Association of Physical Activity Intensity with All-Cause Mortality in Cancer Survivors: A National Prospective Cohort Study
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Population
2.2. Study Outcome
2.3. Study Exposure
2.4. Study Covariates
2.5. Statistical Analysis
3. Results
3.1. Population Characteristics
3.2. The Relationship between PA and Cancer Survivors’ Mortality
3.3. Subgroup Analyses
3.4. Sensitivity Analyses
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Leisure Time PA Level, Minutes/Week | |||||||
---|---|---|---|---|---|---|---|
0 | 10 min–1 h | 1–2.5 h | 2.5–5 h | 5–7.5 h | 7.5–13.3 h | 13.3–24 h | |
Sex, % | |||||||
Female | 5718 (64.71%) | 764 (67.37%) | 1959 (65.52%) | 1661 (60.84%) | 1076 (60.35%) | 869 (53.74%) | 493 (49.45%) |
Male | 3119 (35.29%) | 370 (32.63%) | 1031 (34.48%) | 1069 (39.16%) | 707 (39.65%) | 748 (46.26%) | 504 (50.55%) |
Age, years, % | |||||||
<40 | 690 (7.81%) | 111 (9.79%) | 281 (9.40%) | 278 (10.18%) | 240 (13.46%) | 259 (16.02%) | 158 (15.85%) |
40–59 | 2227 (25.20%) | 388 (34.22%) | 928 (31.04%) | 928 (33.99%) | 629 (35.28%) | 620 (38.34%) | 328 (32.90%) |
≥60 | 5920 (66.99%) | 635 (56.00%) | 1781 (59.57%) | 1524 (55.82%) | 914 (51.26%) | 738 (45.64%) | 511 (51.25%) |
Body mass index, kg/m2, % | |||||||
<18.5 | 267 (3.12%) | 23 (2.10%) | 68 (2.33%) | 41 (1.53%) | 25 (1.42%) | 22 (1.38%) | 16 (1.63%) |
18.5–24.9 | 2997 (35.00%) | 349 (31.84%) | 1083 (37.04%) | 1078 (40.34%) | 744 (42.27%) | 671 (42.15%) | 408 (41.68%) |
25–29.9 | 2983 (34.83%) | 385 (35.13%) | 1068 (36.53%) | 1031 (38.59%) | 650 (36.93%) | 621 (39.01%) | 362 (36.98%) |
≥30 | 2317 (27.06%) | 339 (30.93%) | 705 (24.11%) | 522 (19.54%) | 341 (19.38%) | 278 (17.46%) | 193 (19.71%) |
Race/ethnicity, % | |||||||
White | 7645 (86.51%) | 979 (86.33%) | 2706 (90.50%) | 2503 (91.68%) | 1640 (91.98%) | 1495 (92.46%) | 900 (90.27%) |
Black | 957 (10.83%) | 118 (10.41%) | 201 (6.72%) | 168 (6.15%) | 87 (4.88%) | 79 (4.89%) | 60 (6.02%) |
Other | 235 (2.66%) | 37 (3.26%) | 83 (2.78%) | 59 (2.16%) | 56 (3.14%) | 43 (2.66%) | 37 (3.71%) |
Marital status, % | |||||||
Married/Living with partner | 4074 (46.18%) | 582 (51.41%) | 1592 (53.30%) | 1539 (56.46%) | 1028 (57.69%) | 975 (60.30%) | 572 (57.49%) |
Divorced/separated/widowed | 4062 (46.04%) | 453 (40.02%) | 1152 (38.57%) | 923 (33.86%) | 578 (32.44%) | 472 (29.19%) | 324 (32.56%) |
