Leiomyogenic Tumor of the Spine: A Systematic Review
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Literature Search
2.2. Study Selection
- Included at least one patient diagnosed with a leiomyogenic tumor affecting the spine as a primary tumor or originating from a primary non-spinal leiomyoma, based on radiological, clinical, or pathological diagnosis;
- Reported data on clinical aspects, treatment, and outcomes;
- Were written in the English language.
- Were reviews, autopsy reports, or focused on animal studies;
- Involved patients with spinal LMs originating from primary CNS tumors;
- Failed to differentiate data of patients with spine LMs from those with only intra-cranial LMs;
- Lacked sufficient data regarding treatment outcomes.
2.3. Data Extraction
2.4. Data Synthesis and Quality Assessment
3. Results
3.1. Study Selection and Overview
3.2. Demographics and Primary Tumors’ Characteristics
3.3. Clinical and Diagnostic Features of Spine LTS
3.4. Management Strategies
3.5. Treatment Outcomes and Survival
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Presenting Characteristics (n = 83) | Value [Percentage among Available Data] |
---|---|
Demographics | |
Age (y), mean ± SD | 49.55 ± 13.72 |
Sex (n = 83) | Male: 23 [27.71%] Female: 60 [72.29%] |
Comorbidities | 5 [6.02%] |
HIV | 2 [2.41%] |
Trauma | 1 [1.20%] |
Past history of uterine neoplasia | 28 [33.73%] |
Most reported symptoms | |
Back pain | 48 [57.83%] |
Leg Pain | 1 [1.20%] |
Lower-extremity paralysis | 8 [9.64%] |
Lower-extremity weakness | 18 [21.69%] |
Urinary symptoms | 4 [4.82%] |
Radicular pain | 15 [18.07%] |
Neck pain | 4 [4.82%] |
Spasms | 1 [1.20%] |
Upper-extremity pain | 4 [4.82%] |
Paraparesis | 4 [4.82%] |
Paraplegia | 2 [2.41%] |
Claudication | 2 [2.41%] |
Hip pain | 5 [6.02%] |
Other symptoms | 2 [2.41%] |
Tumor Location (n = 83) | |
Thoracic region | 43 [51.81%] |
Cervical region | 6 [7.23%] |
Lumbar region | 18 [21.67%] |
Sacral region | 3 [3.61%] |
Cervicothoracic | 2 [2.41%] |
Thoracolumbar | 5 [6.02%] |
Lumbosacral | 4 [4.82%] |
Unreported data | 2 [2.41%] |
Imaging Modalities (n = 48) | |
CT alone | 3 [6.25%] |
MRI alone | 16 [33.33%] |
CT + MRI | 11 [22.92%] |
CT + MRI + X-ray | 8 [16.67%] |
CT + MRI + PET | 5 [10.42%] |
MRI + X-ray | 1 [2.08%] |
MRI + PET | 2 [4.17%] |
MRI + X-ray + PET | 1 [2.08%] |
CT + X-ray + Myelography | 1 [2.08%] |
Tumor type (n = 56) | |
Primary tumor | 18 [32.14%] |
Metastatic disease | 38 [67.86%] |
Biopsy Results (n = 61) | |
Leiomyosarcoma | 48 [78.69%] |
Benign Leiomyoma | 13 [21.31%] |
Histological Markers (n = 83) | Value [Percentage among Available Data] | ||
---|---|---|---|
Positive | Negative | Not Measured | |
Actin | 36 [43.37%] | 1 [1.20%] | 46 [55.42%] |
Desmin | 26 [31.33%] | 3 [3.61%] | 53 [63.64%] |
Caldesmin | 7 [10.23%] | 3 [3.61%] | 73 [87.95%] |
CD10 | 1 [1.20%] | 2 [2.41%] | 80 [96.39%] |
Estrogen/Progesterone | 10 [12.05%] | 3 [3.61%] | 70 [84.34%] |
Ki67 | 21 [25.30%] | 2 [2.41%] | 60 [72.29%] |
Melanoma-Black 45 | 0 [0.00%] | 2 [2.41%] | 81 [97.59%] |
Collegen IV | 1 [1.20%] | 0 [0.00%] | 82 [98.80%] |
p16 | 1 [1.20%] | 0 [0.00%] | 82 [98.80%] |
