Inflammatory Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma: Transcriptional Signature and In Vitro Modeling
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Gene Expression Datasets
2.2. Data Analysis
3. Results
3.1. Transcriptional Signature of Primary MSCs from MM Patients
3.2. Expression of iMSC Signature Genes during Minimal Residual Disease
3.3. Diminished Expression of iMSC Signature Genes during In Vitro Expansion
3.4. Expression Activation of iMSC Signature Genes by Cytokine Stimulation
3.5. Expression Activation of iMSC Signature Genes by Immune Cells
3.6. Expression Activation of iMSC Signature Genes by Multiple Myeloma Cells
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Wang, L.; Yi, W.; Ma, L.; Lecea, E.; Hazlehurst, L.A.; Adjeroh, D.A.; Hu, G. Inflammatory Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma: Transcriptional Signature and In Vitro Modeling. Cancers 2023, 15, 5148. https://doi.org/10.3390/cancers15215148
Wang L, Yi W, Ma L, Lecea E, Hazlehurst LA, Adjeroh DA, Hu G. Inflammatory Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma: Transcriptional Signature and In Vitro Modeling. Cancers. 2023; 15(21):5148. https://doi.org/10.3390/cancers15215148
Chicago/Turabian StyleWang, Lei, Weijun Yi, Li Ma, Emily Lecea, Lori A. Hazlehurst, Donald A. Adjeroh, and Gangqing Hu. 2023. "Inflammatory Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma: Transcriptional Signature and In Vitro Modeling" Cancers 15, no. 21: 5148. https://doi.org/10.3390/cancers15215148