Never married | 686 (7.78%) | 97 (8.57%) | 243 (8.14%) | 264 (9.68%) | 176 (9.88%) | 170 (10.51%) | 99 (9.95%) |
Alcohol drinking, % | |||||||
Lifetime abstainer | 2630 (37.20%) | 213 (26.30%) | 550 (25.87%) | 427 (22.71%) | 232 (19.46%) | 174 (16.84%) | 145 (21.71%) |
Former drinker | 1864 (26.37%) | 206 (25.43%) | 512 (24.08%) | 432 (22.98%) | 252 (21.14%) | 194 (18.78%) | 150 (22.46%) |
Current drinker | 2575 (36.43%) | 391 (48.27%) | 1064 (50.05%) | 1021 (54.31%) | 708 (59.40%) | 665 (64.38%) | 373 (55.84%) |
Smoking status, % | |||||||
Never | 1806 (20.50%) | 191 (16.84%) | 464 (15.54%) | 357 (13.09%) | 269 (15.10%) | 211 (13.07%) | 162 (16.27%) |
Former | 1750 (19.86%) | 209 (18.43%) | 607 (20.34%) | 592 (21.71%) | 368 (20.65%) | 358 (22.18%) | 214 (21.49%) |
Current | 3510 (39.84%) | 472 (41.62%) | 1241 (41.57%) | 1133 (41.55%) | 748 (41.98%) | 667 (41.33%) | 399 (40.06%) |
Smoker, current status unknown | 1745 (19.80%) | 262 (23.10%) | 673 (22.55%) | 645 (23.65%) | 397 (22.28%) | 378 (23.42%) | 221 (22.19%) |
Diabetes, % | |||||||
No | 7228 (81.83%) | 969 (85.45%) | 2578 (86.28%) | 2377 (87.07%) | 1574 (88.28%) | 1468 (90.79%) | 904 (90.67%) |
Yes | 1462 (16.55%) | 150 (13.23%) | 354 (11.85%) | 300 (10.99%) | 176 (9.87%) | 130 (8.04%) | 77 (7.72%) |
Borderline | 143 (1.62%) | 15 (1.32%) | 56 (1.87%) | 53 (1.94%) | 33 (1.85%) | 19 (1.18%) | 16 (1.60%) |
Hypertension, % | |||||||
No | 4178 (47.32%) | 572 (50.49%) | 1610 (53.90%) | 1579 (57.86%) | 1064 (59.74%) | 1060 (65.55%) | 606 (60.84%) |
Yes | 4652 (52.68%) | 561 (49.51%) | 1377 (46.10%) | 1150 (42.14%) | 717 (40.26%) | 557 (34.45%) | 390 (39.16%) |
Coronary heart disease, % | |||||||
No | 7763 (88.10%) | 1026 (90.72%) | 2711 (90.97%) | 2485 (91.16%) | 1640 (92.24%) | 1501 (92.88%) | 916 (92.06%) |
Yes | 1049 (11.90%) | 105 (9.28%) | 269 (9.03%) | 241 (8.84%) | 138 (7.76%) | 115 (7.12%) | 79 (7.94%) |
Angina, % | |||||||
No | 8145 (92.41%) | 1070 (94.52%) | 2793 (93.69%) | 2590 (94.98%) | 1691 (95.05%) | 1543 (95.48%) | 959 (96.29%) |
Yes | 669 (7.59%) | 62 (5.48%) | 188 (6.31%) | 137 (5.02%) | 88 (4.95%) | 73 (4.52%) | 37 (3.71%) |
Myocardial infarction, % | |||||||
No | 7879 (89.34%) | 1048 (92.50%) | 2778 (93.07%) | 2544 (93.29%) | 1688 (94.78%) | 1523 (94.25%) | 945 (94.78%) |
