Surface Markers and Chemokines/Cytokines of Tumor-Associated Macrophages in Osteosarcoma and Other Carcinoma Microenviornments—Contradictions and Comparisons
Abstract
:Simple Summary
Abstract
1. Introduction
2. Tumor Microenvironment (TME) of OS
M1/M2 Macrophages
3. Tumor-Associated Macrophages (TAMs)
3.1. M1/M2-Related TAM Markers
3.1.1. Iba-1
3.1.2. iNOS
3.1.3. CD80/CD86
3.1.4. CD68
3.1.5. CD163
3.1.6. CD204 (MSR1)
3.1.7. CD206 or C-Type Mannose Receptor 1 (MRC1)
3.1.8. Dendritic Cell-Specific C-Type Lectin (DC-SIGN) or CD209
3.2. Are M1/M2 TAM Markers Reliable Indicators of OS Prognosis?
4. TAM-Related Biomarkers in the TME
4.1. Chemokines
4.1.1. CCL2/Monocyte Chemoattractant Protein-1 (MCP-1)
4.1.2. CCL5 (RANTES)
4.1.3. CCL18
4.1.4. CCL22
4.1.5. CXCL1
4.1.6. CXCL5
4.1.7. CXCL6/Granulocyte Chemotaxis Protein 2 (GCP-2)
4.1.8. CXCL8 (IL-8)
4.2. Cytokines and Enzymes
4.2.1. IL-6
4.2.2. Cyclooxygenase-2 (COX-2)
4.2.3. Matrix Metalloproteinase-12 (MMP-12)
5. Origin of TAMs; Aspect from Single-Cell RNA-Sequence Analysis
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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TAM Marker | Function | Outcome | References |
---|---|---|---|
Iba-1 | Pan TAM marker | Iba-1+ TAM primary site < metastases | [34] |
iNOS | Anti-tumor | Negative correlation between expression and lung metastasis. Predictor of non-metastasis | [35] |
CD80 | Anti-tumor | CD80+ TAM primary site > metastases Decreased M1 TAM is associated with osteosarcoma metastasis | [36] |
CD86 | Anti-tumor | Anti-PD-1 treatment causes repolarization from M2 to M1 TAMs and suppresses pulmonary metastasis of osteosarcoma | [37] |
CD86 | Anti-tumor | Positive correlation between expression and prognosis Mainly expressed in M2 TAMs | [38] |
CD68 | Anti-tumor | Positive correlation between CD68+ TAM infiltration and prognosis | [39] |
CD68 | - | The amount of CD68+ TAM is the same with and without metastasis | [35] |
CD163 | Pro-tumor | Enhances T-cell suppression | [40] |
CD163 | Pro-tumor | High CD163 expression correlates with poor OS prognosis | [41] |
CD163 | Anti-tumor | Positive correlation with improved overall survival and prolonged metastasis-free survival | [42] |
CD204 | Pro-tumor | Promotes OS cell progression and metastasis | [43] |
CD68 CD163 CD204 | Pro-tumor | TAMs prepared by stimulating CD14+ PBMCs with M-CSF and 50% OS conditioned medium promote migration of OS cells | [44] |
CD204 | Anti-tumor | Positive correlation of expression with resistance to metastasis and prolonged overall survival | [45] |
iNOS CD206 | - | Macrophages activated by mifamurtide have increased levels of both iNOS and CD206, switch to an M1/M2 phenotype, inhibit cell proliferation, and induce tumor cell differentiation | [46] |
CD209 | Pro-tumor | Promotes OS progression by activating cancer stem cells | [47] |
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Tatsuno, R.; Komohara, Y.; Pan, C.; Kawasaki, T.; Enomoto, A.; Jubashi, T.; Kono, H.; Wako, M.; Ashizawa, T.; Haro, H.; et al. Surface Markers and Chemokines/Cytokines of Tumor-Associated Macrophages in Osteosarcoma and Other Carcinoma Microenviornments—Contradictions and Comparisons. Cancers 2024, 16, 2801. https://doi.org/10.3390/cancers16162801
Tatsuno R, Komohara Y, Pan C, Kawasaki T, Enomoto A, Jubashi T, Kono H, Wako M, Ashizawa T, Haro H, et al. Surface Markers and Chemokines/Cytokines of Tumor-Associated Macrophages in Osteosarcoma and Other Carcinoma Microenviornments—Contradictions and Comparisons. Cancers. 2024; 16(16):2801. https://doi.org/10.3390/cancers16162801
Chicago/Turabian StyleTatsuno, Rikito, Yoshihiro Komohara, Cheng Pan, Tomonori Kawasaki, Atsushi Enomoto, Takahiro Jubashi, Hiroyuki Kono, Masanori Wako, Tomoyuki Ashizawa, Hirotaka Haro, and et al. 2024. "Surface Markers and Chemokines/Cytokines of Tumor-Associated Macrophages in Osteosarcoma and Other Carcinoma Microenviornments—Contradictions and Comparisons" Cancers 16, no. 16: 2801. https://doi.org/10.3390/cancers16162801
APA StyleTatsuno, R., Komohara, Y., Pan, C., Kawasaki, T., Enomoto, A., Jubashi, T., Kono, H., Wako, M., Ashizawa, T., Haro, H., & Ichikawa, J. (2024). Surface Markers and Chemokines/Cytokines of Tumor-Associated Macrophages in Osteosarcoma and Other Carcinoma Microenviornments—Contradictions and Comparisons. Cancers, 16(16), 2801. https://doi.org/10.3390/cancers16162801