Clinical Utility of Second-Look FDG PET-CT to Stratify Incomplete Metabolic Response Post (Chemo) Radiotherapy in Oropharyngeal Squamous Cell Carcinoma
Abstract
Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Ethics Approval
2.2. Patient Selection
2.3. Staging
2.4. (Chemo)Radiotherapy
2.5. Response Assessment
2.6. Imaging Protocol
2.7. Categorisation of FDG PET-CT Response
2.8. Analysis and Statistics
3. Results
Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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n = 88 | No. | |
---|---|---|
Age | Mean | 61 |
Range | 37–78 | |
Gender | Female | 22 (25%) |
Male | 66 (75%) | |
Smoking | Current smoker | 30 (34%) |
Ex-smoker | 26 (30%) | |
Non-smoker | 11 (12%) | |
Not recorded | 21 (24%) | |
Tumour site | Tonsil | 52 (59%) |
Base of tongue | 32 (36%) | |
Soft palate | 2 (2%) | |
Vallecula | 1 (1%) | |
Posterior pharyngeal wall | 1 (1%) | |
T stage | T1 | 8 (9%) |
T2 | 31 (35%) | |
T3 | 13 (15%) | |
T4 | 36 (41%) | |
N stage | N0 | 11 (12%) |
N1 | 9 (10%) | |
N2a | 7 (8%) | |
N2b | 33 (38%) | |
N2c | 26 (30%) | |
N3 | 2 (2%) | |
HPV status | Positive | 53 (60%) |
Negative | 15 (17%) | |
Unknown | 20 (23%) | |
Radiotherapy | Radiotherapy alone | 21 (24%) |
Chemoradiotherapy | 67 (76%) |
FDG Avidity on Initial Post-Treatment PET-CT | |
---|---|
Site | Patient Number (n) |
Primary site only | 44 |
Lymph node only | 21 |
Primary site and lymph nodes | 16 |
Lung nodules | 5 |
Other | 2 |
Second-Look PET Activity | ||
---|---|---|
Active Primary on Initial Response Assessment PET-CT | Active Lymph Node on Initial Response Assessment PET-CT | |
Progression | 20 | 10 |
Stable | 20 | 14 |
Complete response | 20 | 13 |
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Billingsley, S.; Iyizoba, Z.; Frood, R.; Vaidyanathan, S.; Prestwich, R.; Scarsbrook, A. Clinical Utility of Second-Look FDG PET-CT to Stratify Incomplete Metabolic Response Post (Chemo) Radiotherapy in Oropharyngeal Squamous Cell Carcinoma. Cancers 2023, 15, 464. https://doi.org/10.3390/cancers15020464
Billingsley S, Iyizoba Z, Frood R, Vaidyanathan S, Prestwich R, Scarsbrook A. Clinical Utility of Second-Look FDG PET-CT to Stratify Incomplete Metabolic Response Post (Chemo) Radiotherapy in Oropharyngeal Squamous Cell Carcinoma. Cancers. 2023; 15(2):464. https://doi.org/10.3390/cancers15020464
Chicago/Turabian StyleBillingsley, Sarah, Zsuzsanna Iyizoba, Russell Frood, Sriram Vaidyanathan, Robin Prestwich, and Andrew Scarsbrook. 2023. "Clinical Utility of Second-Look FDG PET-CT to Stratify Incomplete Metabolic Response Post (Chemo) Radiotherapy in Oropharyngeal Squamous Cell Carcinoma" Cancers 15, no. 2: 464. https://doi.org/10.3390/cancers15020464
APA StyleBillingsley, S., Iyizoba, Z., Frood, R., Vaidyanathan, S., Prestwich, R., & Scarsbrook, A. (2023). Clinical Utility of Second-Look FDG PET-CT to Stratify Incomplete Metabolic Response Post (Chemo) Radiotherapy in Oropharyngeal Squamous Cell Carcinoma. Cancers, 15(2), 464. https://doi.org/10.3390/cancers15020464