The Role of Peritumoral Depapillation and Its Impact on Narrow-Band Imaging in Oral Tongue Squamous Cell Carcinoma
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Treatment Protocol
2.3. Data Collection
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic | N = 76 | |
---|---|---|
Age | Median (IQR) | 70.00 (56.00, 80.00) |
Range | 22.00–100.00 | |
Gender | F | 40 (53%) |
M | 36 (47%) | |
Smoking | No | 44 (64%) |
yes | 25 (36%) | |
Alcohol | No | 54 (81%) |
yes | 13 (19%) | |
cT | 1 | 37 (49%) |
2 | 26 (34%) | |
3 | 12 (16%) | |
4a | 1 (1.3%) | |
cN | 0 | 68 (89%) |
1 | 1 (1.3%) | |
2c | 4 (5.3%) | |
2b | 2 (2.6%) | |
3b | 1 (1.3%) | |
Overall Stage | 1 | 36 (47%) |
2 | 24 (32%) | |
3 | 8 (11%) | |
4a | 6 (7.9%) | |
4b | 2 (2.6%) | |
pT | 1 | 35 (47%) |
2 | 22 (29%) | |
3 | 18 (24%) | |
pN | 0 | 33 (75%) |
1 | 6 (14%) | |
2b | 2 (4.5%) | |
2c | 1 (2.3%) | |
3b | 2 (4.5%) | |
Margins | Free | 37 (49%) |
Close | 4 (5.3%) | |
Positive | 35 (46%) | |
Grading | 1 | 13 (18%) |
2 | 51 (71%) | |
3 | 8 (11%) | |
LVI * | No | 55 (73%) |
Yes | 20 (27%) | |
PNI * | No | 44 (59%) |
Yes | 31 (41%) | |
Pathological DOI * | Median (IQR) | 6.00 (2.30, 10.00) |
Range | 0.50–40.00 | |
TILs * | No | 19 (34%) |
Yes | 37 (66%) | |
Budding | No | 38 (62%) |
Yes | 23 (38%) | |
WPOI * | 1 | 1 (5.0%) |
2 | 2 (10%) | |
3 | 8 (40%) | |
4 | 7 (35%) | |
5 | 2 (10%) | |
Depapillation | No | 36 (47%) |
Yes | 40 (53%) | |
NBI pattern | I–II | 17 (22%) |
III–IV | 59 (78%) | |
Aspect | Exophytic | 30 (39%) |
Plane | 23 (30%) | |
Ulcerated | 23 (30%) |
Variable | Overall, N = 76 | Depapillation | p-Value | |
---|---|---|---|---|
No, N = 36 | Yes, N = 40 | |||
cT | 0.90 | |||
1 | 37 (49%) | 19 (53%) | 18 (45%) | |
2 | 26 (34%) | 12 (33%) | 14 (35%) | |
3 | 12 (16%) | 5 (14%) | 7 (18%) | |
4a | 1 (1.3%) | 0 (0%) | 1 (2.5%) | |
cN | 0.053 | |||
0 | 68 (89%) | 33 (92%) | 35 (88%) | |
1 | 1 (1.3%) | 0 (0%) | 1 (2.5%) | |
2b | 4 (5.3%) | 0 (0%) | 4 (10%) | |
2c | 2 (2.6%) | 2 (5.6%) | 0 (0%) | |
3b | 1 (1.3%) | 1 (2.8%) | 0 (0%) | |
Clinical stage | 0.95 | |||
1 | 36 (47%) | 18 (50%) | 18 (45%) | |
2 | 24 (32%) | 11 (31%) | 13 (32%) | |
3 | 8 (11%) | 4 (11%) | 4 (10%) | |
4a | 6 (7.9%) | 2 (5.6%) | 4 (10%) | |
4b | 2 (2.6%) | 1 (2.8%) | 1 (2.5%) | |
pT | 0.94 | |||
1 | 35 (47%) | 17 (47%) | 18 (46%) | |
2 | 22 (29%) | 11 (31%) | 11 (28%) | |
3 | 18 (24%) | 8 (22%) | 10 (26%) | |
pN | 0.91 | |||
0 | 33 (75%) | 14 (82%) | 19 (70%) | |
1 | 6 (14%) | 2 (12%) | 4 (15%) | |
2b | 2 (4.5%) | 0 (0%) | 2 (7.4%) | |
2c | 1 (2.3%) | 0 (0%) | 1 (3.7%) | |
