Disease Perception Is Correlated with Health-Related Quality of Life in Patients Suffering from Myelodysplastic Syndromes: Results of the Belgian Be-QUALMS Study
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Participants
2.2. HRQOL Measurement
2.3. Illness Perception Measurement
2.4. Demographic and Clinical Parameters
2.5. Statistical Analysis
3. Results
3.1. Patient and Disease Characteristics
3.2. Patients with MDS Suffer from Impairment in HRQoL That Remains Stable during Treatment
3.3. Disease Perception Does Not Change during the Course of Treatment
3.4. Disease Perception Is Correlated with Health-Related Quality of Life
3.5. No Significant Relation Was Found between HRQoL and Explored Interventions or Treatment Status
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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B-IPQ Item | Baseline (n = 67) | Week 4 (n = 59) | Week 12 (n = 45) | Week 24 (n = 35) | |
---|---|---|---|---|---|
How much does your illness affect your life? (“0” no effects at all—severely affects my life “10”) | Mean (sd) | 5.8 (2.8) | 5.7 (2.9) | 5.9 (2.8) | 6.1 (3.1) |
How long do you think your illness will continue? (“0” a very short time—forever “10”) | Mean (sd) | 7.8 (2.7) | 8.0 (2.3) | 7.4 (3.3) | 8.6 (2.4) |
How much control do you feel you have over your illness? (“0” absolutely no control—extreme amount of control “10”) | Mean (sd) | 4.5 (2.9) | 4.8 (2.8) | 5.4 (2.8) | 4.5 (3.1) |
How much do you think your treatment can help your illness? (“0” not at all—extremely helpful “10”) | Mean (sd) | 7.5 (1.7) | 7.8 (1.6) | 8.0 (1.5) | 7.5 (2.8) |
How much do you experience symptoms from your illness? (“0” no symptoms at all—many severe symptoms “10”) | Mean (sd) | 5.0 (2.8) | 4.1 (2.8) | 4.2 (2.7) | 3.9 (2.6) |
How concerned are you about your illness? (“0” not at all concerned—extremely concerned “10”) | Mean (sd) | 7.1 (2.4) | 6.6 (2.8) | 6.7 (2.6) | 6.9 (2.9) |
How well do you feel you understand your illness? (“0” don’t understand at all—understand very clearly “10”) | Mean (sd) | 6.4 (2.5) | 6.6 (2.9) | 6.2 (2.6) | 5.7 (3.2) |
How much does your illness affect you emotionally (“0” not at all affected emotionally—extremely affected emotionally “10”) | Mean (sd) | 5.4 (2.4) | 5.3 (3.1) | 5.4 (3.1) | 5.3 (3.0) |
QUALMS Final | QUALMS Emotional | QUALMS Benefit | QUALMS Burden | |||||
---|---|---|---|---|---|---|---|---|
B-IPQ1 (life-affecting) | r = −0.39 (p = 0.001) | ** | r = −0.27 (p = 0.026) | * | r = 0.28 (p = 0.022) | * | r = −0.48 (p < 0.001) | *** |
B-IPQ2 (duration) | r = −0.12 (p = 0.31) | r = −0.08 (p = 0.50) | r = 0.29 (p = 0.018) | * | r = −0.18 (p = 0.14) | |||
B-IPQ3 (control) | r = 0.39 (p = 0.001) | ** | r = 0.36 (p = 0.003) | ** | r = −0.04 (p = 0.74) | r = 0.35 (p = 0.004) | ** | |
B-IPQ4 (treatment) | r = 0.21 (p = 0.082) | ˙ | r = 0.16 (p = 0.202) | r = 0.16 (p = 0.19) | r = 0.14 (p = 0.25) | |||
B-IPQ5 (symptoms) | r = −0.37 (p = 0.002) | ** | r = −0.27 (p = 0.028) | * | r = 0.14 (p = 0.25) | r = −0.43 (p < 0.001) | *** | |
B-IPQ6 (concerns) | r = −0.44 (p < 0.001) | *** | r = −0.50 (p < 0.001) | *** | r = 0.17 (p = 0.17) | r = −0.30 (p = 0.014) | * | |
B-IPQ7 (understanding) | r = −0.04 (p = 0.77) | r = −0.15 (p = 0.21) | r = 0.38 (p = 0.002) | ** | r = −0.07 (p = 0.55) | |||
B-IPQ8 (emotional) | r = −0.48 (p < 0.001) | *** | r = −0.39 (p = 0.001) | ** | r = 0.14 (p = 0.27) | r = −0.42 (p < 0.001) | *** |
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Heyrman, B.; Meers, S.; De Becker, A.; Wouters, K.; Van Hoof, A.; Van De Velde, A.; Graux, C.; Mazure, D.; Selleslag, D.; Maes, H.; et al. Disease Perception Is Correlated with Health-Related Quality of Life in Patients Suffering from Myelodysplastic Syndromes: Results of the Belgian Be-QUALMS Study. Cancers 2023, 15, 3296. https://doi.org/10.3390/cancers15133296
Heyrman B, Meers S, De Becker A, Wouters K, Van Hoof A, Van De Velde A, Graux C, Mazure D, Selleslag D, Maes H, et al. Disease Perception Is Correlated with Health-Related Quality of Life in Patients Suffering from Myelodysplastic Syndromes: Results of the Belgian Be-QUALMS Study. Cancers. 2023; 15(13):3296. https://doi.org/10.3390/cancers15133296
Chicago/Turabian StyleHeyrman, Bert, Stef Meers, Ann De Becker, Kristien Wouters, Achiel Van Hoof, Ann Van De Velde, Carlos Graux, Dominiek Mazure, Dominik Selleslag, Helena Maes, and et al. 2023. "Disease Perception Is Correlated with Health-Related Quality of Life in Patients Suffering from Myelodysplastic Syndromes: Results of the Belgian Be-QUALMS Study" Cancers 15, no. 13: 3296. https://doi.org/10.3390/cancers15133296
APA StyleHeyrman, B., Meers, S., De Becker, A., Wouters, K., Van Hoof, A., Van De Velde, A., Graux, C., Mazure, D., Selleslag, D., Maes, H., Lemmens, J., Beckers, M., Breems, D., Sid, S., Berneman, Z., & Anguille, S. (2023). Disease Perception Is Correlated with Health-Related Quality of Life in Patients Suffering from Myelodysplastic Syndromes: Results of the Belgian Be-QUALMS Study. Cancers, 15(13), 3296. https://doi.org/10.3390/cancers15133296