Yes | 940 (10.66%) | 85 (7.50%) | 207 (6.93%) | 183 (6.71%) | 93 (5.22%) | 93 (5.75%) | 52 (5.22%) |
Stroke, % | |||||||
No | 8036 (91.12%) | 1071 (94.69%) | 2853 (95.42%) | 2621 (96.08%) | 1721 (96.74%) | 1580 (97.71%) | 957 (95.99%) |
Yes | 783 (8.88%) | 60 (5.31%) | 137 (4.58%) | 107 (3.92%) | 58 (3.26%) | 37 (2.29%) | 40 (4.01%) |
Asthma, % | |||||||
No | 7618 (86.31%) | 981 (86.74%) | 2623 (87.84%) | 2409 (88.34%) | 1578 (88.65%) | 1425 (88.13%) | 889 (89.17%) |
Yes | 1208 (13.69%) | 150 (13.26%) | 363 (12.16%) | 318 (11.66%) | 202 (11.35%) | 192 (11.87%) | 108 (10.83%) |
Non-Adjusted | Adjust I | Adjust II | |
---|---|---|---|
All-cause mortality | |||
PA(Continuous) | 0.92 (0.91, 0.92) < 0.0001 | 0.94 (0.93, 0.95) < 0.0001 | 0.95 (0.95, 0.96) < 0.0001 |
PA level | |||
0 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
10 min–1 h | 0.60 (0.54, 0.67) < 0.0001 | 0.71 (0.64, 0.79) < 0.0001 | 0.75 (0.67, 0.85) < 0.0001 |
1–2.5 h | 0.60 (0.56, 0.64) < 0.0001 | 0.67 (0.63, 0.72) < 0.0001 | 0.72 (0.67, 0.78) < 0.0001 |
2.5–5 h | 0.48 (0.45, 0.52) < 0.0001 | 0.58 (0.54, 0.63) < 0.0001 | 0.66 (0.60, 0.72) < 0.0001 |
5–7.5 h | 0.43 (0.39, 0.48) < 0.0001 | 0.55 (0.50, 0.61) < 0.0001 | 0.63 (0.56, 0.70) < 0.0001 |
7.5–13.3 h | 0.35 (0.32, 0.40) < 0.0001 | 0.48 (0.42, 0.53) < 0.0001 | 0.53 (0.47, 0.61) < 0.0001 |
13.3–24 h | 0.39 (0.34, 0.45) < 0.0001 | 0.50 (0.43, 0.57) < 0.0001 | 0.57 (0.49, 0.66) < 0.0001 |
p for trend | <0.001 | <0.001 | <0.001 |
Cancer mortality | |||
PA(Continuous) | 0.89 (0.83, 0.96) 0.0027 | 0.91 (0.85, 0.98) 0.0114 | 0.90 (0.83, 0.98) 0.0115 |
PA level | |||
0 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
10 min–1 h | 0.64 (0.26, 1.58) 0.3328 | 0.70 (0.28, 1.73) 0.4362 | 0.86 (0.35, 2.15) 0.7535 |
1–2.5 h | 0.25 (0.11, 0.58) 0.0011 | 0.28 (0.12, 0.64) 0.0025 | 0.23 (0.08, 0.64) 0.0046 |
2.5–5 h | 0.48 (0.24, 0.96) 0.0371 | 0.55 (0.27, 1.10) 0.0884 | 0.61 (0.29, 1.30) 0.2007 |
5–7.5 h | 0.31 (0.11, 0.84) 0.0212 | 0.36 (0.13, 0.98) 0.0461 | 0.42 (0.15, 1.17) 0.0986 |
7.5–13.3 h | 0.29 (0.09, 0.93) 0.0365 | 0.34 (0.11, 1.09) 0.0701 | 0.29 (0.07, 1.20) 0.0872 |
13.3–24 h | 0.45 (0.14, 1.43) 0.1771 | 0.48 (0.15, 1.55) 0.2208 | 0.37 (0.09, 1.51) 0.1646 |
p for trend | 0.003 | 0.011 | 0.011 |
Cardiovascular disease mortality | |||
PA(Continuous) | 0.96 (0.93, 0.99) 0.0084 | 0.96 (0.93, 0.99) 0.0083 | 0.95 (0.91, 0.98) 0.0052 |