p53 | 1 [1.20%] | 0 [0.00%] | 82 [98.80%] |
s100 | 1 [1.20%] | 20 [24.10%] | 62 [74.70%] |
SOX10 | 0 [0.00%] | 2 [2.41%] | 81 [97.59%] |
CD34 | 2 [2.41%] | 6 [7.23%] | 75 [90.36%] |
Treatment Data | Value [Percentage among Available Data] |
---|---|
Primary Surgery Type (n = 78) | |
Resection + Fixation | 15 [19.23%] |
Total en bloc spondylectomy | 12 [15.38%] |
Corpectomy | 8 [10.26%] |
Laminectomy + Resection | 7 [8.97%] |
Laminectomy + Fixation | 3 [3.85%] |
Laminectomy + Decompression | 1 [1.28%] |
Laminectomy + Fixation + Resection | 7 [8.97%] |
Resection only | 3 [3.85%] |
Decompression + Resection | 3 [3.85%] |
Decompression + Fixation + Resection | 3 [3.85%] |
Other | 16 [20.51%] |
Resection amount (n = 24) | |
Gross Total Resection | 11 [45.83%] |
Near-total Resection | 4 [16.67%] |
Subtotal Resection | 7 [29.17%] |
Partial Resection | 1 [4.17%] |
Marginal en bloc Resection | 1 [4.17%] |
Complications (n = 83) | |
No complications reported | 79 [95.18%] |
Complications reported | 4 [4.82%] |
Follow Up Data | Value [Percentage among Available Data] |
---|---|
Follow-up | |
Average initial follow-up time (n = 26) | 12.50 Months ± 9.83 |
Average last follow-up (n = 63) | 19.29 Months ± 24.69 |
Post Op. Treatment (n = 80) | |
Radiation therapy | 14 [17.5%] |
Chemotherapy | 16 [20.00%] |
Resection | 2 [2.5%] |
Radiotherapy and chemotherapy | 19 [23.75%] |
Other treatment | 8 [10.00%] |
No treatment | 21 [26.25%] |
Follow up symptoms (n = 26) | |
Pain | 2 [7.69%] |
Metastasis of cancer | 4 [15.38%] |
Disease Progression | 2 [7.69%] |
Follow up masses found | 5 [19.23%] |
Other symptoms | 2 [7.69%] |
No symptoms | 11 [42.31%] |
Follow-up Intervention | |
Surgical | 9 [66.67%] |
Non-surgical | 5 [33.33%] |
Symptom Resolution (n = 29) | |
Symptoms resolved | 20 [68.97%] |
Symptoms did not resolve | 9 [31.03%] |
Status (n = 71) | |
Alive | 44 [61.97%] |
Deceased | 27 [38.03%] |
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Kharbat, A.F.; Balasubramanian, K.; Sankarappan, K.; Morgan, R.D.; Hassan, K.M.; Palmisciano, P.; Pelargos, P.E.; Chukwu, M.; Bin Alamer, O.; Haider, A.S.; et al. Leiomyogenic Tumor of the Spine: A Systematic Review. Cancers 2024, 16, 748. https://doi.org/10.3390/cancers16040748
Kharbat AF, Balasubramanian K, Sankarappan K, Morgan RD, Hassan KM, Palmisciano P, Pelargos PE, Chukwu M, Bin Alamer O, Haider AS, et al. Leiomyogenic Tumor of the Spine: A Systematic Review. Cancers. 2024; 16(4):748. https://doi.org/10.3390/cancers16040748
Chicago/Turabian StyleKharbat, Abdurrahman F., Kishore Balasubramanian, Kiran Sankarappan, Ryan D. Morgan, Khawaja M. Hassan, Paolo Palmisciano, Panayiotis E. Pelargos, Michael Chukwu, Othman Bin Alamer, Ali S. Haider, and et al. 2024. "Leiomyogenic Tumor of the Spine: A Systematic Review" Cancers 16, no. 4: 748. https://doi.org/10.3390/cancers16040748
APA StyleKharbat, A. F., Balasubramanian, K., Sankarappan, K., Morgan, R. D., Hassan, K. M., Palmisciano, P., Pelargos, P. E., Chukwu, M., Bin Alamer, O., Haider, A. S., El Ahmadieh, T. Y., & Burke, J. F. (2024). Leiomyogenic Tumor of the Spine: A Systematic Review. Cancers, 16(4), 748. https://doi.org/10.3390/cancers16040748