC (47%), W (35%), P (18%) | 2.2 | 64% | - | - | 69% | 6.5 α |
Lans et al. [18] | 64 | 46 | - | MC (64%), P (28%), C (8%) | 3 | 27% | - | - | 70% | 4 |
Dean et al. [19] | 26 | 50 | 1.36 | - | 2.7 α | - | - | - | 67% | 4.9 |
Nicholson et al. [16] | 17 | 45 | 0.88 | C (52%), W (30%), P (18%) | 2.2 | - | 94.0% | 6.0% | 47% | 2 |
Houdek et al. [20] | 46 | 38 | 0.91 | C or W (56%), P (44%) | - | 40% | 91.4% | 8.6% | - | 5 |
Mirous et al. [21] | 16 | 49 | 3 | W (56%), MC (44%) | - | - | - | - | 63% | 4.5 |
Wang et al. [11] | 13 | 55 | 1.1 | - | - | - | 100.0% | 0.0% | - | 4 |
Deroose et al. [22] | 10 | 51 | 0.66 | C (60%), W (30%), P (10%) | - | - | - | - | 80% | 3 |
Pradhan et al. [14] | 63 | 45 | 0.43 | MC (43%), P (25%), C (22%) | 4 | 45% | 100.0% | 0.0% | 68% | 4 |
Michal et al. [24] | 13 | 32 | 0.625 | C (38%), MC (32%), P (30%) | 1 | - | - | - | - | 14.7 |
Herr et al. [23] | 28 | 31 | 1.8 | P (53%), C (25%), W (21%) | 2.5 α | - | - | - | - | 10 |
McPhee et al. [15] | 24 | 39 | 2 | W (50%), C (33%), P (16%) | - | - | 80.0% | 20.0% | 91% | 7 |
Gross et al. [10] | 18 | 18 | 1.57 | MC (88%), P (12%) | - | - | - | - | 78% | 5.5 |
Brien et al. [13] | 23 | 31 | 1.3 | P (47%), C (34%), W (17%), MC (2%) | - | 65% | 83.0% | 17.0% | 86% | 3 |
Prat et al. [8] | 10 | 28 | 4 | MC (60%), P (40%) | 2.6 | 5% | - | - | - | 8 |
Author (Year) | Sample (n) | ES | SS | UPS | FS | LMS | MFS | Other |
---|---|---|---|---|---|---|---|---|
Chapman et al. [1] | 109 | 25% | 16% | 4% | 4% | 5% | 7% | 40% |
Farzaliyev et al. [17] | 23 | 100% | 0% | 0% | 0% | 0% | 0% | 0% |
Thumser et al. [5] | 16 | 31% | 19% | 0% | 0% | 6% | 6% | 38% |
Dadras et al. [12] | 51 | 14% | 26% | 10% | 2% | 6% | 6% | 35% |
Lans et al. [18] | 64 | 20% | 16% | 13% | 11% | 5% | 0% | 38% |
Dean et al. [19] | 26 | 35% | 8% | 8% | 0% | 12% | 15% | 23% |
Nicholson et al. [16] | 17 | 6% | 18% | 0% | 0% | 12% | 18% | 47% |
Houdek et al. [20] | 46 | 22% | 17% | 4% | 15% | 7% | 0% | 35% |
Mirous et al. [21] | 16 | 13% | 19% | 6% | 0% | 13% | 6% | 44% |
Wang et al. [11] | 13 | 8% | 15% | 0% | 23% | 15% | 0% | 39% |
Deroose et al. [22] | 10 | 50% | 20% | 0% | 0% | 0% | 0% | 30% |
Pradhan et al. [14] | 63 | 18% | 16% | 0% | 11% | 5% | 0% | 51% |
Michal et al. [24] | 13 | 0% | 100% | 0% | 0% | 0% | 0% | 0% |
Herr et al. [23] | 28 | 100% | 0% | 0% | 0% | 0% | 0% | 0% |
McPhee et al. [15] | 24 | 25% | 8% | 0% | 0% | 0% | 0% | 67% |
Gross et al. [10] | 18 | 11% | 6% | 0% | 0% | 0% | 0% | 83% |
Brien et al. [13] | 23 | 9% | 35% | 13% | 0% | 13% | 0% | 30% |
Prat et al. [8] | 10 | 100% | 0% | 0% | 0% | 0% | 0% | 0% |
Weighted percentage | 570 | 28% | 17% | 4% | 5% | 5% | 4% | 37% |
Author | Setting | Participants | Variables | Data Sources | Statistical Methods | Participants | Descriptive Data | Outcome Data | Main Results | Limitations | Score |
---|---|---|---|---|---|---|---|---|---|---|---|
Chapman et al. [1] | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 19 |
Farzaliyev et al. [17] | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 18 |
Thumser et al. [5] | 2 | 2 | 2 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 17 |
Dadras et al. [12] | 2 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 16 |
Lans et al. [18] | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 18 |
Dean et al. [19] | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 16 |
Nicholson et al. [16] | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 0 | 16 |
Houdek et al. [20] | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 2 | 17 |
Mirous et al. [21] | 2 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 16 |
Wang et al. [11] | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 18 |
Deroose et al. [22] | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 1 | 18 |
Pradhan et al. [14] | 2 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 16 |
Michal et al. [24] | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 16 |
Herr et al. [23] | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 17 |
