MicroRNA-371a-3p—The Novel Serum Biomarker in Testicular Germ Cell Tumors
Abstract
:Simple Summary
Abstract
1. Introduction
2. Body
2.1. Rationale for Investigating microRNAs and First Clinical Studies
2.2. Non-Specific Small Testicular Masses
2.3. Use of miR371 in Primary Diagnosis of TGCT
2.4. Use of miR371 in Management and Follow-Up of Early Stage TGCT
2.5. Monitoring Chemotherapy with miR371
2.6. Use of miR371 for Assessing Residual Masses after Chemotherapy
2.7. The Role of miR371 in Current Guideline Recommendations
2.8. Ongoing Studies
2.9. Certified Test Kit—Practical Handling
3. Conclusions
4. Expert Opinion
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Criteria | |
---|---|
1 | The marker is exclusively produced by the malignancy. |
2 | The marker is secreted into body fluids. |
3 | The measurement is reproducible. |
4 | Marker levels in body fluids correlate with actual tumor amount. |
5 | The marker is detectable in early disease stages. |
6 | Marker levels correlate with treatment response. |
7 | The half-life of the marker is short. |
Author, Year | Number of Patients | Sensitivity (%) | Specificity (%) | AUC | PPV (%) | NPV (%) | Ref. |
---|---|---|---|---|---|---|---|
Dieckmann, 2012 | 20 | 70.8 | n/a | n/a | n/a | n/a | [26] |
Gillis, 2013 | 80 | >90 | 61 | 0.89 | n/a | n/a | [36] |
Syring, 2015 | 89 | 84.7 | 99 | 0.93 | n/a | n/a | [25] |
Dieckmann, 2017 * | 166 | 92 | 84.7 | 0.94 | n/a | n/a | [28] |
van Agthoven, 2017 | 250 | 89 | 90 | 0.95 | 94 | 79 | [27] |
Dieckmann, 2019 * | 616 | 91.8 | 96.1 | 0.97 | 97.2 | 82.7 | [34] |
Nappi, 2019 * | 110 | 96 | 100 | 0.97 | 100 | 98 | [37] |
Mørup, 2020 * | 52 | 67.5 | n/a | n/a | n/a | n/a | [38] |
Badia, 2021 | 69 | 93.1 | 100 | 0.98 | 100 | 73.3 | [39] |
Myklebust, 2021 * | 180 | 89 | 100 | n/a | 100 | 55 | [40] |
Ye, 2022 | 51 | 81.8 | 100 | 0.93 | n/a | n/a | [41] |
Sequeira, 2022 | 82 | 93.6 | 100 | 0.98 | 100 | 96 | [42] |
Author, Year | Number of Patients (Total) | Number of Patients with Relapse | Sensitivity (%) | Specificity (%) | AUC | Ref. |
---|---|---|---|---|---|---|
Terbuch, 2018 | 10 | 10 | n/a | n/a | n/a | [53] |
Dieckmann, 2019 * | 616 | 46 | 82.6 | 96.1 | 0.92 | [34] |
Lobo, 2020 | 151 | 34 | 94.1 | n/a | n/a | [48] |
Fankhauser, 2022 * | 33 | 10 | 100 | 100 | 1.0 | [54] |
Nappi 2023 | 101 | 35 | 62.8 | 100 | 0.81 | [43] |
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Nestler, T.; Schoch, J.; Belge, G.; Dieckmann, K.-P. MicroRNA-371a-3p—The Novel Serum Biomarker in Testicular Germ Cell Tumors. Cancers 2023, 15, 3944. https://doi.org/10.3390/cancers15153944
Nestler T, Schoch J, Belge G, Dieckmann K-P. MicroRNA-371a-3p—The Novel Serum Biomarker in Testicular Germ Cell Tumors. Cancers. 2023; 15(15):3944. https://doi.org/10.3390/cancers15153944
Chicago/Turabian StyleNestler, Tim, Justine Schoch, Gazanfer Belge, and Klaus-Peter Dieckmann. 2023. "MicroRNA-371a-3p—The Novel Serum Biomarker in Testicular Germ Cell Tumors" Cancers 15, no. 15: 3944. https://doi.org/10.3390/cancers15153944
APA StyleNestler, T., Schoch, J., Belge, G., & Dieckmann, K.-P. (2023). MicroRNA-371a-3p—The Novel Serum Biomarker in Testicular Germ Cell Tumors. Cancers, 15(15), 3944. https://doi.org/10.3390/cancers15153944