PA level | |||
0 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
10 min–1 h | 1.24 (0.79, 1.92) 0.3478 | 1.32 (0.85, 2.05) 0.2222 | 1.39 (0.88, 2.20) 0.1632 |
1–2.5 h | 0.83 (0.60, 1.14) 0.2530 | 0.88 (0.63, 1.22) 0.4368 | 0.84 (0.59, 1.22) 0.3674 |
2.5–5 h | 0.80 (0.55, 1.15) 0.2232 | 0.84 (0.58, 1.22) 0.3643 | 0.69 (0.45, 1.06) 0.0906 |
5–7.5 h | 0.89 (0.59, 1.34) 0.5828 | 0.90 (0.60, 1.36) 0.6229 | 0.87 (0.55, 1.37) 0.5429 |
7.5–13.3 h | 0.68 (0.41, 1.14) 0.1412 | 0.71 (0.43, 1.19) 0.1979 | 0.60 (0.32, 1.11) 0.1027 |
13.3–24 h | 0.46 (0.22, 0.98) 0.0447 | 0.40 (0.18, 0.91) 0.0294 | 0.40 (0.16, 0.99) 0.0470 |
p for trend | 0.008 | 0.003 | 0.005 |
Inflection Point | Group | HR (95% CI) | p Value | p for Log Likelihood Ratio Test | |
---|---|---|---|---|---|
Physical activity | 1 h/week | ≤1 | 0.70 (0.66, 0.75) | <0.001 | <0.001 |
>1 | 0.98 (0.97, 0.99) | <0.001 |
Variable | Participants, No. | 0 | 10 min–1 h | 1–2.5 h | 2.5–5 h | 5–7.5 h | 7.5–13.3 h | 13.3–24 h | p Value for Interaction |
---|---|---|---|---|---|---|---|---|---|
Age, y | 0.7287 | ||||||||
<40 | 2017 | 1 [Reference] | 0.77 (0.33, 1.83) 0.5598 | 0.78 (0.44, 1.40) 0.4113 | 0.40 (0.19, 0.84) 0.0155 | 0.64 (0.32, 1.28) 0.2076 | 0.61 (0.31, 1.21) 0.1573 | 0.51 (0.20, 1.29) 0.1561 | |
40–59 | 6048 | 1 [Reference] | 0.88 (0.65, 1.19) 0.4071 | 0.70 (0.56, 0.89) 0.0029 | 0.57 (0.44, 0.73) < 0.0001 | 0.66 (0.50, 0.88) 0.0041 | 0.53 (0.38, 0.73) < 0.0001 | 0.45 (0.29, 0.68) 0.0002 | |
≥60 | 12023 | 1 [Reference] | 0.70 (0.61, 0.80) < 0.0001 | 0.68 (0.62, 0.74) < 0.0001 | 0.59 (0.54, 0.65) < 0.0001 | 0.56 (0.49, 0.63) < 0.0001 | 0.44 (0.38, 0.51) < 0.0001 | 0.50 (0.42, 0.59) < 0.0001 | |
Sex | 0.603 | ||||||||
Female | 12540 | 1 [Reference] | 0.77 (0.66, 0.91) 0.0016 | 0.70 (0.63, 0.78) < 0.0001 | 0.66 (0.58, 0.75) < 0.0001 | 0.64 (0.55, 0.75) < 0.0001 | 0.52 (0.42, 0.64) < 0.0001 | 0.49 (0.38, 0.64) < 0.0001 | |
Male | 7548 | 1 [Reference] | 0.72 (0.60, 0.87) 0.0008 | 0.76 (0.67, 0.86) < 0.0001 | 0.65 (0.57, 0.74) < 0.0001 | 0.62 (0.53, 0.73) < 0.0001 | 0.54 (0.45, 0.64) < 0.0001 | 0.62 (0.51, 0.74) < 0.0001 | |
BMI, Kg/m2 | 0.1238 | ||||||||
<18.5 | 462 | 1 [Reference] | 0.76 (0.32, 1.80) 0.5259 | 0.69 (0.44, 1.07) 0.0951 | 0.42 (0.23, 0.79) 0.0068 | 0.33 (0.14, 0.80) 0.0140 | 0.44 (0.13, 1.47) 0.1815 | 0.53 (0.16, 1.71) 0.2851 | |
