Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Brief Overview of Data Acquisition and Analysis
2.3. MRI Analyses
2.4. Statistical Approach
3. Results
Structural Reshaping in Patients with Brain Tumors
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Left Tumors (n = 18) | Right Tumors (n = 13) | |
---|---|---|
Handedness | ||
Right | 16 | 4 |
Left | 1 | 7 |
Ambidextrous | 1 | 2 |
Tumor type WHO | ||
Anaplastic astrocytoma | 3 | 2 |
Glioblastoma multiforme | 6 | 5 |
Metastatic | 2 | 0 |
Oligoastrocytoma | 3 | 1 |
Oligodendroglioma | 3 | 2 |
No data | 1 | 3 |
Tumor grade | ||
Low grade | 6 | 7 |
High grade | 11 | 4 |
No data | 1 | 2 |
Previous surgery | ||
Yes | 4 | 3 |
No | 12 | 9 |
No data | 2 | 1 |
Language impairment | ||
Yes | 12 | 8 |
No | 4 | 5 |
No data | 2 | 0 |
Region | Left Tumor Group | Right Tumor Group | Healthy Controls | ||||||
---|---|---|---|---|---|---|---|---|---|
T | p | Cohen’s d | T | p | Cohen’s d | T | p | Cohen’s d | |
Pars orbitalis | −1.11 | 0.282 | −0.26 | −4.50 | <0.001 * | −1.25 | 3.50 | <0.001 * | 0.42 |
Pars opercularis | 6.29 | <0.001 * | 1.48 | 0.55 | 0.590 | 0.15 | 55.24 | <0.001 * | 6.56 |
Pars triangularis | −4.33 | 0.001 * | −1.02 | −3.65 | <0.003 * | −1.01 | −36.11 | <0.001 * | −4.29 |
Mid frontal gyrus | 1.55 | 0.139 | 0.37 | 0.22 | 0.827 | 0.06 | 21.84 | <0.001 * | 2.59 |
Mid temporal pole | 4.13 | <0.001 * | 0.97 | 0.93 | 0.369 | 0.26 | 77.36 | <0.001 * | 9.18 |
Sup temporal pole | 1.88 | 0.078 | 0.44 | −1.46 | 0.171 | −0.40 | 10.45 | <0.001 * | 1.25 |
MTG | 1.13 | 0.275 | 0.27 | −4.67 | <0.001 * | −1.30 | −40.38 | <0.001 * | −4.79 |
STG | 5.40 | <0.001 * | 1.27 | −1.66 | 0.123 | −0.46 | 76.76 | <0.001 * | 9.11 |
SM | 6.51 | <0.001 * | 1.53 | −0.25 | 0.811 | 0.07 | 90.24 | <0.001 * | 10.71 |
Angular gyrus | 4.85 | <0.001 * | 1.14 | 4.89 | <0.001 * | 1.36 | 92.25 | <0.001 * | 10.95 |
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Share and Cite
Manso-Ortega, L.; De Frutos-Sagastuy, L.; Gisbert-Muñoz, S.; Salamon, N.; Qiao, J.; Walshaw, P.; Quiñones, I.; Połczyńska, M.M. Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization. Cancers 2023, 15, 3852. https://doi.org/10.3390/cancers15153852
Manso-Ortega L, De Frutos-Sagastuy L, Gisbert-Muñoz S, Salamon N, Qiao J, Walshaw P, Quiñones I, Połczyńska MM. Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization. Cancers. 2023; 15(15):3852. https://doi.org/10.3390/cancers15153852
Chicago/Turabian StyleManso-Ortega, Lucía, Laura De Frutos-Sagastuy, Sandra Gisbert-Muñoz, Noriko Salamon, Joe Qiao, Patricia Walshaw, Ileana Quiñones, and Monika M. Połczyńska. 2023. "Grey Matter Reshaping of Language-Related Regions Depends on Tumor Lateralization" Cancers 15, no. 15: 3852. https://doi.org/10.3390/cancers15153852