Difference in Efficacy and Safety of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy Containing 4-1BB and CD28 Co-Stimulatory Domains for B-Cell Acute Lymphoblastic Leukemia
Abstract
Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Search Strategy and Selection Criteria
2.2. Data Extraction
2.3. Risk of Bias Assessment
2.4. Modeling Analysis of Overall and Progression-Free Survival
2.5. Meta-Analysis for the Secondary and Safety Outcomes
2.6. Correlation between ORR, MRD-Negative CR, PFS, and OS
2.7. Software and Statistical Analysis
3. Results
3.1. Characteristics of the Included Studies
3.2. Model Establishment and Evaluation
3.3. Typical Overall and Progression-Free Survival Simulation
3.4. Meta-Analysis for Secondary and Safety Outcomes
3.5. Correlation between ORR, MRD-Negative CR, PFS, and OS
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Parameter (Co-Stimulatory Domain) | OS Model | PFS Model | ||||||
---|---|---|---|---|---|---|---|---|
Final Model | Bootstrap (959/1000 *) | Final Model | Bootstrap (919/1000 *) | |||||
Value (RSE%) | Shrinkage (%) | Median | 95% CI | Value (RSE%) | Shrinkage (%) | Median | 95% CI | |
Survival parameters | ||||||||
(4-1BB) | 1.52 (7.8) | 1.51 | 1.29–1.77 | 1.67 (8.9) | 1.67 | 1.40–2.00 | ||
(CD28) | 1.42 (10.5) | 1.44 | 1.13–1.74 | 2.03 (24.4) | 2.17 | 1.12–5.00 | ||
(4-1BB) | 2.83 (5.1) | 2.80 | 2.54–3.12 | 2.13 (12.5) | 2.16 | 1.63–2.79 | ||
(CD28) | 2.23 (11.1) | 2.25 | 1.45–2.87 | 1.56 (20.9) | 1.59 | 0.90–4.00 | ||
θMorphological relapse | 1.22 (43.4) | 1.30 | 0.44–2.61 | 1.78 (21.6) | 1.80 | 0.56–2.87 | ||
Variability parameters | ||||||||
η () | 0.329 (13.6) | 9.6 | 0.312 | 0.224–0.404 | 0.330 (14.4) | 10.7 | 0.301 | 0.162–0.423 |
η () | 0.240 (13.7) | 3.0 | 0.240 | 0.170–0.327 | 0.459 (15.0) | 2.4 | 0.432 | 0.223–0.560 |
ε | 0.623 (9.3) | 6.7 | 0.616 | 0.501–0.725 | 0.727 (10.0) | 6.9 | 0.729 | 0.574–0.858 |
4-1BB | CD28 | |
---|---|---|
Overall survival | ||
Median OS, month | 15.0 (11.0–20.0) | 8.5 (5.0–14.0) |
1-year OS rate, % | 56.6 (47.1–67.6) | 38.6 (24.0–56.6) |
2-year OS rate, % | 34.8 (26.6–43.9) | 18.3 (8.7–31.6) |
5-year OS rate, % | 12.5 (7.9–18.3) | 4.2 (1.1–10.2) |
Progression-free survival | ||
Median PFS, month | 7.0 (4.0–11.5) | 3.0 (1.5–7.0) |
1-year PFS rate, % | 33.8 (20.7–49.6) | 20.8 (9.0–34.8) |
2-year PFS rate, % | 17.3 (8.8–29.0) | 10.5 (2.1–19.8) |
5-year PFS rate, % | 5.0 (1.7–10.9) | 3.4 (0.1–9.4) |
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Wu, L.; Chen, J.; Cai, R.; Wang, X.; Liu, Y.; Zheng, Q.; Li, L. Difference in Efficacy and Safety of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy Containing 4-1BB and CD28 Co-Stimulatory Domains for B-Cell Acute Lymphoblastic Leukemia. Cancers 2023, 15, 2767. https://doi.org/10.3390/cancers15102767
Wu L, Chen J, Cai R, Wang X, Liu Y, Zheng Q, Li L. Difference in Efficacy and Safety of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy Containing 4-1BB and CD28 Co-Stimulatory Domains for B-Cell Acute Lymphoblastic Leukemia. Cancers. 2023; 15(10):2767. https://doi.org/10.3390/cancers15102767
Chicago/Turabian StyleWu, Lijuan, Junchao Chen, Ruifen Cai, Xinrui Wang, Yixiao Liu, Qingshan Zheng, and Lujin Li. 2023. "Difference in Efficacy and Safety of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy Containing 4-1BB and CD28 Co-Stimulatory Domains for B-Cell Acute Lymphoblastic Leukemia" Cancers 15, no. 10: 2767. https://doi.org/10.3390/cancers15102767
APA StyleWu, L., Chen, J., Cai, R., Wang, X., Liu, Y., Zheng, Q., & Li, L. (2023). Difference in Efficacy and Safety of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy Containing 4-1BB and CD28 Co-Stimulatory Domains for B-Cell Acute Lymphoblastic Leukemia. Cancers, 15(10), 2767. https://doi.org/10.3390/cancers15102767