External Beam Accelerated Partial Breast Irradiation in Early Breast Cancer and the Risk for Radiogenic Pneumonitis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Trial Results (n = 170) (Mean ± SD) | Lung Dose Constraints (Study Protocol) | Symptomatic Patient (n = 1) | |
---|---|---|---|
Ipsilateral lung | |||
MLD [Gy] | 4.3 ± 1.4 | - | 6.1 * |
D30 [Gy] | 5.0 ± 1.9 | <15 | 7.0 * |
D2 [Gy] | 23.5 ± 7.3 | - | 32.5 * |
D1 [Gy] | 28.2 ± 7.2 | - | 35.0 |
V5 [%] | 30.1 ± 13.1 | - | 47.0 * |
V10 [%] | 10.5 ± 5.6 | - | 15.0 |
V20 [%] | 3.0 ± 2.0 | - | 7.0 * |
V30 [%] | 1.0 ± 1.0 | - | 3.0 * |
Contralateral lung | 0.6 ± 0.6 | 0.2 | |
MLD [Gy] | 1.7 ± 1.4 | - | 0.5 |
D5 [Gy] | 1.8 ± 1.6 | <5.7 | 0.6 |
D2 [Gy] | 2.1 ± 2.1 | - | 0.8 |
D1 [Gy] | 0.6 ± 2.9 | - | 0 |
V5 [%] | - | ||
Total lung | |||
MLD [Gy] | 2.5 ± 0.8 | - | 3.6 * |
D2 [Gy] | 18.2 ± 6.5 | - | 30.5 * |
D1 [Gy] | 25.0 ± 7.5 | - | 33.9 * |
V5 [%] | 15.4 ± 7.0 | - | 27.0 * |
V10 [%] | 5.3 ± 2.8 | - | 9.0 * |
V20 [%] | 1.6 ± 1.1 | - | 4.0 * |
V30 [%] | 0.5 ± 0.6 | - | 2.0 * |
Reference | Data Source | Sample Size | Radiotherapy Scenario | Lung dose Parameters |
Current work | Prospective, clinical trial | 170 | External beam, 3D-CRT APBI (TD: 38 Gy, 10 fx) | V20: 3% MLD: 11% |
Recht et al. [16] | Prospective, clinical trial | 198 | External beam, 3D-CRT APBI (photons, electrons, protons, TD: 32-36 Gy, 8–9 fx) | MLD: 1.4–4% |
Stelczer et al. [15] | In silico study | 40 | External beam, 3D-CRT APBI (TD: 36.9 Gy, 9 fx) | MLD: 6% |
40 | External beam, IMRT APBI (TD: 36.9 Gy, 9 fx) | MLD: 7–10% | ||
Herein et al. [14] | In silico study | 32 | Multicatheter, interstitial HDR APBI (4× 6.25 Gy) | MLD: 5% |
32 | Stereotactic, external beam APBI (4× 6.25 Gy) | MLD: 5% | ||
Vasiljevic et al. [19] | Prospective, clinical trial | 100 | external beam WBI/chest wall irradiation (TD: 50–60 Gy, 25–30 fx) | V20: 8–13% |
Jensen et al. [20] | In silico study | 22 | Free breathing, VMAT WBI (TD: 50 Gy, 25 fx) | V20: 13% MLD: 12 % |
3D-CRT, DIBH WBI (TD: 50 Gy, 25 fx) | V20: 9% MLD: 15% | |||
Thomsen et al. [21] | Prospective, clinical trial | 917 | 3D-CRT WBI (TD: 40 Gy, 15fx) | V17: 14–17% |
937 | 3D-CRT WBI (TD: 50 Gy, 25fx) | V20: 14–17% | ||
Oechsner et al. [22] | In silico study | 31 | Free breathing, 3D-CRT WBI (TD: 50 Gy, 25 fx) | V20: 19% MLD: 20% |
DIBH, 3D-CRT WBI (TD: 50 Gy, 25 fx) | V20: 14% MLD: 16% | |||
Gaál et al. [23] | Prospective, clinical trial | 54 | Free breathing, 3D-CRT WBI (TD: 50 Gy, 25 fx) | V20: 12% MLD: 14% |
DIBH, 3D-CRT WBI (TD: 50 Gy, 25 fx) | V20: 11% MLD: 13% | |||
Pandeli et al. [24] | In silico study | 20 | Free breathing, 3D-CRT WBI (TD: 40 Gy, 15 fx) | V20: 8% MLD: 11% |
DIBH, 3D-CRT WBI (TD: 40 Gy, 15 fx) | V20: 8% MLD: 11% |
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Ott, O.J.; Stillkrieg, W.; Lambrecht, U.; Sauer, T.-O.; Schweizer, C.; Lamrani, A.; Strnad, V.; Hack, C.C.; Beckmann, M.W.; Uder, M.; et al. External Beam Accelerated Partial Breast Irradiation in Early Breast Cancer and the Risk for Radiogenic Pneumonitis. Cancers 2022, 14, 3520. https://doi.org/10.3390/cancers14143520
Ott OJ, Stillkrieg W, Lambrecht U, Sauer T-O, Schweizer C, Lamrani A, Strnad V, Hack CC, Beckmann MW, Uder M, et al. External Beam Accelerated Partial Breast Irradiation in Early Breast Cancer and the Risk for Radiogenic Pneumonitis. Cancers. 2022; 14(14):3520. https://doi.org/10.3390/cancers14143520
Chicago/Turabian StyleOtt, Oliver J., Wilhelm Stillkrieg, Ulrike Lambrecht, Tim-Oliver Sauer, Claudia Schweizer, Allison Lamrani, Vratislav Strnad, Carolin C. Hack, Matthias W. Beckmann, Michael Uder, and et al. 2022. "External Beam Accelerated Partial Breast Irradiation in Early Breast Cancer and the Risk for Radiogenic Pneumonitis" Cancers 14, no. 14: 3520. https://doi.org/10.3390/cancers14143520