18.5–24.9 | 7330 | 1 [Reference] | 0.76 (0.32, 1.80) 0.5259 | 0.69 (0.44, 1.07) 0.0951 | 0.42 (0.23, 0.79) 0.0068 | 0.33 (0.14, 0.80) 0.0140 | 0.44 (0.13, 1.47) 0.1815 | 0.53 (0.16, 1.71) 0.2851 | |
25–29.9 | 7100 | 1 [Reference] | 0.73 (0.59, 0.90) 0.0034 | 0.78 (0.68, 0.89) 0.0002 | 0.71 (0.62, 0.82) < 0.0001 | 0.74 (0.62, 0.89) 0.0012 | 0.62 (0.50, 0.75) < 0.0001 | 0.57 (0.44, 0.74) < 0.0001 | |
≥30 | 4695 | 1 [Reference] | 0.82 (0.64, 1.04) 0.0937 | 0.63 (0.53, 0.77) < 0.0001 | 0.65 (0.52, 0.80) < 0.0001 | 0.50 (0.38, 0.67) < 0.0001 | 0.56 (0.41, 0.77) 0.0004 | 0.82 (0.60, 1.12) 0.2066 | |
Race/ethnicity | 0.5269 | ||||||||
White | 17868 | 1 [Reference] | 0.75 (0.66, 0.86) < 0.0001 | 0.72 (0.66, 0.78) < 0.0001 | 0.67 (0.61, 0.73) < 0.0001 | 0.65 (0.58, 0.73) < 0.0001 | 0.54 (0.47, 0.62) < 0.0001 | 0.57 (0.49, 0.67) < 0.0001 | |
Black | 1670 | 1 [Reference] | 0.69 (0.46, 1.02) 0.0640 | 0.72 (0.54, 0.96) 0.0229 | 0.54 (0.38, 0.77) 0.0006 | 0.55 (0.35, 0.86) 0.0093 | 0.59 (0.33, 1.02) 0.0606 | 0.80 (0.47, 1.38) 0.4282 | |
Other | 550 | 1 [Reference] | 1.12 (0.59, 2.12) 0.7376 | 0.61 (0.30, 1.27) 0.1906 | 0.80 (0.42, 1.53) 0.5025 | 0.37 (0.15, 0.90) 0.0287 | 0.32 (0.11, 0.93) 0.0360 | 0.16 (0.02, 1.15) 0.0678 | |
Marital status | 0.907 | ||||||||
Married/Living with partner | 10362 | 1 [Reference] | 0.75 (0.62, 0.90) 0.0018 | 0.69 (0.61, 0.78) < 0.0001 | 0.67 (0.59, 0.76) < 0.0001 | 0.62 (0.53, 0.73) < 0.0001 | 0.54 (0.45, 0.65) < 0.0001 | 0.55 (0.44, 0.68) < 0.0001 | |
Divorced/separated/widowed | 7964 | 1 [Reference] | 0.73 (0.61, 0.87) 0.0004 | 0.74 (0.67, 0.83) < 0.0001 | 0.64 (0.56, 0.73) < 0.0001 | 0.66 (0.56, 0.78) < 0.0001 | 0.51 (0.41, 0.63) < 0.0001 | 0.58 (0.46, 0.73) < 0.0001 | |
Never married | 1735 | 1 [Reference] | 1.11 (0.69, 1.77) 0.6709 | 0.72 (0.51, 1.01) 0.0605 | 0.67 (0.45, 0.98) 0.0403 | 0.52 (0.32, 0.85) 0.0082 | 0.68 (0.42, 1.11) 0.1247 | 0.62 (0.34, 1.13) 0.1195 | |
Alcohol drinking | 0.941 | ||||||||
Lifetime abstainer | 4371 | 1 [Reference] | 0.80 (0.64, 1.00) 0.0540 | 0.70 (0.60, 0.82) < 0.0001 | 0.68 (0.57, 0.82) < 0.0001 | 0.60 (0.47, 0.76) < 0.0001 | 0.52 (0.38, 0.71) < 0.0001 | 0.61 (0.45, 0.84) 0.0025 | |
Former drinker | 3610 | 1 [Reference] | 0.78 (0.63, 0.96) 0.0218 | 0.69 (0.60, 0.80) < 0.0001 | 0.60 (0.51, 0.71) < 0.0001 | 0.61 (0.49, 0.75) < 0.0001 | 0.48 (0.36, 0.64) < 0.0001 | 0.62 (0.47, 0.82) 0.0007 | |
