MicroRNAs, Tristetraprolin Family Members and HuR: A Complex Interplay Controlling Cancer-Related Processes
Abstract
:Simple Summary
Abstract
1. Introduction
2. MiRNAs: From Biogenesis to a Complex Regulatory Network
3. AUBPs Interfering with miRNAs-Dependent Regulation
3.1. HuR
3.1.1. Competitive Antagonism between HuR and miRNAs
3.1.2. Other Antagonisms between HuR and miRNAs
3.1.3. Cooperation between HuR and miRNAs
3.2. TTP Family Members (TTP, TIS11, GOS24, NUP475)
4. MiRNAs-Regulating HuR and TTP Family Members
4.1. HuR
4.2. TTP Family Members
4.2.1. Tristetraprolin (ZFP36)
4.2.2. Butyrate Response Factor 1 (ZFP36L1)
4.2.3. Butyrate Response Factor 2 (ZFP36L2)
miRNA | Targets (AUBPs) | Models Used | Expression/Activity in Patients | Reference |
---|---|---|---|---|
Gastric cancer | ||||
miR-145 | ELAVL1 | SK-OV-3, A2780 and OVCAR-3 | Down | [161] |
miR-519 | n.a | Down | [162] | |
miR-582-3p | HGC27, BGC823 cells | Down | [163] | |
Ovarian cancer | ||||
miR-139-3p | ELAVL1 | SK-OV-3, A2780 and OVCAR-3 | Down | [166] |
miR-519 | Hela, A21780 and HOSE-B cells | Down | [167] | |
Papillary thyroid carcinoma | ||||
miR-31 | ELAVL1 | Ovarian carcinoma cells | Down | [169] |
Non-small cell lung carcinoma | ||||
miR-139-3p | ELAVL1 | Normal bronchial epithelial cells (BEAS-2B) and NSCLC cells (H1299, H1975, HCC827, H1650 A549) | Down | [172] |
miR-146a-5p | A549 cells | Down | [173] | |
miR-31 | n.a | Down | [174] | |
miR-519 | Hela, A21780 and HOSE-B cells | Down | [167] | |
miR-373 | ZFP36L2 | A549 cells | Down | [214] |
Lung adenocarcinoma | ||||
Let-7b-3p | ZFP36L2 | H1299, A549 cells | Down | [215] |
Hepatocellular carcinoma | ||||
miR-16 | ELAVL1 | Hep3B, WRL68 | Down | [165] |
miR-9-5p | ZFP36 | HuH7, Hep3B | Down | [208] |
Colorectal cancer | ||||
miR-22 | ELAVL1 | NCM460, SW480, HT29, HCT15, HCT116, SW620, Caco2, LOVO | Down | [175] |
miR-324-5p | SW620, SW480, NCM-460 cells | Down | [176] | |
miR-519 | S1, S1M1 80 (mitoxantrone-resistant), Caco-2, HT-29, SW620 | Down | [168,177] | |
miR-155-5p | HT-29 | Up | [178,216] | |
miR-34b-5p | NCM460, SW620, HT-29, HCT116, LoVo, RKO | Down | [60] | |
miR-3121-3p | DLD-1, HCT116, HT29, SW480 | Down | [179]. | |
Prostate cancer | ||||
miR-133b | ELAVL1 | PC3, DU-145 cell lines | Down | [189,217,218] |
miR-34a | PC3 | Down | [191,219] | |
Cervical cancer | ||||
miR-324-5p | ELAVL1 | 33A, ME-180, Hela and Caski | Down | [168,180] |
miR-519 | Hela cells | Down | [168,180] | |
Pancreatic cancer | ||||
miR-29a | ZFP36 | Panc-1, HPDE6c7, BXPC-3 | Up | [204] |
miR-375 | ZFP36L2 | Pancreatic ductal adenocarcinoma PANC-1 and SW1990 | Down | [213] |
Glioblastoma | ||||
miR-3127-5p | ELAVL1 | Down | [183] | |
miR-146b-5p | Glioma stem cells | Down | [184] | |
miR-129-5p | ZFP36L1 | LN229, A172, U87, T98G, U251, H4, LN118 and normal astrocytes | Down | [211] |
Breast cancer | ||||
miR-16 | ELAVL1 | MDA-MB-231 | Down | [185] |
miR-125a | MCF-7 | Down | [186,220] | |
miR-29a | ELAVL1 (indirectly) | MDA-MB-231, MCF-7, MCF12A, MCF10A cells | Up | [188] |
miR-519 | ELAVL1 | MCF-7 cells | Down | [187] |
miR-29a | ZFP36 | MDA-MB-231 and MCF-7, MCF12A and MCF10A (normal-like breast cell line), and HEK293 kidney cells | Up | [188,203] |
miR-182 | ZFP36 | MDA-MB-231, SUM-159, MCF-7, SK-BR-3, MDA-MB-157 | Up | [206] |
miR-200c | ZFP36 | 4TO7 cells | Up | [209,221] |
Nasopharyngeal carcinoma | ||||
miR-514-5p | ELAVL1 | CNE1, CNE2, C666–1 and HNE1 cells | Down | [192] |
Oropharyngeal squamous cell carcinoma | ||||
miR-133a-3p | ELAVL1 | UMSCC47 and UMSCC11A cells | Down | [193] |
Laryngeal squamous cell carcinoma | ||||
miR-519a | ELAVL1 | laryngeal squamous cell carcinoma human epithelial type 2 cells | Down | [194] |
Hematologic malignancies | ||||
miR-519 | ELAVL1 | HL-60 cells (AML) | Up | [196] |
miR-25 | ELAVL1 (indirectly) | U937 (AML) | Down | [198,222] |
miR-199a-3p | ELAVL1 | Bone marrow cells | n.a. | [197] |
miR-25 | ELAVL1 (indirect) | Bone marrow cells | Down | [197,222] |
miR-146b | ELAVL1 | T-large granular lymphocyte leukemia (T-LGLL), | Down | [200] |
miR-128a | ZFP36 | AML cells (OCI-AML3 and APL/AML) | Up | [207] |
miR-181b | ZFP36L1 (not validated) | CLL cells | Down | [212] |
miR-9 | ELAVL1 | Hodgkin lymphoma L428 cells | Up | [123,223] |
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
References
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Sobolewski, C.; Dubuquoy, L.; Legrand, N. MicroRNAs, Tristetraprolin Family Members and HuR: A Complex Interplay Controlling Cancer-Related Processes. Cancers 2022, 14, 3516. https://doi.org/10.3390/cancers14143516
Sobolewski C, Dubuquoy L, Legrand N. MicroRNAs, Tristetraprolin Family Members and HuR: A Complex Interplay Controlling Cancer-Related Processes. Cancers. 2022; 14(14):3516. https://doi.org/10.3390/cancers14143516
Chicago/Turabian StyleSobolewski, Cyril, Laurent Dubuquoy, and Noémie Legrand. 2022. "MicroRNAs, Tristetraprolin Family Members and HuR: A Complex Interplay Controlling Cancer-Related Processes" Cancers 14, no. 14: 3516. https://doi.org/10.3390/cancers14143516