Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients
Abstract
:Simple Summary
Abstract
1. Introduction
2. The Immunomodulatory Activity of the Intestinal Microbiome
3. The Role of Dietary Fiber and Short-Chain Fatty Acids
4. The Effectiveness of Cancer Immunotherapy Depends on the Microbiome
5. Gut Microbiota Species Associated with the Efficacy of Immunotherapy
6. Our Own Observations on the Relationship between the Gut Microbiome and the Effectiveness of Anti-PD-1 or Anti-PD-L1 Immunotherapy in NSCLC Patients
7. Probiotics and Prebiotics
8. Micronutrients, Gut Microbiome and Cancer
8.1. Vitamin A
8.2. B Vitamins
8.3. Vitamin C
8.4. Vitamin D
8.5. Vitamin E
8.6. Vitamin K
8.7. Iron
8.8. Zinc
8.9. Magnesium
Micronutrient | Influence on Microbiome | Reference |
---|---|---|
Vitamin A | Akkermansia ↑ | [83] |
Bifidobacterium ↑ | [83,85] | |
Proteobacteria to Actinobacteria ratio ↑ Proteobacteria to Firmicutes ratio ↑ | [84] | |
Bacteroidetes ↑ Proteobacteria ↑ Actinobacter ↑ Enterobacter ↑ | [85] | |
Vitamin B1 | Bacteroides ↑, Faecalibacterium ↑, Prevotella ↑ | [99] |
Vitamin B2 | Faecalibacterium ↑, Roseburia ↑, Enterobacteriaceae ↓ | [101,102] |
Alistipes shahii ↑ | [103] | |
Vitamin B3 | Bacteroidetes ↑ | [103] |
Vitamin B12 | Akkermansia ↑ | [107] |
Vitamin C | Collinsella ↑ | [103] |
Bacteroides ↑, Roseburia ↑, Faecalibacterium ↑, Akkermansia ↑, Bifidobacterium ↑ | [109] | |
Vitamin D | Lactobacillus rhamnosus ↑, Lactobacillus plantarum ↑ | [115] |
Clostridium difficile ↓ | [114,116] | |
Akkermansia ↑, Faecalibacterium ↑, Coprococcus ↑ | [117] | |
Enterobacteria ↑ | [118] | |
Bifidobacterium longum ↑ | [119,120] | |
Ruminococcus ↑, Mogibacterium ↑, Blautia ↑ | [121] | |
Alistipes ↑, Roseburia ↑, Parabacteroides ↑ | [122,123] | |
Pediococcus ↑, Clostridium ↑, Escherichia ↑, Shigella ↑ | [124] | |
Vitamin E | Firmicutes ↑ | [127,128] |
Bacteroidetes cluster ↓ | [127] | |
Akkermansia ↑, Lactobacillus ↑, Bifidobacterium ↑, Faecalibacterium ↑ | [102,130] | |
Vitamin K | Bifidobacterium ↑, Lactobacillales ↑ | [135] |
Iron | Bifidobacterium ↓, Escherichia coli ↑, Ruminococcaceae ↑, Lachnospiraceae ↑, Erysipelotrichaceae ↑ | [138] |
Enterobacteriaceae ↑ | [139] | |
Lactobacillus ↓ | [138,139] | |
Zinc | Escherichia coli ↓, Clostriudium ↓ | [142] |
Ruminococcus flavefaciens ↑, Prevotella ↑ | [143,144] | |
Lactobacillus ↓ | [144,145,146] | |
Magnesium | Bifidobacterium ↑, Adlercreutzia ↑, Lachnospiraceae ↑ | [152] |
Lactobacillus ↑, Muribaculaceae ↓ | [153] | |
Selenium | Lachnospiraceae ↑, Ruminococcaceae ↑, Christensenellaceae ↑, Lactobacillus ↑ | [155] |
8.10. Selenium
8.11. Omega-3
9. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Malignancy | Treatment | Bacteria Correlated with Positive Immunotherapy Response | Reference |
---|---|---|---|
Non-small-cell lung cancer | anti-PD-L1 | Akkermansia muciniphila, Alistipes, Enterococcus hirae | [49,50,71] |
Bifidobacterium bifidum | [50,72] | ||
Alistipes putredinis, Prevotella copri, Bifidobacterium longum | [71] | ||
Methanobrevibacter and Parabacteroides | [70] | ||