Current drinker | 6797 | 1 [Reference] | 0.71 (0.59, 0.86) 0.0006 | 0.75 (0.66, 0.85) < 0.0001 | 0.69 (0.61, 0.79) < 0.0001 | 0.67 (0.57, 0.78) < 0.0001 | 0.57 (0.48, 0.68) < 0.0001 | 0.54 (0.43, 0.67) < 0.0001 | |
Smoking status | 0.032 | ||||||||
Never | 3460 | 1 [Reference] | 0.99 (0.74, 1.34) 0.9635 | 0.74 (0.60, 0.92) 0.0054 | 0.54 (0.41, 0.71) < 0.0001 | 0.78 (0.60, 1.03) 0.0807 | 0.80 (0.59, 1.09) 0.1512 | 0.60 (0.41, 0.88) 0.0079 | |
Former | 4089 | 1 [Reference] | 0.74 (0.60, 0.92) 0.0066 | 0.73 (0.64, 0.83) < 0.0001 | 0.69 (0.60, 0.80) < 0.0001 | 0.70 (0.59, 0.85) 0.0002 | 0.54 (0.44, 0.66) < 0.0001 | 0.60 (0.48, 0.76) < 0.0001 | |
Current | 8170 | 1 [Reference] | 0.64 (0.52, 0.77) < 0.0001 | 0.68 (0.60, 0.77) < 0.0001 | 0.64 (0.56, 0.74) < 0.0001 | 0.54 (0.45, 0.65) < 0.0001 | 0.44 (0.35, 0.55) < 0.0001 | 0.50 (0.39, 0.65) < 0.0001 | |
Diabetes | 0.9089 | ||||||||
No | 17098 | 1 [Reference] | 0.74 (0.65, 0.85) < 0.0001 | 0.72 (0.66, 0.79) < 0.0001 | 0.65 (0.59, 0.72) < 0.0001 | 0.63 (0.55, 0.71) < 0.0001 | 0.50 (0.43, 0.58) < 0.0001 | 0.55 (0.47, 0.65) < 0.0001 | |
Yes | 2649 | 1 [Reference] | 0.80 (0.60, 1.05) 0.1086 | 0.68 (0.56, 0.83) 0.0002 | 0.67 (0.54, 0.82) 0.0002 | 0.67 (0.51, 0.88) 0.0041 | 0.70 (0.52, 0.95) 0.0215 | 0.77 (0.51, 1.15) 0.1979 | |
Hypertension | 0.0435 | ||||||||
No | 10669 | 1 [Reference] | 0.69 (0.57, 0.84) 0.0002 | 0.77 (0.68, 0.86) < 0.0001 | 0.65 (0.57, 0.74) < 0.0001 | 0.59 (0.50, 0.70) < 0.0001 | 0.47 (0.39, 0.57) < 0.0001 | 0.49 (0.39, 0.62) < 0.0001 | |
Yes | 9404 | 1 [Reference] | 0.80 (0.68, 0.93) 0.0046 | 0.68 (0.61, 0.76) < 0.0001 | 0.66 (0.58, 0.74) < 0.0001 | 0.66 (0.57, 0.77) < 0.0001 | 0.60 (0.50, 0.72) < 0.0001 | 0.64 (0.53, 0.79) < 0.0001 | |
Coronary heart disease | 0.0428 | ||||||||
No | 18042 | 1 [Reference] | 0.75 (0.66, 0.86) < 0.0001 | 0.73 (0.67, 0.79) < 0.0001 | 0.63 (0.57, 0.69) < 0.0001 | 0.61 (0.54, 0.69) < 0.0001 | 0.53 (0.46, 0.61) < 0.0001 | 0.53 (0.44, 0.62) < 0.0001 | |
Yes | 1996 | 1 [Reference] | 0.76 (0.55, 1.05) 0.0944 | 0.70 (0.56, 0.86) 0.0007 | 0.81 (0.65, 1.01) 0.0560 | 0.77 (0.58, 1.02) 0.0661 | 0.53 (0.37, 0.75) 0.0003 | 0.88 (0.62, 1.25) 0.4626 | |
Angina | 0.2168 | ||||||||
No | 18791 | 1 [Reference] | 0.76 (0.67, 0.86) < 0.0001 | 0.72 (0.66, 0.78) < 0.0001 | 0.64 (0.58, 0.70) < 0.0001 | 0.60 (0.54, 0.68) < 0.0001 | 0.54 (0.47, 0.62) < 0.0001 | 0.57 (0.49, 0.67) < 0.0001 | |