3b | 2 (4.5%) | 1 (5.9%) | 1 (3.7%) | |
Pathological stage | 0.59 | |||
1 | 32 (43%) | 15 (43%) | 17 (44%) | |
2 | 18 (24%) | 10 (29%) | 8 (21%) | |
3 | 19 (26%) | 9 (26%) | 10 (26%) | |
4a | 3 (4.1%) | 0 (0%) | 3 (7.7%) | |
4b | 2 (2.7%) | 1 (2.9%) | 1 (2.6%) | |
Margins | 0.49 | |||
free | 37 (49%) | 15 (42%) | 22 (55%) | |
close | 4 (5.3%) | 2 (5.6%) | 2 (5.0%) | |
positive | 35 (46%) | 19 (53%) | 16 (40%) | |
Grading | 0.49 | |||
1 | 13 (18%) | 8 (24%) | 5 (13%) | |
2 | 51 (71%) | 22 (65%) | 29 (76%) | |
3 | 8 (11%) | 4 (12%) | 4 (11%) | |
LVI * | 0.060 | |||
no | 55 (73%) | 30 (83%) | 25 (64%) | |
yes | 20 (27%) | 6 (17%) | 14 (36%) | |
PNI * | 0.022 | |||
no | 44 (59%) | 26 (72%) | 18 (46%) | |
yes | 31 (41%) | 10 (28%) | 21 (54%) | |
Pathological DOI * | 0.73 | |||
Median (IQR) | 6.00 (2.30, 10.00) | 5.50 (2.25, 9.75) | 6.00 (3.00, 10.50) | |
TILs * | 0.64 | |||
no | 19 (34%) | 10 (37%) | 9 (31%) | |
yes | 37 (66%) | 17 (63%) | 20 (69%) | |
Budding activity | 0.67 | |||
no | 38 (62%) | 17 (65%) | 21 (60%) | |
yes | 23 (38%) | 9 (35%) | 14 (40%) | |
WPOI * | 0.25 | |||
1 | 1 (5.0%) | 0 (0%) | 1 (12%) | |
2 | 2 (10%) | 2 (17%) | 0 (0%) | |
3 | 8 (40%) | 3 (25%) | 5 (62%) | |
4 | 7 (35%) | 5 (42%) | 2 (25%) | |
5 | 2 (10%) | 2 (17%) | 0 (0%) | |
NBI pattern | 0.56 | |||
I–II | 17 (22%) | 7 (19%) | 10 (25%) | |
III–IV | 59 (78%) | 29 (81%) | 30 (75%) | |
Aspect | >0.99 | |||
exophytic | 30 (39%) | 14 (39%) | 16 (40%) | |
plane | 23 (30%) | 11 (31%) | 12 (30%) | |
ulcerated | 23 (30%) | 11 (31%) | 12 (30%) |
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Iandelli, A.; Sampieri, C.; Marchi, F.; Pennacchi, A.; Carobbio, A.L.C.; Lovino Camerino, P.; Filauro, M.; Parrinello, G.; Peretti, G. The Role of Peritumoral Depapillation and Its Impact on Narrow-Band Imaging in Oral Tongue Squamous Cell Carcinoma. Cancers 2023, 15, 1196. https://doi.org/10.3390/cancers15041196
Iandelli A, Sampieri C, Marchi F, Pennacchi A, Carobbio ALC, Lovino Camerino P, Filauro M, Parrinello G, Peretti G. The Role of Peritumoral Depapillation and Its Impact on Narrow-Band Imaging in Oral Tongue Squamous Cell Carcinoma. Cancers. 2023; 15(4):1196. https://doi.org/10.3390/cancers15041196
Chicago/Turabian StyleIandelli, Andrea, Claudio Sampieri, Filippo Marchi, Alessia Pennacchi, Andrea Luigi Camillo Carobbio, Paola Lovino Camerino, Marta Filauro, Giampiero Parrinello, and Giorgio Peretti. 2023. "The Role of Peritumoral Depapillation and Its Impact on Narrow-Band Imaging in Oral Tongue Squamous Cell Carcinoma" Cancers 15, no. 4: 1196. https://doi.org/10.3390/cancers15041196