McPhee et al. [15] | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 17 |
Gross et al. [10] | 2 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 16 |
Brien et al. [13] | 2 | 2 | 1 | 2 | 1 | 2 | 2 | 2 | 2 | 1 | 17 |
Prat et al. [8] | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 17 |
Author | Prior UE | RT | QT | LSS | Amputation | Positive Margins |
---|---|---|---|---|---|---|
Chapman et al. [1] | - | 33% | 12% | 54% | 46% | 6% |
Farzaliyev et al. [17] | 87% | 52% | 22% | 87% | 13% | 30% |
Thumser et al. [5] | - | 50% | 70% | 30% | 70% | 6% |
Dadras et al. [12] | 67% | 33% | 25% | 100% | 0% | 12% |
Lans et al. [18] | 81% | 59% | 6% | 98% | 2% | 14% |
Dean et al. [19] | 46% | 27% | 4% | 73% | 27% | - |
Nicholson et al. [16] | 41% | 59% | 8% | 100% | 0% | - |
Houdek et al. [20] | 72% | 52% | 24% | 87% | 13% | 0% |
Mirous et al. [21] | 63% | 56% | 31% | 100% | 0% | - |
Wang et al. [11] | 39% | 8% | 38% | 100% | 0% | - |
Deroose et al. [22] | 40% | 40% | 0% | 100% | 0% | 30% |
Pradhan et al. [14] | 16% | 36% | 4% | 71% | 29% | 42% |
Michal et al. [24] | - | 38% | 8% | - | 8% | - |
Herr et al. [23] | 35% | 21% | 7% | 15% | 88% | 12% |
McPhee et al. [15] | - | 16% | 13% | 60% | 40% | - |
Gross et al. [10] | 100% | 61% | 11% | 72% | 28% | 22% |
Brien et al. [13] | - | 60% | 34% | 66% | 34% | 34% |
Prat et al. [8] | - | 30% | 80% | 90% | 10% | 10% |
Weighted percentage | 57% | 40% | 17% | 74% | 26% | 16% |
Author | Metastasis | Local Recurrence | Overall Survival | Disease-Free Survival | ||||
---|---|---|---|---|---|---|---|---|
2-Year | 5-Year | 10-Year | 2-Year | 5-Year | 10-Year | |||
Chapman et al. [1] | 6% | 4% | 100% | 95% | 92% | 95% | 89% | 88% |
Farzaliyev et al. [17] | 39% | 30% | - | - | - | - | 90% | 62% |
Thumser et al. [5] | 43% | 12% | 87% | 56% | 13% | - | - | - |
Dadras et al. [12] | 16% | 35% | - | - | 91% | - | 91% | 91% |
Lans et al. [18] | 23% | 13% | - | 83% | 83% | - | 69% | 65% |
Dean et al. [19] | 27% | 19% | - | 86% | - | - | - | - |
Nicholson et al. [16] | 29% | 12% | 92% | - | - | 62% | - | - |
Houdek et al. [20] | 30% | 11% | 96% | 78% | 72% | 71% | 63% | 63% |
Mirous et al. [21] | 6% | 13% | - | 94% | - | - | - | - |
Wang et al. [11] | 8% | 8% | 92% | - | - | - | 85% | - |
Deroose et al. [22] | - | 30% | 90% | 60% | 60% | - | - | - |
Pradhan et al. [14] | 22% | 32% | - | 87% | 71% | - | - | - |
Michal et al. [24] | 0% | 15% | - | - | - | - | - | - |
Herr et al. [23] | 32% | 4% | - | 85% | 85% | - | 67% | 67% |
McPhee et al. [15] | 25% | 41% | - | 59% | 53% | - | - | - |
Gross et al. [10] | 39% | 61% | 61% | 55% | 55% | 50% | 50% | 50% |
Brien et al. [13] | 17% | 35% | 93% | 50% | - | - | - | - |
Prat et al. [8] | 50% | 50% | 60% | 50% | 40% | 30% | 30% | 30% |
Weighted percentage | 21% | 20% | 92% | 80% | 77% | 79% | 77% | 74% |
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Calmet Rocca, W.R.; Kuthiala, R.S.; Gonzalez, M.R.; Pretell-Mazzini, J. Evaluation of Treatment Modalities and Oncologic Outcomes in Hand Soft Tissue Sarcomas—A Systematic Review of the Literature. Cancers 2025, 17, 3204. https://doi.org/10.3390/cancers17193204
Calmet Rocca WR, Kuthiala RS, Gonzalez MR, Pretell-Mazzini J. Evaluation of Treatment Modalities and Oncologic Outcomes in Hand Soft Tissue Sarcomas—A Systematic Review of the Literature. Cancers. 2025; 17(19):3204. https://doi.org/10.3390/cancers17193204
Chicago/Turabian StyleCalmet Rocca, W. Rodrigo, Rayna S. Kuthiala, Marcos R. Gonzalez, and Juan Pretell-Mazzini. 2025. "Evaluation of Treatment Modalities and Oncologic Outcomes in Hand Soft Tissue Sarcomas—A Systematic Review of the Literature" Cancers 17, no. 19: 3204. https://doi.org/10.3390/cancers17193204
APA StyleCalmet Rocca, W. R., Kuthiala, R. S., Gonzalez, M. R., & Pretell-Mazzini, J. (2025). Evaluation of Treatment Modalities and Oncologic Outcomes in Hand Soft Tissue Sarcomas—A Systematic Review of the Literature. Cancers, 17(19), 3204. https://doi.org/10.3390/cancers17193204