Effectiveness of Outpatient Pulmonary Rehabilitation in Patients with Surgically Resected Lung Cancer: A Retrospective Real-World Analysis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Methods
2.1. Study Design
2.2. Ethics Approval and Informed Consent
2.3. Rehabilitation Procedures
2.4. Outcome Variables
2.5. Statistical Analysis
3. Results
3.1. Study Population and Adherence
3.2. Changes in Outcome Variables
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patient Characteristic † | Mean (SD), Number (%) | Available Data/Total Number |
---|---|---|
Age | 52/52 | |
Age (years) | 56.4 (9.2) | |
Range (years) | 37–76 | |
Sex | 52/52 | |
female | 30 (58%) | |
male | 22 (42%) | |
Body weight | 51/52 | |
BMI (kg/m2) | 27.3 (5.3) | |
Current smoker | 11 (21%) | 52/52 |
Tumor Stage ‡ | 49/52 | |
Stage I | 30 (61.2%) | |
Stage II | 5 (10.2%) | |
Stage III | 14 (28.6%) | |
Stage IV | 0 (0%) | |
Range | IA—IIIA | |
Histology | 52/52 | |
NSCLC | 44 (84.6%) | |
Adenocarcinoma | 33 (63.5%) | |
Squamous-cell carcinoma | 5 (9.6%) | |
Adeno-squamous carcinoma | 1 (1.9%) | |
NSCLC-NOS | 5 (9.6%) | |
Neuro-endocrine tumor | 8 (15.4%) | |
SCLC | 1 (1.9%) | |
LC-NEC III | 2 (3.8%) | |
Carcinoid tumor | 5 (9.6%) | |
Prior oncologic therapy | 44/52 52/52 | |
Chemotherapy | 24 (54.5%) | |
Surgery | 52 (100%) |
Assessment | Number of Patients | Admission Mean (SD) | Discharge Mean (SD) | Difference | MCID | p-Value |
---|---|---|---|---|---|---|
6-MWT (m) | 44 | 472.8 (94.3) | 522.9 (91.5) | +50.2 (10.6%) | 61% | <0.001 |
Wmax (W) | 43 | 100.9 (31.6) | 115.9 (32.5) | +14.6 (14.0%) | 66% | <0.001 |
CWR70% (min) | 40 | 9.6 (7.4) | 14.0 (8.6) | +4.4 (45.8%) | 65% | <0.001 |
CAT (score) | 24 | 14.6 (7.7) | 11.5 (7.5) | −3.1 (21.2%) | 71% | 0.001 |
Assessment | Number of Patients | Admission Mean (SD) | Discharge Mean (SD) | Difference (%) | p-Value |
---|---|---|---|---|---|
PiMax (mbar) | 43 | 82.7 (34.9) | 100.2 (34.0) | +17.5 (21.2%) | <0.001 |
UE (kg) | 33 | 22.0 (8.5) | 28.6 (9.2) | +6.7 (30.5%) | <0.001 |
LE (kg) | 32 | 107.7 (32.2) | 131.3 (33.1) | +23.6 (22.3%) | <0.001 |
FEV1 (L) | 46 | 2.1 (0.6) | 2.0 (0.5) | −0.1 (4.8%) | 0.090 |
FEV1%FVC | 46 | 71.6 (9.0) | 70.8 (8.8) | −0.8 (1.1%) | 0.394 |
RV (L) | 44 | 2.6 (0.8) | 2.5 (0.7) | −0.1 (3.8%) | 0.471 |
BMI (kg/m2) | 51 | 27.3 (5.3) | 27.4 (5.3) | +0.1 (0.3%) | 0.631 |
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Illini, O.; Valipour, A.; Gattinger, D.; Petrovic, M.; Fabikan, H.; Hochmair, M.J.; Zwick, R.H. Effectiveness of Outpatient Pulmonary Rehabilitation in Patients with Surgically Resected Lung Cancer: A Retrospective Real-World Analysis. Cancers 2022, 14, 3479. https://doi.org/10.3390/cancers14143479
Illini O, Valipour A, Gattinger D, Petrovic M, Fabikan H, Hochmair MJ, Zwick RH. Effectiveness of Outpatient Pulmonary Rehabilitation in Patients with Surgically Resected Lung Cancer: A Retrospective Real-World Analysis. Cancers. 2022; 14(14):3479. https://doi.org/10.3390/cancers14143479
Chicago/Turabian StyleIllini, Oliver, Arschang Valipour, Dietlinde Gattinger, Milos Petrovic, Hannah Fabikan, Maximilian Johannes Hochmair, and Ralf Harun Zwick. 2022. "Effectiveness of Outpatient Pulmonary Rehabilitation in Patients with Surgically Resected Lung Cancer: A Retrospective Real-World Analysis" Cancers 14, no. 14: 3479. https://doi.org/10.3390/cancers14143479