Bifidobacterium breve, Propionibacterium acnes, Prevotella copri, Rikenellaceae, Staphylococcus aureus, Streptococcus, Peptostreptococcus, Oscillospira, Faecalibacterium prausnitzi, Bacteroides plebeius, Enterococcus hirae, Enterobacteriaceae | [7,71,73,74] | ||
Melanoma | anti-PD-L1 | Bifidobacterium, Akkermansia muciniphila, Alistipes, Enterococcus hirae, Faecalibacterium prausnitzii, Bacteroides thetaiotamicron, Holdemania filiformis, Bacteroides caccae | [62] |
anti-PD-L1, anti-CTLA-4 | Ruthenibacterium lactatiformans, Eubacterium limosum, Fusobacterium ulcerans, Phascolarctobacterium succinatutens, Bacteroides uniformis, Bacteroides dorei, Paraprevotella xylaniphila, Parabacteroides distasonis, Parabacteroides johnsonii | [56,68] | |
Enterococcus faecium, Collinsella aerofaciens, Bifidobacterium adolescentis, Klebsiella pneumoniae, Veillonella parvula, Parabacteroides merdae, Lactobacillus spp., Bifidobacterium longum | [69] | ||
Bifidobacterium longum, Collinsella aerofaciens, Enterococcus faecium | [49,61] | ||
Sarcoma | anti-PD1 or anti-CTLA-4 | Bacteroides fragilis, Bacteroides thetaiotamicron, Burkholderia, Akkermansia muciniphila, Enterococcus hirae, Alistipes | [49,52] |
Colorectal cancer | anti-PD1 or anti-CTLA-4 | Ruthenibacterium lactatiformans, Eubacterium limosum, Fusobacterium ulcerans, Phascolarctobacterium succinatutens, Bacteroides uniformis, Bacteroides dorei, Paraprevotella xylaniphila, Parabacteroides johnsonii, Parabacteroides gordonii, Alistipes senegalensis | [68] |
Renal cell carcinoma | anti-PD-L1 | Akkermansia muciniphila, Lachnospiraceae, Erisypelotrichaceae lacteria, Enterococus faevium, Alistipes indistinctus, Bacteroidaceae, Bacteriodes xylanisolvens, Bacteroides nordii | [49] |
Carcinoma hepatocellulare | anti-PD-1 | Streptococcus thermophilus, Fusobacterium ulcerans, Candidatus Liberibacter, Lactobacillus mucosae, Ruminococcus obeum, unclassified Lachnospiracae, Ruminococcus bromii, Subdoligranulum, Bacteroides cellulosyticus, Lactobacillus gasseri, Anaerotruncus colihominis, Eubacterium hallii, Dorea formicigenerans, Lactobacillus vaginalis, Dalister invisus, Lactobacillus oris, Akkermansia muciniphila, Bifidobacterium dentium, Megasphera micronuciformis, Coproccus comes | [75] |
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Frąk, M.; Grenda, A.; Krawczyk, P.; Milanowski, J.; Kalinka, E. Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients. Cancers 2022, 14, 5577. https://doi.org/10.3390/cancers14225577
Frąk M, Grenda A, Krawczyk P, Milanowski J, Kalinka E. Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients. Cancers. 2022; 14(22):5577. https://doi.org/10.3390/cancers14225577
Chicago/Turabian StyleFrąk, Małgorzata, Anna Grenda, Paweł Krawczyk, Janusz Milanowski, and Ewa Kalinka. 2022. "Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients" Cancers 14, no. 22: 5577. https://doi.org/10.3390/cancers14225577
APA StyleFrąk, M., Grenda, A., Krawczyk, P., Milanowski, J., & Kalinka, E. (2022). Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients. Cancers, 14(22), 5577. https://doi.org/10.3390/cancers14225577