Yes | 1254 | 1 [Reference] | 0.67 (0.45, 1.01) 0.0585 | 0.72 (0.57, 0.92) 0.0081 | 0.80 (0.61, 1.04) 0.0992 | 0.93 (0.66, 1.30) 0.6648 | 0.50 (0.33, 0.76) 0.0013 | 0.51 (0.28, 0.92) 0.0258 | |
Myocardial infarction | 0.3738 | ||||||||
No | 18405 | 1 [Reference] | 0.77 (0.67, 0.87) < 0.0001 | 0.72 (0.66, 0.78) < 0.0001 | 0.63 (0.58, 0.70) < 0.0001 | 0.62 (0.55, 0.70) < 0.0001 | 0.54 (0.47, 0.61) < 0.0001 | 0.57 (0.48, 0.67) < 0.0001 | |
Yes | 1653 | 1 [Reference] | 0.62 (0.44, 0.88) 0.0066 | 0.69 (0.55, 0.86) 0.0012 | 0.80 (0.63, 1.01) 0.0571 | 0.66 (0.47, 0.92) 0.0149 | 0.49 (0.32, 0.73) 0.0005 | 0.57 (0.35, 0.92) 0.0218 | |
Stroke | 0.0876 | ||||||||
No | 18839 | 1 [Reference] | 0.79 (0.70, 0.90) 0.0003 | 0.73 (0.67, 0.79) < 0.0001 | 0.66 (0.60, 0.72) < 0.0001 | 0.63 (0.56, 0.70) < 0.0001 | 0.53 (0.46, 0.61) < 0.0001 | 0.55 (0.47, 0.65) < 0.0001 | |
Yes | 1222 | 1 [Reference] | 0.43 (0.27, 0.69) 0.0004 | 0.66 (0.51, 0.86) 0.0018 | 0.66 (0.48, 0.91) 0.0102 | 0.62 (0.41, 0.95) 0.0264 | 0.50 (0.27, 0.92) 0.0249 | 0.95 (0.56, 1.61) 0.8575 | |
Asthma | 0.7195 | ||||||||
No | 17523 | 1 [Reference] | 0.76 (0.67, 0.87) < 0.0001 | 0.72 (0.66, 0.79) < 0.0001 | 0.66 (0.61, 0.73) < 0.0001 | 0.63 (0.56, 0.70) < 0.0001 | 0.54 (0.47, 0.62) < 0.0001 | 0.56 (0.48, 0.65) < 0.0001 | |
Yes | 2541 | 1 [Reference] | 0.74 (0.52, 1.04) 0.0853 | 0.71 (0.56, 0.91) 0.0073 | 0.61 (0.46, 0.81) 0.0006 | 0.64 (0.44, 0.94) 0.0241 | 0.44 (0.27, 0.71) 0.0009 | 0.78 (0.44, 1.36) 0.3772 |
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Li, Q.; Pan, X.; Li, X.; Huang, W. Association of Physical Activity Intensity with All-Cause Mortality in Cancer Survivors: A National Prospective Cohort Study. Cancers 2022, 14, 5760. https://doi.org/10.3390/cancers14235760
Li Q, Pan X, Li X, Huang W. Association of Physical Activity Intensity with All-Cause Mortality in Cancer Survivors: A National Prospective Cohort Study. Cancers. 2022; 14(23):5760. https://doi.org/10.3390/cancers14235760
Chicago/Turabian StyleLi, Qiguang, Xueqiang Pan, Xiao Li, and Wei Huang. 2022. "Association of Physical Activity Intensity with All-Cause Mortality in Cancer Survivors: A National Prospective Cohort Study" Cancers 14, no. 23: 5760. https://doi.org/10.3390/cancers14235760